Dmel\P{GawB}ptc^559.1 Insertion

General Information
Symbol	Dmel\P{GawB}ptc^559.1	Species	D. melanogaster
Name		FlyBase ID	FBti0002124
Feature type	transposable_element_insertion_site	Created / Updated	1997-03-21/2003-10-22
Description
Inserted element	P{GawB}	Localized function
Affected gene(s)	ptc	Expression data	GAL4 reporter/driver
Causes allele(s)	ptc^559.1	Viability / fertility
LINE ID		Stock availability
Genomic Location
Chromosomal location	2R ( 44D5-44E1 )	Sequence location
Detailed Mapping Data
Chromosome (arm)
Sequence Location
Orientation
Cytological location (computed by FlyBase)	44D5-44E1 ( near gene of known cytology )
Cytological location (reported)
Chromosome in situ
Sequence Data
Flanking sequence
Inserted Element
Construct	P{GawB}
Location-dependent role
Size	11.279Kb
Associated alleles	w^+mW.hs Scer\GAL4^wB
Molecular map
Transposon class
Element type
Affected Gene(s)
Insertion within gene
Insertion may affect gene	ptc (Wilder and Perrimon, 1995, Wodarz et al., 1995)
Orientation (relative to gene)	Gene Orientation References
Alleles and Phenotypes
Causes alleles	ptc^559.1 (Shyamala and Bhat, 2002, Thomas and Ingham, 2003)

Lethality References
Sterility References
Phenotype Manifest In
	ocellar triangle (Thomas and Ingham, 2003) fronto-orbital plate (Thomas and Ingham, 2003) frons (Thomas and Ingham, 2003) eye (Thomas and Ingham, 2003) head capsule & cuticle \| ectopic (Thomas and Ingham, 2003) head bristle (Thomas and Ingham, 2003) head bristle \| ectopic (Thomas and Ingham, 2003) ocellus (Thomas and Ingham, 2003) head capsule (Shyamala and Bhat, 2002) antenna (Thomas and Ingham, 2003)
Detailed Description
Statement Reference The addition of smo¹ to ptc^H84/ptc^559.1 animals produces an enhancement of the head capsule defect phenotype. 35% of animals exhibit the phenotype, compared to 4%. The addition of babo^{Q302D.Scer\UAS} (driven by Scer\GAL4^ptc-559.1) suppresses the head phenotype seen in ptc^559.1, Df(2R)Np3. None of these animals exhibit head capsule defects. (Shyamala and Bhat, 2002) No homozygotes show head capsule defects. 3% of ptc^hdl/ptc^559.1 transheterozygotes show head capsule defects. 4% of ptc^H84/ptc^559.1 transheterozygotes show head capsule defects. 67% of Df(2R)Np3/ptc^559.1 transheterozygotes show head capsule defects. (Shyamala and Bhat, 2002) Most ptc alleles in trans to ptc^559.1 do not cause head defects (ptc¹⁴ and ptc^G12) or have relatively mild head defects. The most severe (ptc³⁷ and ptc¹⁷) have mildly reduced eyes, slightly enlarged head vertex (ocellar triangle, fronto-orbital plate and frons) and low incidences of head cuticle outgrowths and ectopic or misplaced head bristles. The next most severely affected (ptc⁴⁷, ptc¹⁶) are as above, apart from having a normal sized head vertex. Finally the most mildly affected have wild-type heads, apart from occasional missing or misplaced head bristles (ptc^H84, ptc^tuf-1, ptc³⁴, ptc¹⁵ and ptc^S2). ptc¹³ falls into this category, but also has enlarged ocelli (not seen with other alleles). ptc⁹ also falls into this category, but along with ptc⁴⁷ and ptc¹⁷ occasionally lacks one or both antennae. (Thomas and Ingham, 2003)
Expression Data
Reporter Expression
Stage Tissue/Position Reference adult stage thoracic ganglion \| posterior (Monastirioti, 2003) adult stage mushroom body (Monastirioti, 2003) larval stage \| third instar dorsal mesothoracic disc \| restricted (Hinz et al., 1994) embryonic stage \| late embryonic brain \| segmentally repeated pattern (Page, 2002) embryonic stage \| late foregut visceral mesoderm (Page, 2002) larval stage \| third instar dorsal mesothoracic disc \| A/P boundary (Speicher et al., 1994) embryonic stage (Speicher et al., 1994) larval stage \| third instar dorsal mesothoracic disc \| restricted (Feger et al., 1995) larval stage \| third instar dorsal mesothoracic disc \| restricted (Sun and Artavanis-Tsakonas, 1997)
Additional Information
Statement Reference In wing disc, expressed in a stripe of cells along the anterior-posterior border. (Sun and Artavanis-Tsakonas, 1997) In embryonic brain, higher levels in region surrounding foregut (a region of hh expression). Expressed in embryonic brain in a segmental pattern complementary to that of hh. (Page, 2002) Adult expression is observed in the mushroom body and in the posterior tip of the thoracic ganglion. (Monastirioti, 2003)

Assay mode
Marker for	thoracic ganglion \| posterior mushroom body (Monastirioti, 2003) thoracic ganglion \| posterior (Monastirioti, 2003) mushroom body (Monastirioti, 2003)
Reflects expression of	ptc (Hinz et al., 1994, Monastirioti, 2003) h (Speicher et al., 1994)
External Images
FlyView (LinkOut)
Data on Genetic Line
Line ID
Origin as a multiple insertion line
Progenitor(s) within the Genome

Related Aberration or Balancer
Aberration
Balancer
Stocks ( 2 )
Bloomington	2017 w^*; P{GawB}ptc^559.1
Kyoto	106629 w^*; P{GawB}ptc^559.1
Linkouts
Synonyms & Secondary IDs
Reported As
Symbol Synonym	559.1 (Inaki et al., 2002, Kojima et al., 2000, Yasunaga et al., 2006) (ptc)-GAL4 (Cho et al., 2001) (ptc)Gal4 (Gieseler et al., 2001) Gal4^559.1 (Keisman et al., 2001) GAL4-ptc (de Celis et al., 1995) P{GawB}559.1 (Reichhart et al., 2002, Shiga et al., 2002, FlyBase, 1992-, With et al., 2003) P{GawB}ptc-559.1 (FlyBase, 1992-) P{GawB}ptc^559.1 (Takeyama et al., 2002, FlyBase, 1992-, Meyer et al., 2006) P{ptc-GAL4} (Casanueva and Ferguson, 2004) P{w+; Ptc-GAL4} (Walters et al., 2005) P{w+;Ptc-GAL4} (Walters et al., 2006) P{w+mW.hs=GawB}559.1 (Lawrence et al., 2002) P{w^+mW.hs=GawB}ptc-559.1 (FlyBase, 1992-) patched^Gal4 (Neubueser et al., 2005, Kerber et al., 2001) patched-gal4 (Soustelle et al., 2004, FlyBase, 1992-) patched-GAL4 (Narbonne et al., 2004, Shivdasani and Ingham, 2003, Delon et al., 2003, Schulz et al., 2001, Matsuno et al., 2002, Yeh et al., 2001, Dietrich et al., 2001, Kramer et al., 2001, Kramer et al., 2001, True et al., 2005, Kamimura et al., 2004) patched-Gal4 (Rosin et al., 2004, Speck et al., 2003, Goto et al., 2001, Zeidler et al., 2000, Munro and Freeman, 2000, Abdelilah-Seyfried et al., 2000, Ryoo and Mann, 1999, Herranz et al., 2006, Childress et al., 2006) patched Gal4 (Venkei et al., 2006) patched Gal-4 (Deshpande and Schedl, 2005) patch-G4 (Baena-Lopez and Garcia-Bellido, 2003) patch-Gal4 (Odden et al., 2002) prcGal4 (G559.1) (Murakami et al., 2007) ptc::Gal4 (Huh et al., 2004, Glittenberg et al., 2006, Hulsmeier et al., 2007) ptc:Gal4 (Ryoo et al., 1999) ptc.Gal4 (Casal et al., 2002, Lawrence et al., 2002, Marquez et al., 2001, Lawrence et al., 2004, Thompson and Cohen, 2006, Takaesu et al., 2005, Casal et al., 2006) ptc^559.1-Gal4 (Nagel et al., 2002, Nagel et al., 2001, de NavascuÃ©s and Modolell, 2007) ptc^559.1-GAL4 (Apidianakis et al., 1999) ptc^Gal4 (Hipfner et al., 2004, Baron et al., 2000) ptc^GAL4 (Hipfner and Cohen, 2003, Emerald et al., 2003) ptcG4 (Sun and Artavanis-Tsakonas, 1997, Baena-Lopez and Garcia-Bellido, 2006) ptc-GAL (Campbell, 2002, Sugiyama et al., 2007) ptc-GAL4 (Aboobaker et al., 2005, Ishikawa et al., 2005, Kon, 2005, Sapir, 2005, Zhang, 2004, Bhat, 2005, Takeo et al., 2005, Bajpai et al., 2004, Hori et al., 2004, Donaldson et al., 2004, Monastirioti, 2003, Boettner et al., 2003, Pallavi and Shashidhara, 2003, Suzanne et al., 2003, Bastock et al., 2003, Culi and Mann, 2003, Negeri et al., 2002, Schulz et al., 2002, Parker et al., 2002, Lee and Adler, 2002, Tazuke et al., 2002, Price and Kalderon, 2002, Micchelli et al., 2002, Seong et al., 2002, Yoshida et al., 2001, Fujise et al., 2001, Martin et al., 2001, Simmonds et al., 2001, Axelrod, 2001, Kataoka et al., 2001, Lee et al., 2001, Takashima and Murakami, 2001, Liu et al., 2000, Furriols and Bray, 2000, Wang et al., 2000, Yeh et al., 2000, Rulifson et al., 2000, Tsuji et al., 2000, Conley et al., 2000, Brown and Castelli-Gair Hombria, 2000, Aza-Blanc et al., 2000, Strigini and Cohen, 2000, Cooper et al., 2000, Mohler et al., 2000, Vaudin et al., 1999, Wessells et al., 1999, Kanuka et al., 1999, Maier et al., 1999, Usui et al., 1999, Tsuda et al., 1999, Ricos et al., 1999, Rincon-Limas et al., 1999, Varadarajan and VijayRaghavan, 1999, Simmonds et al., 1998, Kojima et al., 2000, Keisman et al., 2001, Kaltschmidt et al., 2002, Sasamura et al., 2003, Yasunaga et al., 2006, Ren et al., 2006, Zhou et al., 2006, Strutt et al., 2006, Mohit et al., 2006, Tsuda et al., 2006, Nairz et al., 2006, Otsuki et al., 2004, Hsu et al., 2007, Ogden et al., 2006, Fouix et al., 2003, Legent et al., 2006, With et al., 2003, Deshpande et al., 2007, He et al., 2005, He et al., 2005) ptc-Gal4 (Ronshaugen et al., 2005, Okajima et al., 2005, Okajima, 2005, Sakata, 2004, Roper et al., 2005, Krupp et al., 2005, Major and Irvine, 2005, Pitsouli and Delidakis, 2005, Hatini et al., 2005, Macias et al., 2004, Buescher et al., 2004, Adler et al., 2004, Gaziova et al., 2004, Pierce et al., 2004, Torroja et al., 2004, Stark et al., 2003, Yan et al., 2004, Liang et al., 2003, Lin et al., 2003, Dai et al., 2003, Brennecke et al., 2003, Okajima and Irvine, 2002, Crozatier et al., 2002, Nakagoshi et al., 2002, Besse et al., 2002, Cavodeassi et al., 2002, Glise et al., 2002, Tree et al., 2002, Salles et al., 2002, Ohshiro et al., 2002, Britton et al., 2002, Herranz and Morata, 2001, Kumar et al., 2001, Buckles et al., 2001, Baeg et al., 2001, Piepenburg et al., 2000, Ju et al., 2000, Klein et al., 2000, Casares and Mann, 2000, Matakatsu et al., 1999, Sato et al., 1999, Schweisguth, 1999, Payre et al., 1999, Vervoort et al., 1999, Jennings et al., 1999, Abu-Shaar et al., 1999, Alves et al., 1998, Rorth, 1998, Shiga et al., 2002, Inaki et al., 2002, Stevens and Mann, 2007, McEwen and Peifer, 2005, Maier et al., 2006, Speder et al., 2006, Crickmore and Mann, 2006, Crickmore and Mann, 2006, Herranz et al., 2006, de Navas et al., 2006, Lei et al., 2003, Chung et al., 2007, Sasaki et al., 2007, Crickmore and Mann, 2007, Okamura et al., 2007) ptcGal4 (Brennecke, 2005, Emerald and Cohen, 2004, Desbordes and Sanson, 2003, MacKay et al., 2003, Gallet et al., 2003, Llimargas and Lawrence, 2001, Weihe et al., 2001, Gallet et al., 2000, Von Ohlen and Hooper, 1999, Koelzer and Klein, 2006, Cela and Llimargas, 2006, Zeitler et al., 2004, Delanoue et al., 2002, Garg et al., 2007, Swan and Schupbach, 2007, Hayward et al., 2005) ptc-gal4 (Sakata et al., 2004, Schulz et al., 2004, Matakatsu and Blair, 2004, Milan et al., 2004, Vegh and Basler, 2003, Nakamura et al., 2002, Milan et al., 2001, Milan et al., 2001, Svendsen et al., 2000, Milan and Cohen, 1999, Volohonsky et al., 2007) Ptc-gal4 (Wilkin et al., 2004) Ptc-Gal4 (de Celis Ibeas and Bray, 2003, Chanut-Delalande et al., 2006, Rives et al., 2006) ptcGAL4 (Hao et al., 2003, Klein, 2003, Kaltschmidt et al., 2002, Hannus et al., 2002, Cohen et al., 2002, Rauskolb, 2001, Feiguin et al., 2001, Brentrup et al., 2000, Ainsworth et al., 2000, Wang and Holmgren, 2000, Lawrence et al., 2000, Brennan et al., 1999, Wang and Holmgren, 1999, Charroux et al., 1999, Price and Kalderon, 1999, Hepker et al., 1999, Couso et al., 1995, Ward et al., 2006, Brodu and Casanova, 2006, Zeitler et al., 2004) Ptc-GAL4 (Tolwinski et al., 2003, Hatini and DiNardo, 2001, Hatini et al., 2000, Gritzan et al., 1999, Diaz-Benjumea and Cohen, 1995) ptc Gal4 (Johnson et al., 2002) PtcGal4 (Raymond et al., 2001) ptcgal4 (Greco et al., 2001, Gallet et al., 2006) ptc GAL4 (Franch-Marro et al., 2006) ptc-Gal4^559.1 (Bachmann et al., 2004) ptcGal4^559.1 (Hooper, 2003) ptch-G4 (Baena-Lopez and Garcia-Bellido, 2003)
Secondary FlyBase IDs
	FBti0001272 FBti0027410
References ( 331 )

Generate a list of	All references relating to this insertion ( 331 )

List References by type	Research paper ( 325 ) Supplementary material ( 5 ) FlyBase analysis ( 1 )
Recent research papers ( 44 )
	Chung et al., 2007, Genetics 176(2): 891--903 The balance between the novel protein target of wingless and the Drosophila Rho-associated kinase pathway regulates planar cell polarity in the Drosophila wing. [FBrf0202398] Crickmore and Mann, 2007, Development 134(2): 327--334 Hox control of morphogen mobility and organ development through regulation of glypican expression. [FBrf0194329] de NavascuÃ©s and Modolell, 2007, Development 134(9): 1779--1788 tailup, a LIM-HD gene, and Iro-C cooperate in Drosophila dorsal mesothorax specification. [FBrf0201638] Deshpande et al., 2007, Genetics 176(2): 905--912 toutvelu, a regulator of heparan sulfate proteoglycan biosynthesis, controls guidance cues for germ-cell migration. [FBrf0201363] Garg et al., 2007, Genetics 175(2): 659--669 Antagonizing scalloped with a novel vestigial construct reveals an important role for scalloped in Drosophila melanogaster leg, eye and optic lobe development. [FBrf0193374] Hsu et al., 2007, Nature 445(7129): 785--788 Drosophila TCTP is essential for growth and proliferation through regulation of dRheb GTPase. [FBrf0192022] Hulsmeier et al., 2007, Development 134(4): 713--722 Distinct functions of α-Spectrin and β-Spectrin during axonal pathfinding. [FBrf0194635] Murakami et al., 2007, Development Suppl.: Focal adhesion kinase controls morphogenesis of the Drosophila optic stalk. [FBrf0193558] Okamura et al., 2007, Cell 130(1): 89--100 The mirtron pathway generates microRNA-class regulatory RNAs in Drosophila. [FBrf0200988] Sasaki et al., 2007, Genes to Cells 12(1): 89--103 Polarized exocytosis and transcytosis of Notch during its apical localization in Drosophila epithelial cells. [FBrf0192755] Stevens and Mann, 2007, Genetics 175(4): 1625--1636 A balance between two nuclear localization sequences and a nuclear export sequence governs extradenticle subcellular localization. [FBrf0200370] Sugiyama et al., 2007, Genetics 176(2): 927--936 Involvement of the mitochondrial protein translocator component Tim50 in growth, cell proliferation and the modulation of respiration in Drosophila. [FBrf0200675] Swan and Schupbach, 2007, Development 134(5): 891--899 The Cdc20 (Fzy)/Cdh1-related protein, Cort, cooperates with Fzy in cyclin destruction and anaphase progression in meiosis I and II in Drosophila. [FBrf0194687] Volohonsky et al., 2007, Development 134(2): 347--356 Muscle-dependent maturation of tendon cells is induced by post-transcriptional regulation of stripeA. [FBrf0192282] Baena-Lopez and Garcia-Bellido, 2006, Proc. Natl. Acad. Sci. USA 103(37): 13734--13739 Control of growth and positional information by the graded vestigial expression pattern in the wing of Drosophila melanogaster. [FBrf0193315] Brodu and Casanova, 2006, Genes Dev. 20(13): 1817--1828 The RhoGAP crossveinless-c links trachealess and EGFR signaling to cell shape remodeling in Drosophila tracheal invagination. [FBrf0195282] Casal et al., 2006, Development 133(22): 4561--4572 Two separate molecular systems, Dachsous/Fat and Starry night/Frizzled, act independently to confer planar cell polarity. [FBrf0194266] Cela and Llimargas, 2006, Development 133(16): 3115--3125 Egfr is essential for maintaining epithelial integrity during tracheal remodelling in Drosophila. [FBrf0192922] Chanut-Delalande et al., 2006, PLoS Biol. 4(9): Shavenbaby couples patterning to epidermal cell shape control. [FBrf0191902] Crickmore and Mann, 2006, Science 313(5783): 63--68 Hox control of organ size by regulation of morphogen production and mobility. [FBrf0195181] de Navas et al., 2006, Development 133(22): 4495--4506 The Ultrabithorax Hox gene of Drosophila controls haltere size by regulating the Dpp pathway. [FBrf0194425] Franch-Marro et al., 2006, Development 133(5): 785--790 Association of tracheal placodes with leg primordia in Drosophila and implications for the origin of insect tracheal systems. [FBrf0190289] Gallet et al., 2006, Development 133(3): 407--418 Cholesterol modification is necessary for controlled planar long-range activity of Hedgehog in Drosophila epithelia. [FBrf0190290] Glittenberg et al., 2006, EMBO J. 25(20): 4697--4706 Role of conserved intracellular motifs in Serrate signalling, cis-inhibition and endocytosis. [FBrf0192221] Herranz et al., 2006, Development 133(14): 2617--2625 calderon encodes an organic cation transporter of the major facilitator superfamily required for cell growth and proliferation of Drosophila tissues. [FBrf0194487] Koelzer and Klein, 2006, Dev. Biol. 289(1): 77--90 Regulation of expression of Vg and establishment of the dorsoventral compartment boundary in the wing imaginal disc by Suppressor of Hairless. [FBrf0190133] Legent et al., 2006, Genes to Cells 11(8): 907--918 Cell cycle genes regulate vestigial and scalloped to ensure normal proliferation in the wing disc of Drosophila melanogaster. [FBrf0193006] Maier et al., 2006, Gene Expression Patterns 6(8): 849--856 Drosophila protein kinase D is broadly expressed and a fraction localizes to the Golgi compartment. [FBrf0192171] Meyer et al., 2006, PLoS Gen. 2(8): Overlapping functions of argonaute proteins in patterning and morphogenesis of Drosophila embryos. [FBrf0194224] Mohit et al., 2006, Dev. Biol. 291(2): 356--367 Modulation of AP and DV signaling pathways by the homeotic gene Ultrabithorax during haltere development in Drosophila. [FBrf0190145] Nairz et al., 2006, Dev. Biol. 291(2): 314--324 Overgrowth caused by misexpression of a microRNA with dispensable wild-type function. [FBrf0190148] Neuburger et al., 2006, Genetics 173(3): 1377--1387 A genetic suppressor of two dominant temperature-sensitive lethal proteasome mutants of Drosophila melanogaster is itself a mutated proteasome subunit gene. [FBrf0194466] Ogden et al., 2006, J. Biol. Chem. 281(11): 7237--7243 Smoothened regulates activator and repressor functions of Hedgehog signaling via two distinct mechanisms. [FBrf0190897] Ren et al., 2006, Genetics 172(3): 1643--1653 The shavenoid gene of Drosophila encodes a novel actin cytoskeleton interacting protein that promotes wing hair morphogenesis. [FBrf0190766] Rives et al., 2006, Dev. Biol. 293(1): 268--283 Endocytic trafficking of Wingless and its receptors, Arrow and DFrizzled-2, in the Drosophila wing. [FBrf0190155] Speder et al., 2006, Nature 440(7085): 803--807 Type ID unconventional myosin controls left-right asymmetry in Drosophila. [FBrf0191256] Strutt et al., 2006, Curr. Biol. 16(13): 1329--1336 Planar polarity is positively regulated by casein kinase Iepsilon in Drosophila. [FBrf0191945] Thompson and Cohen, 2006, Cell 126(4): 767--774 The hippo pathway regulates the bantam microRNA to control cell proliferation and apoptosis in Drosophila. [FBrf0193861] Tsuda et al., 2006, FEBS Lett. 580(13): 3296--3300 POSH, a scaffold protein for JNK signaling, binds to ALG-2 and ALIX in Drosophila. [FBrf0195280] Venkei et al., 2006, J. Cell Sci. 119(15): 3238--3248 alpha 4-tubulin is involved in rapid formation of long microtubules to push apart the daughter centrosomes during early Drosophila embryogenesis. [FBrf0192391] Walters et al., 2006, Dev. Biol. 297(2): 323--339 Planar polarization of the denticle field in the Drosophila embryo: roles for Myosin II (Zipper) and Fringe. [FBrf0200191] Ward et al., 2006, Curr. Biol. 16(23): 2352--2358 Stem cells signal to the niche through the Notch pathway in the Drosophila ovary. [FBrf0194773] Yasunaga et al., 2006, Mech. Dev. 123(12): 893--906 Fate map of the distal portion of Drosophila proboscis as inferred from the expression and mutations of basic patterning genes. [FBrf0194566] Zhou et al., 2006, Genetics 173(4): 2049--2062 The contributions of protein kinase A and smoothened phosphorylation to hedgehog signal transduction in Drosophila melanogaster. [FBrf0193965] Show all research papers ...

Dmel\P{GawB}ptc559.1 Insertion

Dmel\P{GawB}ptc^559.1 Insertion