Dsil\Loa

General Information
Symbol	Dsil\Loa	Species	D.silvestris
Name	Loa element	FlyBase ID	FBte0000284
Feature type	natural transposable element	Created / Updated	2006-12-04/2006-12-04
Sequences & Components
Complete element (bp)
Terminal repeat (bp)
Reference sequence	transposon_sequence_set.embl.txt.gz
Component genes
Sequence Accessions
	DDBJ/EMBL/GenBank X60177 X60176 X60175 X60174
Sequence Ontology (SO)
Transposon type	transposable_element
Insertions & Copy Number
Copy number and comments
Search for	All insertions of this transposon Insertions in the sequenced genome Insertions in other genomes
Target Site Duplication
Size (bp)
Orthologs
Curated drosophilid orthologs	Dpin\Loa (Biemont and Cizeron, 1999) Dpla\Loa Ddif\Loa Dpic\Loa Dhet\Loa
Comments
	Distribution of the LOA element is studied in several species of the Hawaiian Drosophila. An inverse correlation between the copy number and the age of the island on which the species is epidemic exists suggesting a relationship between speciation and the activity of the transposable element. (Wisotzkey et al., 1997) The Dsil\Loa element is an interspersed sequence isolated from the genome of D.silvestris, and appears to be a member of the non-LTR class of retrotransposons. It is 7.7kb long and its 3' end consists of TAA tandem repeats. Most elements are truncated at the 5' end and contain deletions. The Dsil\Loa element contains two overlapping open reading frames (ORFs). Two 'cys' motifs characteristic of gag proteins are found in ORF1, and ORF2 has similarities with retroviral pol genes, containing three presumptive protein domains in the following order: 5'-protease-reverse transcriptase-integrase-3'. (Felger and Hunt, 1992)
Other Information
Etymology

External Crossreferences
Sequence Crossreferences
	DDBJ/EMBL/GenBank X60177 X60176 X60175 X60174
Other Crossreferences

Synonyms & Secondary IDs ( 5 )
Reported As
Symbol Synonym	Dsil\Loa Dsil\U28T2 LOA (Berezikov et al., 2000, Losada et al., 1999, Wisotzkey et al., 1997, Blesa and Martinez-Sebastian, 1997, Felger and Hunt, 1992)
Name Synonym	Loa element U28T2 element
Secondary FlyBase IDs
	FBgn0005582 FBgn0005661
References ( 10 )
Research paper	Blesa et al., 2001, Molec. Biol. Evol. 18(4): 585--592 Distribution of the bilbo Non-LTR Retrotransposon in Drosophilidae and its Evolution in the Drosophila obscura Species Group. [FBrf0134760] Berezikov et al., 2000, GenomeBiol. 1(6): RESEARCH0011.1--0011.15 A search for reverse transcriptase-coding sequences reveals new non-LTR retrotransposons in the genome of Drosophila melanogaster. [FBrf0134666] Biemont and Cizeron, 1999, Genetica 105(1): 43--62 Distribution of transposable elements in Drosophila species. [FBrf0111330] Losada et al., 1999, Molec. Biol. Evol. 16(10): 1341--1346 The analysis of circe, an LTR retrotransposon of Drosophila melanogaster, suggests that an insertion of non-LTR retrotransposons into LTR elements can create chimeric retroelements. [FBrf0111953] Malik et al., 1999, Molec. Biol. Evol. 16(6): 793--805 The age and evolution of non-LTR retrotransposable elements. [FBrf0108898] Blesa and Martinez-Sebastian, 1997, Molec. Biol. Evol. 14(11): 1145--1153 bilbo, a non-LTR retrotransposon of Drosophila subobscura: a clue to the evolution of LINE-like elements in Drosophila. [FBrf0099127] Losada et al., 1997, Chromosoma 106(8): 503--512 Organization of DNA sequences near the centromere of the Drosophila melanogaster Y chromosome. [FBrf0100365] Wisotzkey et al., 1997, Chromosoma 106(7): 465--477 Biogeographic analysis of the UHU and LOA elements in the Hawaiian Drosophila. [FBrf0099782] Felger and Hunt, 1993, Methods Enzymol. 224: 322--334 Detection and characterization of transposable elements. [FBrf0068485] Felger and Hunt, 1992, Genetica 85: 119--130 A non-LTR retrotransposon from the Hawaiian Drosophila: the LOA element. [FBrf0056170]