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Citation	Kojima, T., Tsuji, T., Saigo, K. (2005). A concerted action of a paired-type homeobox gene, aristaless, and a homolog of Hox11/tlx homeobox gene, clawless, is essential for the distal tip development of the Drosophila leg. Dev. Biol. 279(2): 434--445.
FlyBase ID	FBrf0183860
Type of publication	Research paper
Offprint Available	No
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PubMed ID	15733670
PubMed Abstract	The subdivision of the developing field by region-specific expression of genes encoding transcription factors is an essential step during appendage development in arthropod and vertebrates. In Drosophila leg development, the distal-most region (pretarsus) is specified by the expression of homeobox genes, aristaless and Lim1, and its immediate neighbor (distal tarsus) is specified by the expression of a pair of Bar homeobox genes. Here, we show that one additional gene, clawless, which is a homolog of vertebrate Hox11/tlx homeobox gene family and formerly known as C15, is specifically expressed in the pretarsus and cooperatively acts with aristaless to repress Bar and possibly to activate Lim1. Similar to aristaless, the maximal expression of clawless requires Lim1 and its co-factor, Chip. Bar attenuates aristaless and clawless expression through Lim1 repression. Aristaless and Clawless proteins form a complex capable of binding to specific DNA targets, which cannot be well recognized solely by Aristaless or Clawless.
Biosis	2005.10002966
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Language of publication	English
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Abbreviation	Dev. Biol.
Title	Developmental Biology
Authors
Volume range	1-
Year range	1959-
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Place of publication	New York
Language of publication	English
ISBN/ISSN	0012-1606
CODEN	DEBIAO
Data from Reference
Aberrations (5)
	Ab(2;?)al^ice Df(3R)e-F1 Df(3R)e-GC3 Df(3R)e-H4 Df(3R)e-R1
Alleles (13)
	Avic\GFP^Scer\UAS B-H1^Scer\UAS.cSa C15^Scer\UAS.cKa C15^cll-dl92 Chi^e5.5 Ecol\lacZ^Lim1-P0092 Lim1^7B2 Lim1^Scer\UAS.cTa Scer\GAL4^dpp.blk1 al^Scer\UAS.cKa al^ex al^ice w^+mC
Constructs (6)
	P{GAL4-dpp.blk1} P{UAS-B-H1.S} P{UAS-C15.K} P{UAS-GFP.U} P{UAS-Lim1.T} P{UAS-al.K}
Genes (12)
	Avic\GFP B-H1 C15 CG7056 CG7922 Chi Ecol\lacZ Lim1 Scer\GAL4 al lbe w
Insertions (3)
	P{UAS-C15.K}m212M P{UAS-C15.K}m22M P{lArB}Lim1^P0092