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Reference
Citation	Aravin, A.A., Lagos-Quintana, M., Yalcin, A., Zavolan, M., Marks, D., Snyder, B., Gaasterland, T., Meyer, J., Tuschl, T. (2003). The small RNA profile during Drosophila melanogaster development. Dev. Cell 5(2): 337--350.
FlyBase ID	FBrf0162058
Type of publication	Research paper
Offprint Available	Yes
External Crossreferences
PubMed ID	12919683
PubMed Abstract	Small RNAs ranging in size between 20 and 30 nucleotides are involved in different types of regulation of gene expression including mRNA degradation, translational repression, and chromatin modification. Here we describe the small RNA profile of Drosophila melanogaster as a function of development. We have cloned and sequenced over 4000 small RNAs, 560 of which have the characteristics of RNase III cleavage products. A nonredundant set of 62 miRNAs was identified. We also isolated 178 repeat-associated small interfering RNAs (rasiRNAs), which are cognate to transposable elements, satellite and microsatellite DNA, and Suppressor of Stellate repeats, suggesting that small RNAs participate in defining chromatin structure. rasiRNAs are most abundant in testes and early embryos, where regulation of transposon activity is critical and dramatic changes in heterochromatin structure occur.
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Language of publication	English
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Abbreviation	Dev. Cell
Title	Developmental Cell
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Volume range	1-
Year range	2001-
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Place of publication	Cambridge, MA
Language of publication	English
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Data from Reference
Genes
	Su(Ste) ban iab-4 let-7 mir-1 mir-10 mir-100 mir-10S mir-11 mir-12 mir-124 mir-125 mir-133 mir-13a mir-13aS mir-13b-1 mir-13b-2 mir-14 mir-184 mir-184S mir-210 mir-263b mir-275 mir-276a mir-276b mir-277 mir-278 mir-279 mir-281a mir-281b mir-281bS mir-283 mir-285 mir-286 mir-2a-1 mir-2a-2 mir-2b-1 mir-2b-2 mir-2c mir-3 mir-303 mir-304 mir-305 mir-306 mir-306S mir-307 mir-308 mir-309 mir-310 mir-311 mir-312 mir-313 mir-314 mir-315 mir-316 mir-317 mir-318 mir-31a mir-31b mir-34 mir-4 mir-4S mir-5 mir-6-1 mir-6-2 mir-6-3 mir-7 mir-79 mir-8 mir-87 mir-8S mir-92a mir-92b mir-9a mir-9b mir-9c mir-iab-4-3p mir-iab-4-5p satDNA
Natural transposons
	1360 17.6 1731 3S18 412 BS Cr1a Doc3-element F-element G-element GATE HMS-Beagle HeT-A Ivk Max-element McClintock Quasimodo R1-element Rt1a Rt1b Rt1c Stalker TART-element X-element accord aurora-element baggins blood copia diver gypsy3 hopper2 invader1 invader4 mdg3 opus roo rooA springer transib4
Transcripts
	let-7-XR mir-1-XR mir-10-XR mir-100-XR mir-124-XR mir-125-XR mir-133-XR mir-278-XR mir-283-XR mir-2a-1-XR mir-2a-2-XR mir-3-XR mir-310-XR mir-311-XR mir-312-XR mir-4-XR mir-6-1-XR mir-6-2-XR mir-6-3-XR mir-7-XR mir-8-XR mir-9a-XR