Reference Report

Reference
Citation	Brennecke, J., Hipfner, D.R., Stark, A., Russell, R.B., Cohen, S.M. (2003). bantam encodes a developmentally regulated microRNA that controls cell proliferation and regulates the proapoptotic gene hid in Drosophila. Cell 113(1): 25--36.
FlyBase ID	FBrf0158764
Type of publication	Research paper
Offprint Available	Yes
External Crossreferences
PubMed ID	12679032
PubMed Abstract	Cell proliferation, cell death, and pattern formation are coordinated in animal development. Although many proteins that control cell proliferation and apoptosis have been identified, the means by which these effectors are linked to the patterning machinery remain poorly understood. Here, we report that the bantam gene of Drosophila encodes a 21 nucleotide microRNA that promotes tissue growth. bantam expression is temporally and spatially regulated in response to patterning cues. bantam microRNA simultaneously stimulates cell proliferation and prevents apoptosis. We identify the pro-apoptotic gene hid as a target for regulation by bantam miRNA, providing an explanation for bantam's anti-apoptotic activity.
Biosis	2003.261439
Zoological record
Associated Information
Comments
Text of personal communication
Associated files
Related Publications
Personal communication to FlyBase	Tub-EGFP query. Cohen, 2003, Tub-EGFP query. [FBrf0159688]
Also Published As

Other Reference Information
Secondary IDs
Language of publication	English
Additional language(s) of abstract
ISBN
Place of publication
Published In
Abbreviation	Cell
Title	Cell
Authors
Volume range	1-
Year range	1974-
Page range
Publisher	Cell Press
Place of publication	Cambridge, MA
Language of publication	English
ISBN/ISSN	0092-8674
CODEN	CELLB5
Data from Reference
Aberrations (1)
	Df(3L)ban^Δ1
Alleles (32)
	Avic\GFP^E.Scer\UAS Avic\GFP^{EGFP.W.3'UTR.αTub84B} Avic\GFP^{EGFP.W.3'UTRmut.αTub84B} Avic\GFP^{EGFP.ban.αTub84B} Avic\GFP^{EGFP.αTub84B.B} BEST:RE64518^EPg35007 BEST:RE64518^Scer\UAS.cBa BEST:RE64518^t6.7 BEST:RE64518^t9.6 Dp^Scer\UAS.cDa E2f^Scer\UAS.cNa Scer\GAL4^Act5C.PI Scer\GAL4^GMR.PF Scer\GAL4^arm.PS Scer\GAL4^en-e16E Scer\GAL4^ptc-559.1 Scer\GAL4^unspecified T:Avic\GFP^EGFP W^Ala5.GMR W^EP30060 W^GMR.PG ban^+t6.7 ban^+t9.6 ban^A.Scer\UAS ban^{C.Scer\UAS.T:Avic\GFP-EGFP} ban^{D.Scer\UAS.T:Avic\GFP-EGFP} ban^EP3622 ban^EPg30491 ban^L1170a fz2^{ECD.GPI.Scer\UAS.T:Hsap\MYC} nkd^Scer\UAS.cZa rpr^GMR.PH
Constructs (21)
	P{Act5C-GAL4} P{GAL4-arm.S} P{GAL4-ninaE.GMR} P{GMR-hid.Ala5} P{GMR-hid} P{GMR-rpr.H} P{Tub-EGFP.B} P{Tub-EGFP.ban} P{Tub-EGFP.hid.3'UTRmut} P{Tub-EGFP.hid} P{UAS-A} P{UAS-B} P{UAS-C} P{UAS-Dp.D} P{UAS-D} P{UAS-E2f.N} P{UAS-fz2(ECD)-GPI} P{UAS-nkd.Z} P{ban^+t6.7} P{ban^+t9.6} P{tub-EGFP.W.3'UTR}
Genes (12)
	Avic\GFP BEST:RE64518 Dp E2f Scer\GAL4 T:Avic\GFP T:Hsap\MYC W ban fz2 nkd rpr
Insertions (5)
	P{EPg}BEST:RE64518^EPg35007 P{EP}W^EP30060 P{GawB}ptc^559.1 P{en2.4-GAL4}e16E P{lacW}ban^L1170a
Transcripts (1)
	ban-XR