HomeReference Report
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| Citation | Lagos-Quintana, M., Rauhut, R., Lendeckel, W., Tuschl, T. (2001). Identification of novel genes coding for small expressed RNAs. Science 294(5543): 853--858. |
| FlyBase ID | FBrf0141757 |
| Type of publication | Research paper |
| Offprint Available | Yes |
| External Crossreferences | |
| PubMed ID | 11679670 |
| PubMed Abstract | In Caenorhabditis elegans, lin-4 and let-7 encode 22- and 21-nucleotide (nt) RNAs, respectively, which function as key regulators of developmental timing. Because the appearance of these short RNAs is regulated during development, they are also referred to as small temporal RNAs (stRNAs). We show that many 21- and 22-nt expressed RNAs, termed microRNAs, exist in invertebrates and vertebrates and that some of these novel RNAs, similar to let-7 stRNA, are highly conserved. This suggests that sequence-specific, posttranscriptional regulatory mechanisms mediated by small RNAs are more general than previously appreciated. |
| Biosis | 2001.540192 |
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| Supplementary material | Supplemental Table 1. [FBrf0141817] |
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| Secondary IDs | |
| Language of publication | English |
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| Abbreviation | Science |
| Title | Science |
| Authors | |
| Volume range | 1- |
| Year range | 1895- |
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| Place of publication | Washington, DC |
| Language of publication | English |
| ISBN/ISSN | 0036-8075 |
| CODEN | SCIEAS |
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| Genes (22)
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