|
Reference
|
| Citation |
Zou, S., Meadows, S., Sharp, L., Jan, L.Y., Jan, Y.N. (2000). Genome-wide study of aging and oxidative stress response in Drosophila melanogaster. Proc. Natl. Acad. Sci. USA 97(25): 13726--13731. |
| FlyBase ID |
FBrf0131436 |
| Type of publication |
Research paper |
| Offprint Available |
No |
|
External Crossreferences
|
| PubMed ID |
11095759 |
| PubMed Abstract |
Aging is a universal but poorly understood biological process. Free radicals accumulate with age and have been proposed to
be a major cause of aging. We measured genome-wide changes in transcript levels as a function of age in Drosophila melanogaster
and compared these changes with those caused by paraquat, a free-radical generator. A number of genes exhibited changes in
transcript levels with both age and paraquat treatment. We also found genes whose transcript levels changed with age but not
with paraquat treatment. This study suggests that free radicals play an important role in regulating transcript levels in
aging but that they are not the only factors. This genome-wide survey also identifies candidates for molecular markers of
aging.
|
| Biosis |
2001.59302 |
| Zoological record |
|
Associated Information
|
| Comments |
|
| Text of personal communication |
|
| Associated files |
|
|
Related Publications
|
|
|
|
Also Published As
|
|
|
|
Other Reference Information
|
| Secondary IDs |
|
| Language of publication |
English |
| Additional language(s) of abstract |
|
| ISBN |
|
| Place of publication |
|
|
Published In
|
| Abbreviation |
Proc. Natl. Acad. Sci. USA |
| Title |
Proceedings of the National Academy of Sciences of the United States of America |
| Authors |
|
| Volume range |
1- |
| Year range |
1915- |
| Page range |
|
| Publisher |
|
| Place of publication |
Washington, DC |
| Language of publication |
English |
| ISBN/ISSN |
0027-8424 |
| CODEN |
PNASA6 |
|
Data from Reference
|
| Genes (118)
|
|
|
|
Home