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Reference
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| Citation |
Hedengren, M., Asling, B., Dushay, M.S., Ando, I., Ekengren, S., Wihlborg, M., Hultmark, D. (1999). Relish, a central factor in the control of humoral but not cellular immunity in Drosophila. Molec. Cell 4(5): 827--837. |
| FlyBase ID |
FBrf0123041 |
| Type of publication |
Research paper |
| Offprint Available |
Yes |
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External Crossreferences
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| PubMed ID |
10619029 |
| PubMed Abstract |
The NF-kappa B-like Relish gene is complex, with four transcripts that are all located within an intron of the Nmdmc gene.
Using deletion mutants, we show that Relish is specifically required for the induction of the humoral immune response, including
both antibacterial and antifungal peptides. As a result, the Relish mutants are very sensitive to infection. A single cell
of E. cloacae is sufficient to kill a mutant fly, and the mutants show increased susceptibility to fungal infection. In contrast,
the blood cell population, the hematopoietic organs, and the phagocytic, encapsulation, and melanization responses are normal.
Our results illustrate the importance of the humoral response in Drosophila immunity and demonstrate that Relish plays a key
role in this response.
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| Biosis |
2000.49431 |
| Zoological record |
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Associated Information
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| Text of personal communication |
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Related Publications
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Also Published As
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Other Reference Information
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| Secondary IDs |
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| Language of publication |
English |
| Additional language(s) of abstract |
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Published In
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| Abbreviation |
Molec. Cell |
| Title |
Molecular Cell |
| Authors |
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| Volume range |
1- |
| Year range |
1997- |
| Page range |
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| Publisher |
Cell Press |
| Place of publication |
Cambridge, MA |
| Language of publication |
English |
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Data from Reference
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| Alleles (16)
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| Constructs (2)
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| Genes (18)
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| Insertions (3)
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