A Database of Drosophila Genes & Genomes

FB2008_07, released August 8, 2008
 

Reference Report

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Citation Bohni, R., Riesgo-Escovar, J., Oldham, S., Brogiolo, W., Stocker, H., Andruss, B.F., Beckingham, K., Hafen, E. (1999). Autonomous control of cell and organ size by CHICO, a Drosophila homolog of vertebrate IRS1-4.  Cell 97(7): 865--875.
FlyBase ID FBrf0108621
Type of publication Research paper
Offprint Available Yes
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PubMed ID 10399915
PubMed Abstract The control of growth is fundamental to the developing metazoan. Here, we show that CHICO, a Drosophila homolog of vertebrate IRS1-4, plays an essential role in the control of cell size and growth. Animals mutant for chico are less than half the size of wild-type flies, owing to fewer and smaller cells. In mosaic animals, chico homozygous cells grow slower than their heterozygous siblings, show an autonomous reduction in cell size, and form organs of reduced size. Although chico flies are smaller, they show an almost 2-fold increase in lipid levels. The similarities of the growth defects caused by mutations in chico and the insulin receptor gene in Drosophila and by perturbations of the insulin/IGF1 signaling pathway in vertebrates suggest that this pathway plays a conserved role in the regulation of overall growth by controling cell size, cell number, and metabolism.
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Zoological record 13602000580
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Language of publication English
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Abbreviation Cell
Title Cell
Authors
Volume range 1-
Year range 1974-
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Publisher Cell Press
Place of publication Cambridge, MA
Language of publication English
ISBN/ISSN 0092-8674
CODEN CELLB5
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