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Reference
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| Citation |
Baba, K., Takeshita, A., Majima, K., Ueda, R., Kondo, S., Juni, N., Yamamoto, D. (1999). The Drosophila Bruton's tyrosine kinase (Btk) homolog is required for adult survival and male genital formation. Molec. Cell. Biol. 19(6): 4405--4413. |
| FlyBase ID |
FBrf0108136 |
| Type of publication |
Research paper |
| Offprint Available |
Yes |
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External Crossreferences
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| PubMed ID |
10330180 |
| PubMed Abstract |
We isolated a Drosophila fickleP (ficP) mutant with a shortened copulatory duration and reduced adult-stage life span. The
reduced copulatory duration is ascribable to incomplete fusion of the left and right halves of the apodeme that holds the
penis during copulation. ficP is an intronic mutation occurring in the Btk gene, a gene which encodes two forms (type 1 and
type 2) of a Bruton's tyrosine kinase (Btk) family cytoplasmic tyrosine kinase as a result of alternative exon usage. The
ficP mutation prevents the formation of the type 2 isoform but leaves expression of the type 1 transcript intact. Ubiquitous
overexpression of the wild-type cDNA by using a heat shock 70 promoter during the late larval or pupal stages rescued the
life span and genital defects in the mutant, respectively, establishing the causal relationship between the ficP phenotypes
and the Btk gene mutation. The stage specificity of the rescuing ability suggests that the Btk gene is required for the development
of male genitalia and substrates required for adult survival.
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Associated Information
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| Text of personal communication |
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Also Published As
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Other Reference Information
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| Secondary IDs |
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| Language of publication |
English |
| Additional language(s) of abstract |
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| ISBN |
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Published In
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| Abbreviation |
Molec. Cell. Biol. |
| Title |
Molecular and Cellular Biology |
| Authors |
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| Volume range |
1- |
| Year range |
1981- |
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| Publisher |
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| Place of publication |
Washington, DC |
| Language of publication |
English |
| ISBN/ISSN |
0270-7306 |
| CODEN |
MCEBD4 |
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Data from Reference
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| Aberrations (1)
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| Alleles (9)
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| Constructs (2)
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| Genes (2)
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| Insertions (1)
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