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Reference
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| Citation |
Wolfner, M.F., Harada, H.A., Bertram, M.J., Stelick, T.J., Kraus, K.W., Kalb, J.M., Lung, Y.O., Neubaum, D.M., Park, M., Tram, U. (1997). New genes for male accessory gland proteins in Drosophila melanogaster. Insect Biochem. Molec. Biol. 27(10): 825--834. |
| FlyBase ID |
FBrf0100648 |
| Type of publication |
Research paper |
| Offprint Available |
Yes |
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External Crossreferences
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| PubMed ID |
9474779 |
| PubMed Abstract |
The accessory gland of male insects produces components of the seminal fluid that alter the behavior, physiology and life
span of the mated female, and contribute to her efficient storage and utilization of sperm. As a step towards understanding
how this occurs, we have isolated genes encoding 12 previously unreported accessory gland-specific mRNAs from the fruit fly
Drosophila melanogaster. We report here the restriction maps of the new genes, the chromosome positions--which are all autosomal--of
the 11 non-repetitive genes, their expression patterns, and the sequences of the accessory gland proteins (Acps) encoded by
nine of the genes. Eight of the proteins predicted from these sequences begin with putative secretion signals. Following their
signal sequences, three of the predicted molecules are peptides and the other five are larger polypeptides with characteristics
of cleavable prohormones. The ninth molecule, which has an N-terminal hydrophobic region but no consensus signal peptide cleavage
site, is predicted to be a 716 amino acid glycoprotein. Of the nine proteins, two have intriguing similarities to sequences
in protein databases. Acp76A is a 388 amino acid pro-protein which contains a signature sequence for the serpin class of protease
inhibitors. The 115 amino acid Acp62F has a 28 amino acid region of high sequence similarity to a neurotoxin of the Brazilian
armed spider Phoneutria nigriventer. Models are discussed in which Acp76A plays a role in the observed regulation of Acp proteolysis
and/or in the coagulation of seminal fluid to form a mating plug, and in which Acp62F contributes to the reported toxicity
of Drosophila seminal fluid.
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| Biosis |
1135348 |
| Zoological record |
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Associated Information
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| Comments |
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| Text of personal communication |
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Also Published As
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Other Reference Information
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| Secondary IDs |
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| Language of publication |
English |
| Additional language(s) of abstract |
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| ISBN |
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| Place of publication |
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Published In
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| Abbreviation |
Insect Biochem. Molec. Biol. |
| Title |
Insect Biochemistry and Molecular Biology |
| Authors |
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| Volume range |
22- |
| Year range |
1992- |
| Page range |
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| Publisher |
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| Place of publication |
Bristol |
| Language of publication |
English |
| ISBN/ISSN |
0965-1748 |
| CODEN |
IBMBES |
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Data from Reference
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| Genes (15)
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