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Citation	Gorfinkiel, N., Morata, G., Guerrero, I. (1997). The homeobox gene Distal-less induces ventral appendage development in Drosophila. Genes Dev. 11(17): 2259--2271.
FlyBase ID	FBrf0098249
Type of publication	Research paper
Offprint Available	Yes
External Crossreferences
PubMed ID	9303541
PubMed Abstract	This study investigates the role of the homeobox gene Distal-less (Dll) in the development of the legs, antennae, and wings of Drosophila. Lack of Dll function causes a change in the identity of ventral appendage cells (legs and antennae) that often results in the loss of the appendage. Ectopic Dll expression in the proximal region of ventral appendages induces nonautonomous duplication of legs and antennae by the activation of wingless and decapentaplegic. Ectopic Dll expression in dorsal appendages produces transformation into corresponding ventral appendages; wings and halteres develop ectopic legs and the head-eye region develops ectopic antennae. In the wing, the exogenous Dll product induces this transformation by activating the endogenous Dll gene and repressing the wing determinant gene vestigial. It is proposed that Dll induces the development of ventral appendages and also participates in a genetic address that specifies the identity of ventral appendages and discriminates the dorsal versus the ventral appendages in the adult. However, unlike other homeotic genes, Dll expression and function is not defined by a cell lineage border. Dll also performs a secondary and late function required for the normal patterning of the wing.
Biosis	99752800
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Language of publication	English
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Abbreviation	Genes Dev.
Title	Genes & Development
Authors
Volume range	1-
Year range	1987-
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Place of publication	Cold Spring Harbor, NY
Language of publication	English
ISBN/ISSN	0890-9369
CODEN	GEDEEP
Data from Reference
Aberrations (1)
	Df(2R)Dll-MP
Alleles (27)
	Dll¹⁴ Dll¹⁷ Dll³ Dll^Scer\UAS.cGa Dll^em212 Ecol\lacZ^Dll-01092 Ecol\lacZ^ap-rK568 Ecol\lacZ^arm.PV Ecol\lacZ^{bab1-A128.1F3} Ecol\lacZ^dpp.BS3.0 Ecol\lacZ^wg-en11 Scer\FLP1^hs.PS Scer\GAL4^Act5C.PP Scer\GAL4^Bx-MS1096 Scer\GAL4^C-68a Scer\GAL4^C-765 Scer\GAL4^Dll-MD728 Scer\GAL4^Dll-em212 Scer\GAL4^Dll-md23 Scer\GAL4^{Scer\FRT.Rnor\CD2.Act5C} Scer\GAL4^ap-md544 Scer\GAL4^bi-omb-Gal4 Scer\GAL4^dpp.blk1 Scer\GAL4^ptc-559.1 Scer\GAL4^upd-E132 w^+mC y^Scer\UAS.cCa
Constructs (8)
	P{BS3.0} P{GAL4-Act5C(-FRT).P} P{GAL4-Act5C(FRT.CD2).P} P{GAL4-dpp.blk1} P{UAS-Dll.G} P{UAS-y.C} P{arm-lacZ.V} P{hsp70-flp}
Genes (9)
	Dll Ecol\lacZ Scer\FLP1 Scer\GAL4 en vg w wg y
Insertions (14)
	P{GAL4}C-68a P{GAL4}MD728 P{GAL4}bi^omb-Gal4 P{GawB}Bx^MS1096 P{GawB}C-765 P{GawB}Dll^em212 P{GawB}Dll^md23 P{GawB}E132 P{GawB}ap^md544 P{GawB}ptc^559.1 P{PZ}Dll⁰¹⁰⁹² P{PZ}ap^rK568 P{en1}wg^en11 P{lArB}bab1^A128.1F3