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Reference
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| Citation |
Warren, W.D., Palmer, S., Howells, A.J. (1996). Molecular characterization of the cinnabar region of Drosophila melanogaster: identification of the cinnabar transcription
unit. Genetica 98(3): 249--262.
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| FlyBase ID |
FBrf0097723 |
| Type of publication |
Research paper |
| Offprint Available |
Yes |
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External Crossreferences
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| PubMed ID |
9204549 |
| PubMed Abstract |
Early studies of eye pigmentation in Drosophila melanogaster provided compelling evidence that the cinnabar (cn) gene encodes
the enzyme kynurenine 3-monooxygenase (EC 1.14.13.9). Here we report the cloning of approximately 60 kb of DNA encompassing
the cn gene by chromosome walking in the 43E6-F1 region of chromosome 2. An indication of the position of cn within the cloned
region was obtained by molecular analysis of mutants: 9 spontaneous cn mutants were found to have either DNA insertions or
deletions within a 5 kb region. In addition, a 7.8 kb restriction fragment encompassing the region altered in the mutants
was observed to induce transient cn function when microinjected into cn- embryos. The cn transcription unit was identified
by Northern blotting and sequence analysis of cDNA and genomic clones from this region. The predicted cn protein contains
several sequence motifs common to aromatic monooxygenases and is consistent with the assignment of cn as encoding the structural
gene for kynurenine 3-monooxygenase.
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| Biosis |
99645292 |
| Zoological record |
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Associated Information
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| Comments |
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| Text of personal communication |
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| Associated files |
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Related Publications
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Also Published As
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Other Reference Information
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| Secondary IDs |
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| Language of publication |
English |
| Additional language(s) of abstract |
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| ISBN |
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| Place of publication |
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Published In
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| Abbreviation |
Genetica |
| Title |
Genetica |
| Authors |
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| Volume range |
1- |
| Year range |
1919- |
| Page range |
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| Publisher |
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| Place of publication |
Dordrecht |
| Language of publication |
English |
| ISBN/ISSN |
0016-6707 |
| CODEN |
GENEA3 |
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Data from Reference
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| Aberrations (4)
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| Alleles (15)
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| Genes (3)
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