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Reference
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| Citation |
Vorbruggen, G., Jackle, H. (1997). Epidermal muscle attachment site-specific target gene expression and interference with myotube guidance in response to ectopic
stripe expression in the developing Drosophila epidermis. Proc. Natl. Acad. Sci. USA 94(16): 8606--8611. |
| FlyBase ID |
FBrf0097704 |
| Type of publication |
Research paper |
| Offprint Available |
Yes |
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External Crossreferences
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| PubMed ID |
9238024 |
| PubMed Abstract |
The egr-type zinc-finger transcription factor encoded by the Drosophila gene stripe (sr) is expressed in a subset of epidermal
cells to which muscles attach during late stages of embryogenesis. We report loss-of-function and gain-of-function experiments
indicating that sr activity provides ectodermal cells with properties required for the establishment of a normal muscle pattern
during embryogenesis and for the differentiation of tendon-like epidermal muscle attachment sites (EMA). Our results show
that sr encodes a transcriptional activator which acts as an autoregulated developmental switch gene. sr activity controls
the expression of EMA-specific target genes in cells of ectodermal but not of mesodermal origin. sr-expressing ectodermal
cells generate long-range signals that interfere with the spatial orientation of the elongating myotubes.
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| Biosis |
99707955 |
| Zoological record |
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Associated Information
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| Comments |
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| Text of personal communication |
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| Associated files |
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Related Publications
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Also Published As
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Other Reference Information
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| Secondary IDs |
FBrf0098112 |
| Language of publication |
English |
| Additional language(s) of abstract |
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| ISBN |
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| Place of publication |
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Published In
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| Abbreviation |
Proc. Natl. Acad. Sci. USA |
| Title |
Proceedings of the National Academy of Sciences of the United States of America |
| Authors |
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| Volume range |
1- |
| Year range |
1915- |
| Page range |
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| Publisher |
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| Place of publication |
Washington, DC |
| Language of publication |
English |
| ISBN/ISSN |
0027-8424 |
| CODEN |
PNASA6 |
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Data from Reference
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| Alleles (9)
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| Constructs (5)
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| Genes (9)
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| Insertions (3)
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