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Reference
Citation	George, H., Terracol, R. (1997). The vrille gene of Drosophila is a maternal enhancer of decapentaplegic and encodes a new member of the bZIP family of transcription factors. Genetics 146(4): 1345--1363.
FlyBase ID	FBrf0094777
Type of publication	Research paper
Offprint Available	Yes
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PubMed ID	9258679
PubMed Abstract	We report here the genetical and molecular characterization of a new Drosophila zygotic lethal locus, vrille (vri). Vri alleles act not only as dominant maternal enhancers of embryonic dorsoventral patterning defects caused by easter and decapentaplegic (dpp) mutations, but also as dominant zygotic enhancers of dpp alleles for phenotypes in wing. The vri gene encodes a new member of the bZIP family of transcription factors closely related to gene 9 of Xenopus laevis, induced by thyroid hormone during the tadpole tail resorption program, and NF-IL3A, a human T cell transcription factor that transactivates the interleukin-3 promoter. NF-IL3A shares 93% similarity and 60% identity with Vri for a stretch of 68 amino acids that includes the bZIP domain. Although all the alleles tested behave like antimorphs, the dominant enhancement is also seen with a nonsense mutation allele that prevents translation of the bZIP domain. Because of the strong domainant enhancement of dpp phenotypes by vri alleles in both embryo and wing, and also the similarity between the wing vein phenotypes caused by the vri and shortvein dpp alleles, we postulate that vri interacts either directly or indirectly with certain components of the dpp (a TGF beta homologue) signal transduction pathway.
Biosis	99690601
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Language of publication	English
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Abbreviation	Genetics
Title	Genetics
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Volume range	1-
Year range	1916-
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Place of publication	Austin, TX, etc
Language of publication	English
ISBN/ISSN	0016-6731
CODEN	GENTAE
Data from Reference
Aberrations (9)
	Df(2L)cl-h2 Df(2L)cl1 Df(2L)cl7 Df(2L)tkv2 Df(2L)tkv3 Dp(2;1)B19 In(2L)tkv^Sz-1 Tp(2;1)B19 Tp(2;3)tkv
Alleles (43)
	Ecol\lacZ^cype-03771 Ecol\lacZ^tkv-04415 Ecol\lacZ^vri-k03801 Ecol\lacZ^vri-k05901 Ecol\lacZ^vri-k09602 Ecol\lacZ^vri-k09713 Ecol\lacZ^vri-k11805 Mad⁶ cype⁰³⁷⁷¹ dpp^d6 dpp^hr27 dpp^hr4 ea^161.13 nompC¹ nompC² nompC³ nompC⁴ nompC⁵ put¹³⁵ shn¹ tkv⁰⁴⁴¹⁵ tkv³ tkv^Ubi-p63E.PB tkv^k16713 vri¹ vri² vri³ vri^5R4.11 vri^5R5.24 vri^5R5.7 vri^5R7.2 vri^5R8.4 vri^K17 vri^SK10 vri^X5 vri^hs.PG vri^k03801 vri^k05901 vri^k09602 vri^k09713 vri^k11805 w^+mC w^+mW.hs
Constructs (5)
	P{Ubi-tkv-1} P{hs-vri.G} P{vri.K17} P{vri.SK10} P{vri.X5}
Genes (16)
	Bsg25D Ecol\lacZ Mad anon-25Da anon-25Db anon-25Dc cype dpp ea nompC put shn tkv vri w zen
Insertions (8)
	P{PZ}cype⁰³⁷⁷¹ P{PZ}tkv⁰⁴⁴¹⁵ P{lacW}tkv^k16713 P{lacW}vri^k03801 P{lacW}vri^k05901 P{lacW}vri^k09602 P{lacW}vri^k09713 P{lacW}vri^k11805