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Reference
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| Citation |
Becker, S., Pasca, G., Strumpf, D., Min, L., Volk, T. (1997). Reciprocal signaling between Drosophila epidermal muscle attachment cells and their corresponding muscles. Development 124(13): 2615--2622. |
| FlyBase ID |
FBrf0094132 |
| Type of publication |
Research paper |
| Offprint Available |
Yes |
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External Crossreferences
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| PubMed ID |
9217003 |
| PubMed Abstract |
Directed intercellular interactions between distinct cell types underlie the basis for organogenesis during embryonic development.
This paper focuses on the establishment of the final somatic muscle pattern in Drosophila, and on the possible cross-talk
between the myotubes and the epidermal muscle attachment cells, occurring while both cell types undergo distinct developmental
programs. Our findings suggest that the stripe gene is necessary and sufficient to initiate the developmental program of epidermal
muscle attachment cells. In stripe mutant embryos, these cells do not differentiate correctly. Ectopic expression of Stripe
in various epidermal cells transforms these cells into muscle-attachment cells expressing an array of epidermal muscle attachment
cell-specific markers. Moreover, these ectopic epidermal muscle attachment cells are capable of attracting somatic myotubes
from a limited distance, providing that the myotube has not yet been attached to or been influenced by a closer wild-type
attachment cell. Analysis of the relationships between muscle binding and differentiation of the epidermal muscle attachment
cell was performed in mutant embryos in which loss of muscles, or ectopic muscles were induced. This analysis indicated that,
although the initial expression of epidermal muscle-attachment cell-specific genes including stripe and groovin is muscle
independent, their continuous expression is maintained only in epidermal muscle attachment cells that are connected to muscles.
These results suggest that the binding of a somatic muscle to an epidermal muscle attachment cell triggers a signal affecting
gene expression in the attachment cell. Taken together, our results suggest the presence of a reciprocal signaling mechanism
between the approaching muscles and the epidermal muscle attachment cells. First the epidermal muscle attachment cells signal
the myotubes and induce myotube attraction and adhesion to their target cells. Following this binding, the muscle cells send
a reciprocal signal to the epidermal muscle attachment cells inducing their terminal differentiation into tendon-like cells.
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| Biosis |
99687871 |
| Zoological record |
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Associated Information
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| Comments |
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| Text of personal communication |
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| Associated files |
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Related Publications
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Also Published As
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Other Reference Information
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| Secondary IDs |
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| Language of publication |
English |
| Additional language(s) of abstract |
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| ISBN |
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| Place of publication |
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Published In
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| Abbreviation |
Development |
| Title |
Development |
| Authors |
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| Volume range |
99- |
| Year range |
1987- |
| Page range |
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| Publisher |
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| Place of publication |
Cambridge |
| Language of publication |
English |
| ISBN/ISSN |
0950-1991 |
| CODEN |
DEVPED |
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Data from Reference
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| Aberrations (1)
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| Alleles (13)
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| Constructs (7)
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| Genes (11)
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| Insertions (3)
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