Reference Report

Reference
Citation	Sluss, H.K., Han, Z., Barrett, T., Goberdhan, D.C.I., Wilson, C., Davis, R.J., Ip, Y.T. (1996). A JNK signal transduction pathway that mediates morphogenesis and an immune response in Drosophila. Genes Dev. 10(21): 2745--2758.
FlyBase ID	FBrf0090803
Type of publication	Research paper
Offprint Available	No
External Crossreferences
PubMed ID	8946915
PubMed Abstract	The Drosophila MAP kinase DJNK is a homolog of the mammalian c-Jun amino-terminal kinase (JNK). Mutations in the DJNK gene correspond to the complementation group basket. DJNK is phosphorylated and activated by the Drosophila MAP kinase kinase HEP. Substrates of DJNK include the transcription factor DJun. DJNK participates in multiple physiological processes. Exposure to endotoxic lipopolysaccharide initiates an insect immune response and leads to DJNK activation. In addition, embryos lacking DJNK are defective in dorsal closure, a process in which the lateral epithelial cells migrate over the embryo and join at the dorsal midline. These data demonstrate that the DJNK signal transduction pathway mediates an immune response and morphogenesis in vivo.
Biosis	99319830
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Erratum	A JNK signal transduction pathway that mediates morphogenesis and an immune response in Drosophila. Sluss et al., 1997, Genes Dev. 11(4): 541 [FBrf0092866]
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Secondary IDs
Language of publication	English
Additional language(s) of abstract
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Published In
Abbreviation	Genes Dev.
Title	Genes & Development
Authors
Volume range	1-
Year range	1987-
Page range
Publisher
Place of publication	Cold Spring Harbor, NY
Language of publication	English
ISBN/ISSN	0890-9369
CODEN	GEDEEP
Data from Reference
Aberrations (6)
	Df(2L)J106 Df(2L)J77 Df(2L)JR1 Df(2L)flp147E Df(2L)flp170B In(3LR)TM6
Alleles (7)
	bsk¹ bsk² bsk^{Act5C.T:Zzzz\FLAG} bsk^hs.PS chico¹ w^+mC y⁺
Balancers (1)
	TM6-y⁺
Constructs (1)
	P{DJNK}
Genes (10)
	J Jra T:Zzzz\FLAG bsk chico hep me31B rl w y