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Reference
Citation	Speicher, S.A., Thomas, U., Hinz, U., Knust, E. (1994). The Serrate locus of Drosophila and its role in morphogenesis of the wing imaginal discs: control of cell proliferation. Development 120(3): 535--544.
FlyBase ID	FBrf0074510
Type of publication	Research paper
Offprint Available	Yes
External Crossreferences
PubMed ID	8162853
PubMed Abstract	The Drosophila gene Serrate encodes a transmembrane protein with 14 EGF-like repeats in its extracellular domain. Here we show that loss-of-function mutations in this gene lead to larval lethality. Homozygous mutant larvae fail to differentiate the anterior spiracles, exhibit poorly developed mouth-hooks and show a severe reduction in the size of the wing and haltere primordia, which is not due to cell death. The few homozygous mutant escapers that pupariate develop into pharate adults that almost completely lack wings and halteres. Clonal analysis in the adult epidermis demonstrates a requirement for Serrate during wing and haltere development. Targeted ectopic expression of Serrate in the imaginal discs using the yeast transcriptional activator Gal4 results in regionally restricted induction of cell proliferation, e.g. the ventral tissues in the case of the wings and halteres. The results suggest that the wild-type function of Serrate is required for the control of position-specific cell proliferation during development of meso- and metathoracic dorsal discs, which in turn exerts a direct effect on morphogenesis.
Biosis	97191421
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Language of publication	English
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Abbreviation	Development
Title	Development
Authors
Volume range	99-
Year range	1987-
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Place of publication	Cambridge
Language of publication	English
ISBN/ISSN	0950-1991
CODEN	DEVPED
Data from Reference
Aberrations (1)
	Df(3R)Ser-RX3
Alleles (16)
	Scer\GAL4^h-540.3 Scer\GAL4^ptc-559.1 Ser¹ Ser^D Ser^RX106 Ser^RX107 Ser^RX82 Ser^Rx103 Ser^Rx111 Ser^Rx112 Ser^Rx119 Ser^Rx120 Ser^Rx50 Ser^Scer\UAS.cSa ap^56f w^+mC
Constructs (2)
	P{UAS-Ser.mg5603} pP{UAS-Ser.mg5603}
Genes (5)
	Scer\GAL4 Ser ap h vg
Insertions (2)
	P{GawB}h-540.3 P{GawB}ptc^559.1