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Reference
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| Citation |
Rasmusson, K., Serr, M., Gepner, J., Gibbons, I., Hays, T.S. (1994). A family of dynein genes in Drosophila melanogaster. Molec. Biol. Cell 5(1): 45--55. |
| FlyBase ID |
FBrf0074249 |
| Type of publication |
Research paper |
| Offprint Available |
Yes |
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External Crossreferences
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| PubMed ID |
8186464 |
| PubMed Abstract |
We report the identification and initial characterization of seven Drosophila dynein heavy chain genes. Each gene is single
copy and maps to a unique genomic location. Sequence analysis of partial clones reveals that each encodes a highly conserved
portion of the putative dynein hydrolytic ATP-binding site in dyneins that includes a consensus phosphate-binding (P-loop)
motif. One of the clones is derived from a Drosophila cytoplasmic dynein heavy chain gene, Dhc64C, that shows extensive amino
acid identity to cytoplasmic dynein isoforms from other organisms. Two other Drosophila dynein clones are 85 and 90% identical
at the amino acid level to the corresponding region of the beta heavy chain of sea urchin axonemal dynein. Probes for all
seven of the dynein-related sequences hybridize to transcripts that are of the appropriate size, approximately 14 kilobases,
to encode the characteristic high molecular weight dynein heavy chain polypeptides. The Dhc64C transcript is readily detected
in RNA from ovaries, embryos, and testes. Transcripts from five of the six remaining genes are also detected in much lesser
amounts in tissues other than testes. All but one of the dynein transcripts are expressed at comparable levels in testes suggesting
their participation in flagellar axoneme assembly and motility.
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| Biosis |
97191351 |
| Zoological record |
13003011888 |
Associated Information
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| Comments |
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| Text of personal communication |
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Related Publications
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Also Published As
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Other Reference Information
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| Secondary IDs |
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| Language of publication |
English |
| Additional language(s) of abstract |
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| ISBN |
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| Place of publication |
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Published In
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| Abbreviation |
Molec. Biol. Cell |
| Title |
Molecular Biology of the Cell |
| Authors |
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| Volume range |
3- |
| Year range |
1992- |
| Page range |
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| Publisher |
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| Place of publication |
Bethesda, MD |
| Language of publication |
English |
| ISBN/ISSN |
1059-1524 |
| CODEN |
MBCEEV |
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Data from Reference
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| Genes (7)
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