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Reference
Citation	Hinz, U., Giebel, B., Campos-Ortega, J.A. (1994). The basic-helix-loop-helix domain of Drosophila lethal of scute protein is sufficient for proneural function and activates neurogenic genes. Cell 76(1): 77--87.
FlyBase ID	FBrf0068528
Type of publication	Research paper
Offprint Available	No
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PubMed ID	8287481
PubMed Abstract	The development of most epidermal sensory organs in Drosophila is controlled by achaete and scute, two of the genes of the achaete-scute complex (AS-C). The genes of the AS-C encode members of the basic-helix-loop-helix (bHLH) class of transcriptional regulators, and their activity defines proneural cell clusters in the imaginal discs from which sensory organ mother cells are singled out by a process of lateral inhibition. Ectopic expression of lethal of scute, another member of the AS-C, normally dispensable for sensory organ development in the adult, promotes this process independently of the activity of the other AS-C genes. This demonstrates a high degree of functional redundancy of the products of the AS-C. Furthermore, neurogenic genes are activated in ectopic proneural clusters, allowing development of epidermal progenitor cells. Finally, the bHLH domain is necessary and sufficient to mediate the proneural function, to activate neurogenic genes, and to allow lateral inhibition.
Biosis	97139682
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Language of publication	English
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Abbreviation	Cell
Title	Cell
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Volume range	1-
Year range	1974-
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Publisher	Cell Press
Place of publication	Cambridge, MA
Language of publication	English
ISBN/ISSN	0092-8674
CODEN	CELLB5
Data from Reference
Aberrations (3)
	Df(1)ase-1 Df(1)sc10-1 Df(2L)J27
Alleles (18)
	Ecol\lacZ^Scer\UAS.cFa Ecol\lacZ^neur-A101 Scer\GAL4^455.2 Scer\GAL4^527.3 Scer\GAL4^564.2 Scer\GAL4^ptc-559.1 Scer\GAL4^sca-537.4 da^IIP106 l(1)sc^Scer\UAS.cHa l(1)sc^YA.Scer\UAS l(1)sc^ΔB.Scer\UAS l(1)sc^{ΔC1.Scer\UAS} l(1)sc^{ΔC2.Scer\UAS} l(1)sc^{ΔHLH.Scer\UAS} l(1)sc^ΔN.Scer\UAS l(1)sc^{ΔNΔC2.Scer\UAS} sc^Scer\UAS.cHa w^+mC
Constructs (19)
	P{UAS-l(1)sc.LSC} P{UAS-l(1)sc.YA} P{UAS-l(1)sc.ΔB} P{UAS-l(1)sc.ΔC1} P{UAS-l(1)sc.ΔC2} P{UAS-l(1)sc.ΔHLH} P{UAS-l(1)sc.ΔN} P{UAS-l(1)sc.ΔNΔC2} P{UAS-lacZ.Hsp70} P{UAS-sc.USC} pP{UAS-l(1)sc.LSC} pP{UAS-l(1)sc.YA} pP{UAS-l(1)sc.ΔB} pP{UAS-l(1)sc.ΔC1} pP{UAS-l(1)sc.ΔC2} pP{UAS-l(1)sc.ΔHLH} pP{UAS-l(1)sc.ΔN} pP{UAS-l(1)sc.ΔNΔC2} pP{UAS-sc.USC}
Genes (12)
	Dl E(spl) Ecol\lacZ HLHm5 Scer\GAL4 ac ase da l(1)sc ptc sc w
Insertions (7)
	P{GawB}455.2 P{GawB}527.3 P{GawB}564.2 P{GawB}h-540.3 P{GawB}ptc^559.1 P{GawB}sca^537.4 P{lArB}neur^A101