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Reference
Citation	Ephrussi, A., Dickinson, L.K., Lehmann, R. (1991). Oskar organizes the germ plasm and directs localization of the posterior determinant nanos. Cell 66(1): 37--50.
FlyBase ID	FBrf0053367
Type of publication	Research paper
Offprint Available	Yes
External Crossreferences
PubMed ID	2070417
PubMed Abstract	Oskar is one of seven Drosophila maternal-effect genes that are necessary for germline and abdomen formation. We have cloned oskar and show that oskar RNA is localized to the posterior pole of the oocyte when germ plasm forms. This polar distribution of oskar RNA is established during oogenesis in three phases: accumulation in the oocyte, transport toward the posterior, and finally maintenance at the posterior pole of the oocyte. The colocalization of oskar and nanos in wild-type and bicaudal embryos suggests that oskar directs localization of the posterior determinant nanos. We propose that the pole plasm is assembled stepwise and that continued interaction among its components is required for germ cell determination.
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Zoological record	12900017426
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Language of publication	English
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Abbreviation	Cell
Title	Cell
Authors
Volume range	1-
Year range	1974-
Page range
Publisher	Cell Press
Place of publication	Cambridge, MA
Language of publication	English
ISBN/ISSN	0092-8674
CODEN	CELLB5
Data from Reference
Aberrations (2)
	Df(3R)p-XT103 Df(3R)p-XT118
Alleles (30)
	BicD¹ BicD² BicD^R26 capu¹ capu^HK3 egl¹ egl² nos^L7 osk^+t12.75 osk¹ osk² osk³ osk⁴ osk⁵ osk⁶ osk⁷ osk⁸ osk⁹ osk^CE1 osk^CE2 osk^CE3 osk^CE4 ry^+t7.2 spir¹ stau² stau³ tud¹ vas¹ vas³ vls²
Constructs (2)
	P{osk⁺12.75} pP{osk⁺12.75}
Genes (13)
	BicD bcd capu egl fs(1)K10 nos osk ry spir stau tud vas vls