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Reference
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| Citation |
Zhang, K., Chaillet, J.R., Perkins, L.A., Halazonetis, T.D., Perrimon, N. (1990). Drosophila homolog of the mammalian jun oncogene is expressed during embryonic development and activates transcription in
mammalian cells. Proc. Natl. Acad. Sci. USA 87(): 6281--6285. |
| FlyBase ID |
FBrf0052856 |
| Type of publication |
Research paper |
| Offprint Available |
No |
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External Crossreferences
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| PubMed ID |
1696724 |
| PubMed Abstract |
By means of low-stringency cross-species hybridization to Southern DNA blots, human c-jun sequences were used to identify
a unique Drosophila melanogaster locus (Djun). The predicted DJun protein is highly homologous to members of the mammalian
Jun family in both the DNA binding and leucine zipper regions. Djun was mapped by in situ hybridization to position 46E of
the second chromosome. It encodes a 1.7-kilobase transcript constitutively expressed at all developmental stages. Functionally,
Djun in cooperation with mouse c-fos can trans-activate activator protein 1 DNA binding site when introduced into mammalian
cells. Taken together, these data suggest that Djun, much like its mammalian homolog, may activate transcription of genes
involved in regulation of cell growth, differentiation, and development. Furthermore, the identification of Djun allows one
to exploit the genetics of Drosophila to identify genes in signal transduction pathways involving Djun and thus c-jun.
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| Biosis |
90098979 |
| Zoological record |
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Associated Information
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| Text of personal communication |
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Also Published As
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Other Reference Information
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| Secondary IDs |
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| Language of publication |
English |
| Additional language(s) of abstract |
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| ISBN |
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| Place of publication |
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Published In
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| Abbreviation |
Proc. Natl. Acad. Sci. USA |
| Title |
Proceedings of the National Academy of Sciences of the United States of America |
| Authors |
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| Volume range |
1- |
| Year range |
1915- |
| Page range |
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| Publisher |
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| Place of publication |
Washington, DC |
| Language of publication |
English |
| ISBN/ISSN |
0027-8424 |
| CODEN |
PNASA6 |
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Data from Reference
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| Genes (1)
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