Reference Report

Reference
Citation	Adler, P.N., Vinson, C., Park, W.J., Conover, S., Klein, L. (1990). Molecular structure of frizzled, a Drosophila tissue polarity gene. Genetics 126(): 401--416.
FlyBase ID	FBrf0051945
Type of publication	Research paper
Offprint Available	Yes
External Crossreferences
PubMed ID	2174014
PubMed Abstract	The function of the frizzled (fz) locus is required to coordinate the cytoskeletons of pupal epidermal cells so that a parallel array of cuticular hairs and bristles is produced. We report here the molecular cloning and characterization of the fz locus. The locus is very large. Mutations that inactivate the gene are spread over 100 kb of genomic DNA. The major mRNA product of the gene is a 4-kb RNA that is encoded by 5 exons spread over more than 90 kb of genomic DNA. Conceptual translation of this mRNA indicates that it encodes an integral membrane protein that is likely to contain both extracellular and cytoplasmic domains.
Biosis	90134454
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Language of publication	English
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Abbreviation	Genetics
Title	Genetics
Authors
Volume range	1-
Year range	1916-
Page range
Publisher
Place of publication	Austin, TX, etc
Language of publication	English
ISBN/ISSN	0016-6731
CODEN	GENTAE
Data from Reference
Aberrations (5)
	Ab(3L;h)GI1a In(3L)fz³ In(3L)fz^K21 T(2;3)fz²⁷ Tp(3;2)fz^C21
Alleles (15)
	fz¹³ fz²⁰ fz²⁶ fz²⁸ fz³⁰ fz³⁴ fz³⁷ fz³⁸ fz³ fz^CT8D fz^GD4b fz^GE2b fz^GL3a fz^GN6a fz^KB4b
Genes (1)
	fz
Insertions (4)
	?{}fz²⁸ ?{}fz^GD4b ?{}fz^GL3a P{}fz³⁴