|
Reference
|
| Citation |
Peng, X.B., Mount, S.M. (1990). Characterization of enhancer-of-white-apricot in Drosophila melanogaster. Genetics 126(): 1061--1069. |
| FlyBase ID |
FBrf0051917 |
| Type of publication |
Research paper |
| Offprint Available |
Yes |
|
External Crossreferences
|
| PubMed ID |
1706290 |
| PubMed Abstract |
The white-apricot (wa) allele differs from the wild-type white gene by the presence of the retrovirus-like transposable element
copia within the transcription unit. Most RNAs derived from wa have 3' termini within this insertion, and only small amounts
of structurally normal RNA are produced. The activity of wa is reduced in trans by a semidominant mutation in the gene Enhancer-of-white-apricot
(E(wa). Flies that are wa and heterozygous for the enhancer have eyes which are much lighter than the orange-yellow of wa
alone while E(wa) homozygotes have white eyes. This semidominant effect on pigmentation is correlated with a corresponding
decrease in white RNA having wild type structure, and flies homozygous for E(wa) have increased levels of aberrant RNAs. Three
reverant alleles of E(wa) generated by reversion of the dominant enhancer phenotype with gamma radiation are noncomplementing
recessive lethals, with death occurring during the larval stage. The effects on wa eye pigmentation of varying doses of the
original E(wa) allele, the wild type allele, and the revertant alleles suggest that the original E(wa) allele produces a product
that interferes with the activity of the wild type gene and that the revertants are null alleles. We propose that the E(wa)
gene product influences the activity of the downstream copia long terminal repeat in 3' end formation.
|
| Biosis |
91038589 |
| Zoological record |
|
Associated Information
|
| Comments |
|
| Text of personal communication |
|
| Associated files |
|
|
Related Publications
|
|
|
|
Also Published As
|
|
|
|
Other Reference Information
|
| Secondary IDs |
|
| Language of publication |
English |
| Additional language(s) of abstract |
|
| ISBN |
|
| Place of publication |
|
|
Published In
|
| Abbreviation |
Genetics |
| Title |
Genetics |
| Authors |
|
| Volume range |
1- |
| Year range |
1916- |
| Page range |
|
| Publisher |
|
| Place of publication |
Austin, TX, etc |
| Language of publication |
English |
| ISBN/ISSN |
0016-6731 |
| CODEN |
GENTAE |
|
Data from Reference
|
| Aberrations (17)
|
|
|
| Alleles (17)
|
|
|
| Genes (5)
|
|
|
| Insertions (2)
|
|
|
|
Home