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Reference
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| Citation |
Diederich, R.J., Merrill, V.K.L., Pultz, M.A., Kaufman, T.C. (1989). Isolation, structure, and expression of labial, a homeotic gene of the Antennapedia Complex involved in Drosophila head development. Genes Dev. 3(): 399--414. |
| FlyBase ID |
FBrf0049820 |
| Type of publication |
Research paper |
| Offprint Available |
Yes |
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External Crossreferences
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| PubMed ID |
2566560 |
| PubMed Abstract |
The labial (lab) gene of Drosophila melanogaster is necessary for the proper development of the embryonic (larval) and adult
head. We have identified the lab transcription unit within the proximal portion of the Antennapedia Complex (ANT-C) by mapping
the molecular lesions associated with chromosomally rearranged lab alleles. We present its molecular structure, nucleotide
sequence, and temporal pattern of expression. In addition, using antibodies generated against a fusion protein, we show that
in the embryo the lab protein is distributed in neural and epidermal cells of the procephalic lobe; in a discrete loop of
the midgut; and in specific progenitor sensory cells of the clypeolabrum, thoracic segments, and tail region. The regions
of lab expression in the developing cephalon represent nonsegmented domains that are anterior to and largely nonoverlapping
with the domains of expression of the Deformed (Dfd) and proboscipedia (pb) genes, two other homeotic loci of the ANT-C that
also function to direct the development of head structures. Furthermore, lab head expression is associated with the complex
cellular movements of head involution, a process that not only is defective in lab embryos, but the failure of which appears
to be largely responsible for the defects observed in mutant embryos. Finally, we suggest that lab head expression provides
a molecular marker for an intercalary segment, an ancestral segment that has become morphologically indistinct during the
evolution of the insect head.
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| Biosis |
87125528 |
| Zoological record |
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Associated Information
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| Comments |
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| Text of personal communication |
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Related Publications
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Also Published As
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Other Reference Information
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| Secondary IDs |
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| Language of publication |
English |
| Additional language(s) of abstract |
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| ISBN |
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Published In
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| Abbreviation |
Genes Dev. |
| Title |
Genes & Development |
| Authors |
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| Volume range |
1- |
| Year range |
1987- |
| Page range |
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| Publisher |
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| Place of publication |
Cold Spring Harbor, NY |
| Language of publication |
English |
| ISBN/ISSN |
0890-9369 |
| CODEN |
GEDEEP |
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Data from Reference
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| Aberrations (5)
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| Alleles (6)
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| Genes (5)
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