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Reference
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| Citation |
Garber, R.L., Kuroiwa, A., Gehring, W.J. (1983). Genomic and cDNA clones of the homeotic locus Antennapedia in Drosophila. EMBO J. 2(11): 2027--2036.
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| FlyBase ID |
FBrf0039287 |
| Type of publication |
Research paper |
| Offprint Available |
Yes |
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External Crossreferences
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| PubMed ID |
6416827 |
| PubMed Abstract |
Homeotic genes are involved in the control of developmental pathways: dominant mutations at the Antennapedia locus of Drosophila,
for example, lead to replacement of the antennae on the head of the fly by mesothoracic legs. Using a combination of chromosome
walking and jumping, we have cloned a DNA region from Drosophila containing Antennapedia. Five DNA inversion rearrangements
which are associated with the Antennapedia mutant phenotype were localized within a 25-kb region. Genomic DNA sequences from
this area were used as hybridization probes to screen cDNA libraries prepared from Drosophila embryonic and pupal poly(A)+
RNA. A 2.2-kb cDNA sequence (903) was isolated which appears to derive from at least four non-contiguous chromosomal regions
that span 100 kb. It includes the positions of the inversion breakpoints. A second cDNA of 2.9 kb (909) is composed of sequences
from at least three chromosomal regions, two of which are similar or identical to sequences contained in the 903 clone but
the third is derived from genomic DNA within a putative 903 intron. The unusual size and complexity of this locus are discussed.
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| Biosis |
77059163 |
| Zoological record |
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Associated Information
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| Comments |
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| Text of personal communication |
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| Associated files |
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Related Publications
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Also Published As
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Other Reference Information
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| Secondary IDs |
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| Language of publication |
English |
| Additional language(s) of abstract |
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| ISBN |
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| Place of publication |
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Published In
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| Abbreviation |
EMBO J. |
| Title |
The EMBO Journal |
| Authors |
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| Volume range |
1- |
| Year range |
1982- |
| Page range |
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| Publisher |
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| Place of publication |
Oxford |
| Language of publication |
English |
| ISBN/ISSN |
0261-4189 |
| CODEN |
EMJODG |
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Data from Reference
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| Aberrations (12)
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| Alleles (5)
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| Genes (1)
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