Gene Dmel\mir-133

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General Information

Symbol

Dmel\mir-133

Species

D. melanogaster

Name

mir-133

Annotation symbol

CR33574

Feature type

miRNA_gene

FlyBase ID

FBgn0067340

Created / Updated

2005-01-26/2005-01-26

Genomic Location

Chromosome (arm)

Recombination map

Cytogenetic map

38D1-38D1

Sequence location

2L:20,616,673..20,616,694 [+]

Map ( GBrowse )

Summary Information

Automatically generated summary

See sections below for more information

This gene is referred to in FlyBase by the symbol mir-133 (CR33574, FBgn0067340). It has the cytological map location 38D1. Its sequence location is 2L:20616673..20616694. Its molecular function is unknown. The biological processes in which it is involved are not known. No alleles are reported. It has one annotated transcript.

Detailed Mapping Data

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

38C-38D

(Sempere et al., 2003)

Experimentally Determined Recombination Data

Location

Left of (cM)

Right of (cM)

Notes

Molecular Map Data

Gene Order (in direction of increasing cytology)

References

Gene Order (overall orientation not stated)

References

Gene Model & Products

Please see the GBrowse view of Dmel\mir-133 for information on other features

Comments on Gene Model

miRNA support: accession MI0000362 at http://www.sanger.ac.uk/Software/Rfam/mirna/ and FBrf0160938; FBrf0160711; FBrf0162058;

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Associated CDS (aa)

mir-133-RA

FBtr0091551

NR_002240

Additional Transcript Data & Comments

Reported size (kB)

Comments

External Data

Crossreferences

miRBase - the home of microRNA data

•

MI0000362

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kD)

Length (aa)

Theoretical pI

RefSeq ID

GenBank protein

Additional Polypeptide Data & Comments

Reported size (kD)

Comments

External Data

Linkouts

Crossreferences

Sequences Consistent with the Gene Model

DDBJ /
EMBL /
GenBank

DNA sequence

Protein sequence

Name

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Maps to

Does NOT map to

Identified with

Mapped Features & Mutations

Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here

Type

Symbol & Location

Additional Notes

References

External Data

Linkouts

Crossreferences

Expression Data

FlyBase-Curated Data

Transcript and
Protein data

Please see the FlyBase Gene Expression Report for details of gene expression from the literature.

Summary of Transcript Expression

Stage

Tissue/Position

Reference

embryonic stage

(Sempere et al., 2003)

pupal stage

(Sempere et al., 2003)

Marker for

Subcellular Localization

CV Term

Summary of Polypeptide Expression

Stage

Tissue/Position

Reference

Marker for

Subcellular Localization

CV Term

External Data & Images

Linkouts

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0067340

Alleles & Phenotypes

Summary of Allele Phenotypes

Phenotype manifest in

Allele

Classical Alleles ( 0 )

For All Classical Alleles Show

Allele of mir-133	Class	Mutagen	Stocks	Known lesion

Alleles Carried on Transgenic Constructs ( 0 )

For All Alleles Carried on Transgenic Constructs Show

Allele of mir-133	Class	Mutagen	Stocks	Known lesion

Aneuploid Aberrations

Useful deficiency

Df(2L)pr76

Transgenic Constructs & Insertions

Transgenic Constructs

Type of construct

Name

Expression data

Insertions

Type of insertions

Name

Expression data

Related Comments

Please look at the allele reports for the complete phenotype data

Gene Ontology: Function, Process & Cellular Component ( 0 )

Molecular Function

CV term

Evidence

References

Biological Process

CV term

Evidence

References

Cellular Component

CV term

Evidence

References

Sequence Ontology: Class of Gene

miRNA_gene

(Sempere et al., 2003)

nuclear_gene

(Sempere et al., 2003)

Interactions & Pathways

Summary of Genetic Interactions

Interacts with

Please look at the allele data for full details of the genetic interactions

mir-133 allele

Gene

References

External Data

Linkouts

BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions

•

533901

Orthologs

Genome-wide drosophilid orthologs

Curated drosophilid orthologs

Dpse\mir-133

Linkouts

Functional Complementation between Species

Inter-Species Misexpression Data

Produces phenotype in

Produces NO phenotype in

Stocks & Reagents

Stocks Listed in FlyBase ( 0 )

Genomic Clones ( 2 )

cDNA Clones ( 0 )

cDNA Clones, Fully Sequenced

BDGP DGC clones

Other clones

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi & Array Information

Affy Oligo

Linkouts

Antibody Information

Other Information

Discoverer

Etymology

Identification

Position Effect Variegation Data

Relationship to Other Genes

Source for database identity of

Source for database merge of

Additional comments

Comments About Role

Comments About Molecular Function

Other Comments

New annotation (CR33574) in release 4.1 of the genome annotation.

(FlyBase Genome Annotators, 2005)

External Crossreferences & Linkouts

Sequence Crossreferences

RefSeq (Transcripts)

•

NR_002240

Other Crossreferences

miRBase - the home of microRNA data

•

MI0000362

Linkouts

BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions

•

533901

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0067340

FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans

•

FBgn0067340

Synonyms & Secondary IDs ( 3 )

Reported As

Symbol Synonym

CR33574

(FlyBase Genome Annotators, 2005)

miR-133

(Leaman, 2005, Sokol and Ambros, 2005, Nakahara and Carthew, 2004, Lai et al., 2003, Sempere et al., 2003, Stark et al., 2003, Stark et al., 2003, Behura, 2007)

mir-133

Name Synonym

mir-133

Secondary FlyBase IDs

References ( 11 )

Research paper

Rajewsky and Socci, 2004, Dev. Biol. 267(2): 529--535: Computational identification of microRNA targets. [FBrf0174520]
Aravin et al., 2003, Dev. Cell 5(2): 337--350: The small RNA profile during Drosophila melanogaster development. [FBrf0162058]
Lai et al., 2003, GenomeBiol. 4(7): R42: Computational identification of Drosophila microRNA genes. [FBrf0160711]
Sempere et al., 2003, Dev. Biol. 259(1): 9--18: Temporal regulation of microRNA expression in Drosophila melanogaster mediated by hormonal signals and Broad-Complex gene activity. [FBrf0160938]

Supplementary material

Leaman, 2005, Cell 121(7):: [title not yet available] [FBrf0191779]
Stark et al., 2003, PLoS Biol. 1(3): DOI:10.1371/journal.pbio.0000060.sd001: Dataset S1. Complete Lists. [FBrf0173091]
Stark et al., 2003, PLoS Biol. 1(3): DOI:10.1371/journal.pbio.0000060.sd002: Dataset S2. Top 100 List. [FBrf0173092]

Review

Behura, 2007, Insect Biochem. Molec. Biol. 37(1): 3--9: Insect microRNAs: Structure, function and evolution. [FBrf0194885]
Nakahara and Carthew, 2004, Curr. Opin. Cell Biol. 16: 127--133: Expanding roles for miRNAs and siRNAs in cell regulation. [FBrf0179907]

Abstract

Sokol and Ambros, 2005, A. Dros. Res. Conf. 46: 73: Functional Analysis of microRNA-1. [FBrf0183493]

FlyBase analysis

FlyBase Genome Annotators, 2005, Changes affecting gene model number or type in release 4.1 of the annotated D.melanogaster genome.: Changes affecting gene model number or type in release 4.1 of the annotated D.melanogaster genome. [FBrf0179613]