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Gene Dmel\ban

General Information
Symbol	Dmel\ban	Species	D. melanogaster
Name	bantam	Annotation symbol	CR33559
Feature type	miRNA_gene	FlyBase ID	FBgn0064191
Created / Updated	2005-01-26/2005-01-26
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	61C7-61C7	Sequence location	3L:642,259..642,281 [+]
Map ( GBrowse )	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene bantam is referred to in FlyBase by the symbol ban (CR33559, FBgn0064191). It has the cytological map location 61C7. Its sequence location is 3L:642259..642281. Its molecular function is described as mRNA 3'-UTR binding. It is involved in the biological processes described with 14 unique terms, many of which group under: regulation of biological process; cell proliferation; positive regulation of biological process; regulation of apoptosis; gene silencing by miRNA; negative regulation of cellular biosynthetic process; regulation of developmental process; regulation of growth; programmed cell death; regulation of multicellular organism growth; regulation of metabolic process. 13 alleles are reported. The phenotypes of these alleles are annotated with 12 unique terms, many of which group under: peripheral nervous system; nervous system; organ system; adult segment; adult mesothoracic segment; adult; thoracic segment; tormogen cell; cell cycle; larval nervous system. It has one annotated transcript.
External Summaries
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 61C7-61C8   Left limit from in situ hybridisation (FBrf0128367) Right limit from in situ hybridisation (FBrf0128367)
Experimentally Determined Cytological Location
Cytogenetic map Notes References 61C7-61C8 (determined by in situ hybridisation)   (Abdelilah-Seyfried et al., 2000)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Molecular Map Data
Gene Order (in direction of increasing cytology) References Gene Order (overall orientation not stated) References
Gene Model & Products
Please see the GBrowse view of Dmel\ban for information on other features
Comments on Gene Model
	miRNA support: accession MI0000387 at http://www.sanger.ac.uk/Software/Rfam/mirna/ and FBrf0158764; FBrf0160711; FBrf0162058;
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) ban-RA FBtr0091536  NR_002268   23
Additional Transcript Data & Comments
Reported size (kB)	.021 (northern blot, sequence analysis) (Brennecke et al., 2003)
Comments
External Data
Crossreferences	miRBase - the home of microRNA data • MI0000387
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kD) Length (aa) Theoretical pI RefSeq ID GenBank protein
Additional Polypeptide Data & Comments
Reported size (kD)
Comments
External Data
Linkouts
Crossreferences
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AJ550546   AQ026239   AQ073819   CQ877205   CQ877206   CQ877207   CQ877208   CQ877209   CQ877210
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL
Maps to
Does NOT map to
Identified with
Mapped Features & Mutations
Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
FlyBase-Curated Data
Transcript and Protein data	Please see the FlyBase Gene Expression Report for details of gene expression from the literature.
Summary of Transcript Expression
Stage Tissue/Position Reference  adult stage-embryonic stage   (Brennecke et al., 2003)  larval stage  brain (Brennecke et al., 2003)  larval stage  dorsal mesothoracic disc (Brennecke et al., 2003)
Marker for
Subcellular Localization
CV Term
Summary of Polypeptide Expression
Stage Tissue/Position Reference
Marker for
Subcellular Localization
CV Term
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0064191
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable (with Df(3L)banΔ1) banL1170a viable (with Df(3L)banΔ1), with Scer\GAL4[-]: banEP3208 banEP3622 banEPg30491 viable, with Scer\GAL4[-]: banEP3622 banEPg30491 lethal | pupal stage, with Df(3L)banΔ1, Scer\GAL4unspecified banA.Scer\UAS banD.Scer\UAS.T:Avic\GFP-EGFP Other Phenotypes Allele visible, with Scer\GAL4sca-537.4 banEP3208 visible, with Scer\GAL4Bx-MS1096 banEP3622 banUY1079 banUY1678 banUY3207 banUY789 visible, with Scer\GAL4en-e16E banEP3622 banUY1079 banUY1678 banUY3207 banUY789 visible, with Scer\GAL4ap-md544 banEP3622 visible, with Scer\GAL4GMR.PF banEP3622 banUY3207 small body (with Df(3L)emc), with Scer\GAL4[-]: banEP3622 banUY3207 small body (with Df(3L)banΔ1) banL1170a small body (with Df(3L)banΔ1), with Scer\GAL4[-]: banEP3208 banEP3622 banEPg30491 banUY3207 small body (with banEP3622), with Scer\GAL4[-]: banUY3207 small body (with banUY3207), with Scer\GAL4[-]: banEP3622 small body, with Scer\GAL4[-]: banEP3622 banEPg30491 banUY3207 reduced cell number (with Df(3L)banΔ1) banL1170a reduced cell number (with Df(3L)banΔ1), with Scer\GAL4[-]: banEP3622 banEPg30491 banUY3207 reduced cell number (with banEP3622), with Scer\GAL4[-]: banUY3207 reduced cell number (with banUY3207), with Scer\GAL4[-]: banEP3622 reduced cell number | cell non-autonomous, with Scer\GAL4en-e16E banEP3622 reduced cell number, with Scer\GAL4[-]: banEP3622 banUY3207 reduced cell size, with Scer\GAL4en-e16E banEP3622 reduced cell size, with Scer\GAL4ap-md544 banEP3622 increased cell number | cell autonomous, with Scer\GAL4en-e16E banEP3622 increased cell size | somatic clone, with Scer\GAL4Act5C.PP banEP3622 cell death decrease, with Scer\GAL4GMR.PF banEP3622 neuroanatomy defective | larval stage, with Scer\GAL4elav-C155 banEP3208 Sterility Allele female sterile (with Df(3L)banΔ1) banL1170a female sterile (with Df(3L)banΔ1), with Scer\GAL4[-]: banEP3208 female sterile | partially (with Df(3L)banΔ1), with Scer\GAL4[-]: banEP3622 banEPg30491 female sterile | partially, with Scer\GAL4[-]: banEP3622 banEPg30491 Phenotype manifest in Allele wing | posterior, with Scer\GAL4en-e16E banA.Scer\UAS banC.Scer\UAS.T:Avic\GFP-EGFP banD.Scer\UAS.T:Avic\GFP-EGFP larval segment, with Scer\GAL4en-e16E banA.Scer\UAS banC.Scer\UAS.T:Avic\GFP-EGFP banD.Scer\UAS.T:Avic\GFP-EGFP interommatidial bristle | ectopic, with Scer\GAL4GMR.PF banA.Scer\UAS cell cycle, with Scer\GAL4ptc-559.1 banC.Scer\UAS.T:Avic\GFP-EGFP wing, with Scer\GAL4en-e16E banEP3208 banEP3622 banEPg30491 banUY1079 banUY1678 banUY3207 banUY789 scutellar bristle | ectopic, with Scer\GAL4sca-537.4 banEP3208 tormogen cell, with Scer\GAL4sca-537.4 banEP3208 anterior fascicle & synapse, with Scer\GAL4elav-C155 banEP3208 anterior fascicle, with Scer\GAL4elav-C155 banEP3208 wing | posterior compartment, with Scer\GAL4en-e16E banEP3622 mesothoracic tergum, with Scer\GAL4ap-md544 banEP3622 microchaeta, with Scer\GAL4ap-md544 banEP3622 eye, with Scer\GAL4GMR.PF banEP3622 banUY3207 interommatidial bristle | supernumerary, with Scer\GAL4GMR.PF banEP3622 pigment cell | supernumerary, with Scer\GAL4GMR.PF banEP3622 wing, with Scer\GAL4Bx-MS1096 banEP3622 banUY1079 banUY1678 banUY3207 banUY789 wing (with Df(3L)banΔ1), with Scer\GAL4[-]: banEP3622 banUY3207 wing, with Scer\GAL4[-]: banEP3622 banUY3207 wing (with banUY3207), with Scer\GAL4[-]: banEP3622 wing (with Df(3L)emc), with Scer\GAL4[-]: banEP3622 banUY3207 ommatidium, with Scer\GAL4GMR.PF banUY3207 wing (with banEP3622), with Scer\GAL4[-]: banUY3207
Classical Alleles ( 8 )
For All Classical Alleles Show
Allele of ban Class Mutagen Stocks Known lesion banEP3208 P-element activity 1 -- banEP3622 hypomorph P-element activity 1 Yes banEPg30491 hypomorph P-element activity 0 Yes banL1170a P-element activity 1 -- banUY1079 P-element activity 0 -- banUY1678 P-element activity 0 -- banUY3207 P-element activity 0 -- banUY789 P-element activity 0 --
Alleles Carried on Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Allele of ban Class Mutagen Stocks Known lesion ban+t6.7 in vitro construct | genomic fragment 0 Yes ban+t9.6 in vitro construct | genomic fragment 0 Yes banA.Scer\UAS in vitro construct | regulatory fusion 0 Yes banC.Scer\UAS.T:Avic\GFP-EGFP in vitro construct | other 0 Yes banD.Scer\UAS.T:Avic\GFP-EGFP in vitro construct | other 0 Yes
Aneuploid Aberrations
Useful deficiency	Df(3L)Ar11
Disrupted in	Df(3L)banΔ1 (Hipfner et al., 2002) Df(3L)emc (Raisin et al., 2003)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data characterization construct P{Tub-EGFP.ban} NA P{UAS-B} NA P{ban+t6.7} NA P{ban+t9.6} NA UAS construct P{UAS-A} NA P{UAS-C} NA P{UAS-D} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EPg}banEPg30491a NA P{EPg}banEPg30491b NA P{EP}banEP3208 NA P{EP}banEP3622a NA P{EP}banEP3622b NA P{Mae-UAS.6.11}banUY1079 NA P{Mae-UAS.6.11}banUY1678 NA P{Mae-UAS.6.11}banUY3207 NA P{Mae-UAS.6.11}banUY789 NA insertion of enhancer trap P{lArB}L61C No P{lacW}banL1170a No
Related Comments
	Please look at the allele reports for the complete phenotype data
Gene Ontology: Function, Process & Cellular Component ( 15 )
Molecular Function
CV term Evidence References
mRNA 3'-UTR binding traceable author statement (He and Hannon, 2004) traceable author statement (Bergmann and Lane, 2003)
Biological Process
CV term Evidence References
anti-apoptosis inferred from genetic interaction with FLYBASE:W; FB:FBgn0003997 AND inferred from mutant phenotype (Brennecke et al., 2003) non-traceable author statement (Ambros, 2003) traceable author statement (Bergmann and Lane, 2003) traceable author statement (Xu et al., 2004)
cell growth traceable author statement (Xu et al., 2004)
cell proliferation inferred from mutant phenotype (Brennecke et al., 2003) inferred from mutant phenotype (Thompson and Cohen, 2006)
eye development inferred from physical interaction with FLYBASE:hpo; FB:FBgn0034453 (Nolo et al., 2006)
gene silencing by miRNA inferred from mutant phenotype inferred from direct assay (Orom et al., 2006)
gene silencing by miRNA, negative regulation of translation traceable author statement (Gesellchen and Boutros, 2004) traceable author statement (Nakahara and Carthew, 2004)
negative regulation of translation traceable author statement (He and Hannon, 2004)
positive regulation of cell proliferation inferred from mutant phenotype (Raisin et al., 2003) traceable author statement (Ambros, 2003) traceable author statement (Bergmann and Lane, 2003)
positive regulation of growth traceable author statement (Bergmann and Lane, 2003)
positive regulation of multicellular organism growth inferred from mutant phenotype (Raisin et al., 2003)
regulation of apoptosis inferred from physical interaction with FLYBASE:hpo; FB:FBgn0034453 (Nolo et al., 2006)
regulation of cell proliferation inferred from physical interaction with FLYBASE:hpo; FB:FBgn0034453 (Nolo et al., 2006)
regulation of growth inferred from physical interaction with FLYBASE:yki; FB:FBgn0034970 (Nolo et al., 2006)
regulation of multicellular organism growth inferred from mutant phenotype (Hipfner et al., 2002)
Cellular Component
CV term Evidence References
Sequence Ontology: Class of Gene
	miRNA_gene (Brennecke et al., 2003) nuclear_gene (Brennecke et al., 2003)
Interactions & Pathways
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions ban allele Gene References banEP3622 rpr (Brennecke et al., 2003) W (Brennecke et al., 2003) ex (Hipfner et al., 2002) Dp (Brennecke et al., 2003) banUY1079 Pi3K92E (Raisin et al., 2003) banUY1678 Pi3K92E (Raisin et al., 2003) banUY3207 Pi3K92E (Raisin et al., 2003) banUY789 Pi3K92E (Raisin et al., 2003) unspecified W (Mueller et al., 2005) H (Mueller et al., 2005) E2f (Brennecke et al., 2003) p53 (Mueller et al., 2005) hpo (Nolo et al., 2006) CycE (Nolo et al., 2006)
External Data
Linkouts	BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions • 534146
Orthologs
Genome-wide drosophilid orthologs
Curated drosophilid orthologs	Dpse\ban
Linkouts
Functional Complementation between Species
Inter-Species Misexpression Data
Produces phenotype in
Produces NO phenotype in
Stocks & Reagents
Stocks Listed in FlyBase ( 3 )
Szeged	- P{EP}banEP3208 - P{EP}CG17667EP3622 banEP3622
Bloomington	10154 y1 w1118; P{lacW}banL1170a, l(3)L1170bL1170b/TM3, Ser1
Genomic Clones ( 2 )
	BACR18B21 BACR04C03
cDNA Clones ( 0 )
cDNA Clones, Fully Sequenced
BDGP DGC clones
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones
RNAi & Array Information
Affy Oligo
Linkouts
Antibody Information
Other Information
Discoverer
Etymology
	Etymology: gene is named "bantam" after the mutant phenotype; mutant flies are smaller than normal. (Hipfner et al., 2002)
Identification
Position Effect Variegation Data
Relationship to Other Genes
Source for database identity of	Source for identity of: ban EP3208 Evidence suggests that the @P{EP}EP3219<up>EP3219</up>@ insertion is probably not an allele of "ban" but instead affects a genetically separable locus; the decrease in wing size seen in @EP3219<up>EP3219</up>@/@Df(3L)ban<up>Δ1</up>@ flies is due primarily to a reduction in cell size rather than cell number, in contrast to @ban<up>L1170a</up>@/@Df(3L)ban<up>Δ1</up>@, @ban<up>EP3622</up>@/@Df(3L)ban<up>Δ1</up>@ or @ban<up>EPg30491</up>@/@Df(3L)ban<up>Δ1</up>@ flies, where the decrease in wing size is due to a reduction in the number of cells. In addition, @EP3219<up>EP3219</up>@ combined with @ban<up>L1170a</up>@, @ban<up>EPg30491</up>@ or @ban<up>EP3622</up>@ has little or no effect on growth. (Hipfner et al., 2002)
Source for database merge of
Additional comments	"BEST:RE64518" does not encode "ban" function. (Brennecke et al., 2003)
Comments About Role
	ban microRNA simultaneously stimulates cell proliferating and prevent apoptosis. (Brennecke et al., 2003) ban mutant clones grow poorly due to a reduced rate of cell proliferation. (Thompson and Cohen, 2006) ban acts downstream of yki in the hpo pathway. (Thompson and Cohen, 2006) ban suppresses W expression. (Nolo et al., 2006)
Comments About Molecular Function
	ban is a target of the hpo signalling pathway. (Nolo et al., 2006)
Other Comments
	New annotation (CR33559) in release 4.1 of the genome annotation. (FlyBase Genome Annotators, 2005)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NR_002268 DDBJ / EMBL / GenBank • AJ550546 AQ026239 AQ073819 CQ877205 CQ877206 CQ877207 CQ877208 CQ877209 CQ877210
Other Crossreferences
	miRBase - the home of microRNA data • MI0000387
Linkouts
	BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions • 534146 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0064191 FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0064191 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /sturtevant/bantam1.htm
Synonyms & Secondary IDs ( 8 )
Reported As
Symbol Synonym	ban (Thompson and Cohen, 2006, Meyer et al., 2006) cot (Raisin et al., 2003) CR33559 (FlyBase Genome Annotators, 2005) EP3208 (Abdelilah-Seyfried et al., 2000, ) unnamed (Kraut et al., 2001)
Name Synonym	Bantam (He and Hannon, 2004) bantam (Hipfner et al., 2002, Reynolds, 2007, Thompson and Cohen, 2006, Vagin et al., 2006, Nolo et al., 2006, Orom et al., 2006, Stark et al., 2005, Shcherbata et al., 2007, Neumueller et al., 2007, Garcia et al., 2007, Nurminsky, 2007, Förstemann et al., 2007, Shcherbata et al., 2008, Reynolds et al., 2008) clochette (Raisin et al., 2003)
Secondary FlyBase IDs
	FBgn0043352
References ( 63 )
Generate a list of	All references relating to this gene ( 63 )
List References by type	Research paper  ( 25 ) Supplementary material  ( 2 ) Review  ( 23 ) Abstract  ( 6 ) FlyBase analysis  ( 1 ) Conference report  ( 3 ) Patent  ( 1 ) Computer file  ( 2 )
Recent research papers ( 6 )
	Förstemann et al., 2007, Cell 130(2): 287--297 Drosophila microRNAs are sorted into functionally distinct argonaute complexes after production by Dicer-1. [FBrf0200521] Meyer et al., 2006, PLoS Gen. 2(8): Overlapping functions of argonaute proteins in patterning and morphogenesis of Drosophila embryos. [FBrf0194224] Nolo et al., 2006, Curr. Biol. 16(19): 1895--1904 The bantam microRNA is a target of the hippo tumor-suppressor pathway. [FBrf0194704] Orom et al., 2006, Gene 372: 137--141 LNA-modified oligonucleotides mediate specific inhibition of microRNA function. [FBrf0190503] Thompson and Cohen, 2006, Cell 126(4): 767--774 The hippo pathway regulates the bantam microRNA to control cell proliferation and apoptosis in Drosophila. [FBrf0193861] Vagin et al., 2006, Science 313(5785): 320--324 A distinct small RNA pathway silences selfish genetic elements in the germline. [FBrf0194520] Show all research papers ...
Recent reviews ( 2 )
	Behura, 2007, Insect Biochem. Molec. Biol. 37(1): 3--9 Insect microRNAs: Structure, function and evolution. [FBrf0194885] Vidal and Cagan, 2006, Curr. Opin. Genet. Dev. 16(1): 10--16 Drosophila models for cancer research. [FBrf0190065] Show all reviews ...