HomeGene Dmel\Mbs
| General Information | |||
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| Symbol | Dmel\Mbs | Species | D. melanogaster |
| Name | Myosin binding subunit | Annotation symbol | CG32156 |
| Feature type | protein_coding_gene | FlyBase ID | FBgn0005536 |
| Created / Updated | 2003-12-01/2003-12-01 | ||
| Genomic Location | |||
| Chromosome (arm) | 3L | Recombination map | |
| Cytogenetic map | 72D1-72D1 | Sequence location | 3L:16,045,068..16,075,130 [+] |
| Map ( GBrowse ) | 
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Summary Information
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Automatically generated summary
See sections below for more information | The gene Myosin binding subunit is referred to in FlyBase by the symbol Mbs (CG32156, FBgn0005536). It has the cytological map location 72D1. Its sequence location is 3L:16045068..16075130. Its molecular function is described as: myosin phosphatase activity; myosin binding. It is involved in the biological processes: dorsal closure; regulation of compound eye photoreceptor development; imaginal disc-derived wing hair organization and biogenesis; oogenesis; epidermis development. 35 alleles are reported. The phenotypes of these alleles are annotated with 12 unique terms, many of which group under: organ system; anatomical structure; adult segment; portion of tissue; integumentary system; adult mesothoracic segment; adult; egg; wing hair; imaginal precursor; peripheral nervous system. It has 6 annotated transcripts and 6 annotated polypeptides. | ||
| External Summaries | |||
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Detailed Mapping Data
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| FlyBase Computed Cytological Location | |||
Cytogenetic map Evidence for location 72D1-72D1
Limits computationally determined from genome sequence between P{lacW}thj5C8&P{PZ}Mbs03802 and P{lacW}SsRβs1939
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| Experimentally Determined Cytological Location | |||
Cytogenetic map Notes References 72D1-72D2 (determined by in situ hybridisation)
72C-72C (determined by in situ hybridisation)
72C-72C (determined by in situ hybridisation)
72D1-72D2 (determined by in situ hybridisation)
72D1-72D2 | |||
| Experimentally Determined Recombination Data | |||
| Location | |||
| Left of (cM) | |||
| Right of (cM) | |||
| Notes | |||
| Molecular Map Data | |||
Gene Order (in direction of increasing cytology)
References Gene Order (overall orientation not stated) References | |||
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Gene Model & Products
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Please see the
GBrowse view of
Dmel\Mbs
for information on other features
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| Comments on Gene Model | |||
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Transcript Data
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| Annotated Transcripts | |||
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) FBtr0112850
2405
367 FBtr0112851
3775
795 FBtr0112852
4161
925 | |||
| Additional Transcript Data & Comments | |||
| Reported size (kB) | |||
| Comments | |||
| External Data | |||
| Crossreferences | |||
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Polypeptide Data
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| Annotated Polypeptides | |||
Name FlyBase ID
Predicted MW (kD)
Length (aa)
Theoretical pI
RefSeq ID
GenBank protein
FBpp0111763
39.3
367
10.35
FBpp0111764
87.3
795
6.39
FBpp0111765
101.2
925
7.05
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| Additional Polypeptide Data & Comments | |||
| Reported size (kD) | |||
| Comments | |||
| External Data | |||
| Linkouts | PANTHER
- Protein classification by function, families, and pathways
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| Crossreferences | InterPro
domains - A database of protein families, domains, and functional sites
• Ankyrin (IPR002110)
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Sequences Consistent with the Gene Model
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| DDBJ
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EMBL / GenBank | DNA sequence Protein sequence Name | ||
| UniProtKB/Swiss-Prot | |||
| UniProtKB/TrEMBL | |||
| Maps to | |||
| Does NOT map to | |||
| Identified with | |||
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Mapped Features & Mutations
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Please see
GBrowse
or insertion reports for information on insertions of transgenic
constructs and features not listed here
Type Symbol & Location Additional Notes References point mutation Mbs[T541] 3L:16,046,470..16,046,471 comment=G to A nucleotide change at the second or third position of the Trp codon leads to a nonsense mutation. (exact site of mutation unspecified). Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change. evidence=experimental reported_pr_change=W22@ point mutation Mbs[T666] 3L:16,055,751..16,055,751 comment=Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change. position of mutation on reference sequence inferred by FlyBase curator based on author statement. evidence=experimental na_change=C16055751T pr_change=Q238|Mbs-PC,Q238|Mbs-PA,Q238|Mbs-PG,Q238|M bs-PH reported_pr_change=Q239@ point mutation Mbs[T791] 3L:16,055,767..16,055,768 comment=G to A nucleotide change at the second or third position of the Trp codon leads to a nonsense mutation. (exact site of mutation unspecified). Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change. evidence=experimental reported_pr_change=W243@ | |||
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External Data
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| Linkouts | DEDB
- Drosophila exon database: splicing graphs
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| Crossreferences | |||
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Expression Data
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| FlyBase-Curated Data | |||
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Transcript and Protein data | Please see the FlyBase Gene Expression Report for details of gene expression from the literature. | ||
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Summary of Transcript Expression
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Stage Tissue/Position
Reference
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| Marker for | |||
| Subcellular Localization | |||
| CV Term | |||
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Summary of Polypeptide Expression
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Stage Tissue/Position
Reference
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| Marker for | |||
| Subcellular Localization | |||
| CV Term | |||
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Microarray Data
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Developmental timecourse, Costello et al., 2008 (Original data from Arbeitman et al., 2002) 
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External Data & Images
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| Linkouts | FLIGHT
- Cell culture data for RNAi and other high-throughput technologies
FlyAtlas
- Adult expression by tissue, using Affymetrix Dros2 array
GEO (NCBI)
- Gene expression data: microarray and other high-throughput technologies
FlyExpress
- Embryonic expression images (BDGP data)
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Alleles & Phenotypes
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Summary of Allele Phenotypes
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Lethality Allele viable, with Scer\GAL4[-]: Other Phenotypes Allele Sterility Allele Phenotype manifest in Allele | |||
Stage(s)
13-16