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Gene Dmel\CG33087

General Information
Symbol	Dmel\CG33087	Species	D. melanogaster
Name	CG33087	Annotation symbol	CG33087
Feature type	protein_coding_gene	FlyBase ID	FBgn0053087
Created / Updated	2003-12-02/2003-12-02
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	44C1-44C2	Sequence location	2R:4,094,023..4,113,243 [+]
Map ( GBrowse )	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol CG33087 (FBgn0053087). It has the cytological map location 44C1-44C2. Its sequence location is 2R:4094023..4113243. Its molecular function is described as: low-density lipoprotein receptor activity; ATP binding; ATPase activity; calcium ion binding. The biological processes in which it is involved are not known. 6 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 44C1-44C2   Limits computationally determined from genome sequence between P{lacW}Rs1k09514&P{lacW}l(2)k03110k03110 and P{lacW}Vps25k08904&P{lacW}ptck02507
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Molecular Map Data
Gene Order (in direction of increasing cytology) References Gene Order (overall orientation not stated) References
Gene Model & Products
Please see the GBrowse view of Dmel\CG33087 for information on other features
Comments on Gene Model
	Intron-exon structure based upon gene prediction data. DGC clone appears problematic (GM28973): incomplete CDS (very short relative to full length of predicted transcript).
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG33087-RC FBtr0088791  NM_176104   14423   4699
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kD) Length (aa) Theoretical pI RefSeq ID GenBank protein CG33087-PC   FBpp0087868   524.9   4699   4.79     NP_788284   AAF59114
Additional Polypeptide Data & Comments
Reported size (kD)
Comments
External Data
Linkouts	PANTHER - Protein classification by function, families, and pathways • FBgn0053087
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Low-density lipoprotein receptor, YWTD repeat (IPR000033) Aspartic acid and asparagine hydroxylation site (IPR000152) EGF-like, type 3 (IPR000742) EGF-like calcium-binding (IPR001881) Low density lipoprotein-receptor, class A, cysteine-rich (IPR002172) ABC transporter-like (IPR003439) EGF-like (IPR006209) EGF (IPR006210) EGF-like region, conserved site (IPR013032) EGF calcium-binding (IPR013091) EGF, extracellular (IPR013111) Six-bladed beta-propeller, TolB-like (IPR011042) Follistatin-like, N-terminal (IPR003645)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE003838 AAF59114   BG638671   BI354938   CL528067   CZ486852   EC204957
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	A1Z7C4
Maps to
Does NOT map to
Identified with	GM28973 (BDGP Project Members, 2000-)
Mapped Features & Mutations
Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here Type Symbol & Location Additional Notes References
External Data
Linkouts	DEDB - Drosophila exon database: splicing graphs • 13412
Crossreferences
Expression Data
FlyBase-Curated Data
Transcript and Protein data	Please see the FlyBase Gene Expression Report for details of gene expression from the literature.
Summary of Transcript Expression
Stage Tissue/Position Reference
Marker for
Subcellular Localization
CV Term
Summary of Polypeptide Expression
Stage Tissue/Position Reference
Marker for
Subcellular Localization
CV Term
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0053087 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • FBgn0053087 GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies • FBgn0053087
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable CG33087EY07878 Sterility Allele fertile CG33087EY07878 Phenotype manifest in Allele
Classical Alleles ( 2 )
For All Classical Alleles Show
Allele of CG33087 Class Mutagen Stocks Known lesion CG33087EY07878 P-element activity 1 -- CG33087f04317 piggyBac transposase 1 --
Alleles Carried on Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG33087 Class Mutagen Stocks Known lesion CG33087GD134 in vitro construct | RNAi in vitro construct | regulatory fusion 1 Yes CG33087GD14394 in vitro construct | RNAi in vitro construct | regulatory fusion 2 Yes CG33087GD2630 in vitro construct | RNAi in vitro construct | regulatory fusion 1 Yes CG33087GD5740 in vitro construct | RNAi in vitro construct | regulatory fusion 2 Yes
Aneuploid Aberrations
Useful deficiency	Df(2R)NCX10
Disrupted in	Df(2R)Exel6056 (Ryder, 2004.4.26) Df(2R)Exel6057 (Ryder, 2004.4.26) Df(2R)Exel7095 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD134} NA P{GD14394} NA P{GD2630} NA P{GD5740} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions PBac{WH}CG33087f04317 NA insertion of mobile activating element P{EPgy2}CG33087EY07878 NA
Related Comments
	Please look at the allele reports for the complete phenotype data
Gene Ontology: Function, Process & Cellular Component ( 5 )
Molecular Function
CV term Evidence References
ATP binding inferred from electronic annotation with InterPro:IPR003439 (FlyBase Curators et al., 2004-)
ATPase activity inferred from electronic annotation with InterPro:IPR003439 (FlyBase Curators et al., 2004-)
calcium ion binding inferred from electronic annotation with InterPro:IPR001881 (FlyBase Curators et al., 2004-)
low-density lipoprotein receptor activity inferred from sequence or structural similarity with UniProtKB:O75097 (FlyBase, 1992-)
Biological Process
CV term Evidence References
Cellular Component
CV term Evidence References
membrane inferred from electronic annotation with InterPro:IPR000033 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	protein_coding_gene   nuclear_gene
Interactions & Pathways
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG33087 allele Gene References
External Data
Linkouts	BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions • 61653 Drosophila PIMRider - The Drosophila Protein Interaction map • 521297
Orthologs
Genome-wide drosophilid orthologs	Dana\GF12345 Dere\GG23343 Dgri\GH21081 Dmoj\GI18681 Dper\GL11210 Dpse\GA24641 Dsec\GM21016 Dsim\GD15368 Dvir\GJ21697 Dwil\GK15819 Dyak\GE19184
Curated drosophilid orthologs	Dpse\GA17269
Linkouts	InParanoid orthologs - Eukaryotic orthologs • ENSANGP00000011153 Anopheles gambiae (Ensembl) ENSBTAP00000017556 Bos taurus (Ensembl) ENSCAFP00000000266 Canis familiaris (Ensembl) NEWSINFRUP00000181647 Takifugu rubripes (Ensembl) ENSP00000243077 Homo sapiens (Ensembl) ENSMMUP00000012945 Macaca mulatta (Ensembl) ENSMODP00000003507 Monodelphis domestica (Ensembl) ENSPTRP00000021397 Pan troglodytes (Ensembl) ENSRNOP00000034210 Rattus norvegicus (Ensembl) ENSXETP00000023897 Xenopus tropicalis (Ensembl) WBGene00033059 Caenorhabditis briggsae (Wormbase) MGI:96828 Mus musculus (Informatics)
Functional Complementation between Species
Inter-Species Misexpression Data
Produces phenotype in
Produces NO phenotype in
Stocks & Reagents
Stocks Listed in FlyBase ( 8 )
Harvard	- PBac{WH}CG33087f04317
VDRC	v8397 w1118; P{GD2630}v8397 v13912 w1118; P{GD5740}v13912 v13913 w1118; P{GD5740}v13913 v39215 w1118; P{GD14394}v39215 v3710 w1118; P{GD134}v3710/CyO v39216 w1118; P{GD14394}v39216/CyO
Bloomington	16864 y1 w67c23; P{EPgy2}CG33087EY07878
Genomic Clones ( 1 )
	BACR09N11
cDNA Clones ( 1 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	LD32611
Other clones
RNAi & Array Information
Affy Oligo
Linkouts	DRSC - RNAi screening (Harvard): high-throughput cell culture data and design • FBgn0053087 GenomeRNAi - RNAi phenotypes (Heidelberg): high-throughput cell culture data • FBgn0053087
Antibody Information
Other Information
Discoverer
Etymology
Identification
Position Effect Variegation Data
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: CG30368 CG8706 (FlyBase Genome Annotators, 2002-2003)
Additional comments	FlyBase curator comment: Correspondence with author Parra-Peralbo revealed that 'lrp1' = 'CG33087'. (Parra-Peralbo and Culi, 2007)
Comments About Role
Comments About Molecular Function
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_176104 RefSeq (Proteins) • NP_788284 DDBJ / EMBL / GenBank • AE003838 AAF59114 BI354938 CL528067 CZ486852 UniProtKB/TrEMBL • A1Z7C4
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Low-density lipoprotein receptor, YWTD repeat (IPR000033) Aspartic acid and asparagine hydroxylation site (IPR000152) EGF-like, type 3 (IPR000742) EGF-like calcium-binding (IPR001881) Low density lipoprotein-receptor, class A, cysteine-rich (IPR002172) ABC transporter-like (IPR003439) EGF-like (IPR006209) EGF (IPR006210) EGF-like region, conserved site (IPR013032) EGF calcium-binding (IPR013091) EGF, extracellular (IPR013111) Six-bladed beta-propeller, TolB-like (IPR011042) Follistatin-like, N-terminal (IPR003645)
Linkouts
	BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions • 61653 DEDB - Drosophila exon database: splicing graphs • 13412 DRSC - RNAi screening (Harvard): high-throughput cell culture data and design • FBgn0053087 Drosophila PIMRider - The Drosophila Protein Interaction map • 521297 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0053087 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • FBgn0053087 FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0053087 GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies • FBgn0053087 GenomeRNAi - RNAi phenotypes (Heidelberg): high-throughput cell culture data • FBgn0053087 InParanoid orthologs - Eukaryotic orthologs • ENSANGP00000011153 Anopheles gambiae (Ensembl) ENSBTAP00000017556 Bos taurus (Ensembl) ENSCAFP00000000266 Canis familiaris (Ensembl) NEWSINFRUP00000181647 Takifugu rubripes (Ensembl) ENSP00000243077 Homo sapiens (Ensembl) ENSMMUP00000012945 Macaca mulatta (Ensembl) ENSMODP00000003507 Monodelphis domestica (Ensembl) ENSPTRP00000021397 Pan troglodytes (Ensembl) ENSRNOP00000034210 Rattus norvegicus (Ensembl) ENSXETP00000023897 Xenopus tropicalis (Ensembl) WBGene00033059 Caenorhabditis briggsae (Wormbase) MGI:96828 Mus musculus (Informatics) PANTHER - Protein classification by function, families, and pathways • FBgn0053087
Synonyms & Secondary IDs ( 9 )
Reported As
Symbol Synonym	CG8706 (Bolshakov et al., 2002, Mount, 2001.8.14, ) CG30368   CG33087   CT9297 (Hynes and Zhao, 2000) LDLR (Soukup and Gubb, 2007) LRP1 (Parra-Peralbo and Culi, 2007) lrp1 (Parra-Peralbo and Culi, 2007)
Name Synonym	CG33087   LDL-receptor-related protein 1 (Parra-Peralbo and Culi, 2007) LDLR-like (Hynes and Zhao, 2000)
Secondary FlyBase IDs
	FBgn0033276 FBgn0050368
References ( 15 )
Research paper	Bolshakov et al., 2002, Genome Res. 12(1): 57--66 A comparative genomic analysis of two distant Diptera, the fruit fly, Drosophila melanogaster, and the malaria mosquito, Anopheles gambiae. [FBrf0141561]
Supplementary material	Giot et al., 2003, Science 302(5651): Tables S1 to S7. [FBrf0166452] Hynes and Zhao, 2000, J. Cell Biol. 150(2): Table S6. EGF repeat and related adhesion proteins. [FBrf0132110]
Personal communication to FlyBase	Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215] Ryder, 2004.4.26, Exelixis CG deletion data. Exelixis CG deletion data. [FBrf0184335] Mount, 2001.8.14, Intron annotations. Intron annotations. [FBrf0137489]
Abstract	Parra-Peralbo and Culi, 2007, Europ. Dros. Res. Conf. 20: A065 THE DROSOPHILA LDLR PROTEIN LRP1 MODULATES BMP SIGNALING. [FBrf0199624] Soukup and Gubb, 2007, Europ. Dros. Res. Conf. 20: J021 IDENTIFICATION OF THE TRAFFICKING RECEPTOR OF THE SERPIN DEGRADATION PATHWAY DURING THE INNATE IMMUNE RESPONSE. [FBrf0199900]
FlyBase analysis	FlyBase Genome Annotators, 2002-2003, Changes affecting gene model number or type in releases 3.0 and 3.1 of the annotated D.melanogaster genome. Changes affecting gene model number or type in releases 3.0 and 3.1 of the annotated D.melanogaster genome. [FBrf0148886] FlyBase, 1992-, FlyBase curation FlyBase curation. [FBrf0105495]
Computer file	Gene Disruption Project members and Exelixis, 2005, Genomic mapping of Exelixis insertion collection. Genomic mapping of Exelixis insertion collection. [FBrf0184340] Gene Disruption Project members, 2001-, [title not yet available] [title not yet available] [FBrf0132177] BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0125078]
Curated genome annotation	Ashburner, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126651]