Gene Dmel\CG31961

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General Information

Symbol

Dmel\CG31961

Species

D. melanogaster

Name

CG31961

Annotation symbol

CG31961

Feature type

protein_coding_gene

FlyBase ID

FBgn0051961

Created / Updated

2004-09-02/2004-09-02

Genomic Location

Chromosome (arm)

Recombination map

Cytogenetic map

24D8-24D8

Sequence location

2L:4,186,245..4,187,789 [-]

Map ( GBrowse )

Summary Information

Automatically generated summary

See sections below for more information

This gene is referred to in FlyBase by the symbol CG31961 (FBgn0051961). It has the cytological map location 24D8. Its sequence location is 2L:4186245..4187789. Its molecular function is described as binding. It is involved in the biological process tubulin folding. 4 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides.

Detailed Mapping Data

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

24D8-24D8

Limits computationally determined from genome sequence between P{lacW}ed^k01102 and P{PZ}tutl⁰¹⁰⁸⁵

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

Left of (cM)

Right of (cM)

Notes

Molecular Map Data

Gene Order (in direction of increasing cytology)

References

Gene Order (overall orientation not stated)

References

Gene Model & Products

Please see the GBrowse view of Dmel\CG31961 for information on other features

Comments on Gene Model

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Associated CDS (aa)

CG31961-RA

FBtr0077484

NM_164570

1334

355

CG31961-RB

FBtr0077485

NM_164571

1478

355

Additional Transcript Data & Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kD)

Length (aa)

Theoretical pI

RefSeq ID

GenBank protein

CG31961-PA

FBpp0077173

40.5

355

7.38

NP_722959

AAN11167

CG31961-PB

FBpp0077174

40.5

355

7.38

NP_722960

AAN11168

Additional Polypeptide Data & Comments

Reported size (kD)

Comments

External Data

Linkouts

PANTHER - Protein classification by function, families, and pathways

•

FBgn0051961

Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

CARP motif (IPR006599)

Tubulin binding cofactor C (IPR012945)

Sequences Consistent with the Gene Model

DDBJ /
EMBL /
GenBank

DNA sequence

Protein sequence

Name

Q95TP0

Maps to

Does NOT map to

Identified with

LD34582

(BDGP Project Members, 2000-)

Mapped Features & Mutations

Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here

Type

Symbol & Location

Additional Notes

References

External Data

Linkouts

DEDB - Drosophila exon database: splicing graphs

•

5384

Crossreferences

Expression Data

FlyBase-Curated Data

Transcript and
Protein data

Please see the FlyBase Gene Expression Report for details of gene expression from the literature.

Summary of Transcript Expression

Stage

Tissue/Position

Reference

Marker for

Subcellular Localization

CV Term

Summary of Polypeptide Expression

Stage

Tissue/Position

Reference

Marker for

Subcellular Localization

CV Term

External Data & Images

Linkouts

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0051961

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

•

FBgn0051961

GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies

•

FBgn0051961

Alleles & Phenotypes

Summary of Allele Phenotypes

Lethality

Allele

viable

CG31961^f06868

Sterility

Allele

fertile

CG31961^f06868

Phenotype manifest in

Allele

Classical Alleles ( 3 )

For All Classical Alleles Show

Allele of CG31961	Mutagen	Stocks	Known lesion
CG31961^c00729	piggyBac transposase	1	--
CG31961^e00791	piggyBac transposase	1	--
CG31961^f06868	piggyBac transposase	2	--

Alleles Carried on Transgenic Constructs ( 1 )

For All Alleles Carried on Transgenic Constructs Show

Allele of CG31961	Class	Mutagen	Stocks	Known lesion
CG31961^GD14747		in vitro construct \| RNAi in vitro construct \| regulatory fusion	2	Yes

Aneuploid Aberrations

Useful deficiency

Df(2L)M24F11

Transgenic Constructs & Insertions

Transgenic Constructs

Type of construct

Name

Expression data

UAS construct

P{GD14747}

Insertions

Type of insertions

Name

Expression data

miscellaneous insertions

PBac{PB}CG31961^c00729

PBac{RB}CG31961^e00791

PBac{WH}CG31961^f06868

Related Comments

Please look at the allele reports for the complete phenotype data

Gene Ontology: Function, Process & Cellular Component ( 2 )

Molecular Function

CV term

Evidence

References

binding

inferred from electronic annotation with InterPro:IPR006599

(FlyBase Curators et al., 2004-)

Biological Process

CV term

Evidence

References

tubulin folding

inferred from sequence or structural similarity with UniProtKB:Q15814

(FlyBase Genome Annotators, 2004)

Cellular Component

CV term

Evidence

References

Sequence Ontology: Class of Gene

protein_coding_gene

nuclear_gene

Interactions & Pathways

Summary of Genetic Interactions

Interacts with

Please look at the allele data for full details of the genetic interactions

CG31961 allele

Gene

References

External Data

Linkouts

BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions

•

77327

Orthologs

Genome-wide drosophilid orthologs

Dana\GF24566

Dere\GG24392

Dgri\GH10233

Dmoj\GI15190

Dper\GL19291

Dpse\GA16589

Dsec\GM18108

Dsim\GD11992

Dvir\GJ17259

Dwil\GK23765

Dyak\GE14769

Curated drosophilid orthologs

Dpse\GA16589

Linkouts

InParanoid orthologs - Eukaryotic orthologs

•

ENSANGP00000011106
Anopheles gambiae (Ensembl)
ENSBTAP00000001245
Bos taurus (Ensembl)
ENSCAFP00000002507
Canis familiaris (Ensembl)
NEWSINFRUP00000144410
Takifugu rubripes (Ensembl)
ENSGALP00000016099
Gallus gallus (Ensembl)
ENSP00000244625
Homo sapiens (Ensembl)
ENSMMUP00000001740
Macaca mulatta (Ensembl)
ENSMODP00000023695
Monodelphis domestica (Ensembl)
ENSPTRP00000031050
Pan troglodytes (Ensembl)
ENSRNOP00000021555
Rattus norvegicus (Ensembl)
GSTENP00025535001
Tetraodon nigroviridis (Ensembl)
ENSXETP00000000453
Xenopus tropicalis (Ensembl)
Q6YVY3
Oryza sativa (Gramene)
AT4G39920.1
Arabidopsis thaliana (Arabidopsis)
WBGene00031340
Caenorhabditis briggsae (Wormbase)
WBGene00044609
Caenorhabditis elegans (Wormbase)
MGI:1919976
Mus musculus (Informatics)
SPAC328.08c
Schizosaccharomyces pombe (Sanger)

Functional Complementation between Species

Inter-Species Misexpression Data

Produces phenotype in

Produces NO phenotype in

Stocks & Reagents

Stocks Listed in FlyBase ( 6 )

Harvard

PBac{PB}CG31961^c00729

PBac{RB}CG31961^e00791

PBac{WH}CG31961^f06868

VDRC

v29359

w¹¹¹⁸; P{GD14747}v29359

v29360

w¹¹¹⁸; P{GD14747}v29360

Bloomington

19020

w¹¹¹⁸; PBac{WH}CG31961^f06868

Genomic Clones ( 1 )

BACR11D14

cDNA Clones ( 10 )

Please Note

This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA Clones, Fully Sequenced

BDGP DGC clones

LD34582

Other clones

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi & Array Information

Affy Oligo

Linkouts

DRSC - RNAi screening (Harvard): high-throughput cell culture data and design

•

FBgn0051961

GenomeRNAi - RNAi phenotypes (Heidelberg): high-throughput cell culture data

•

FBgn0051961

Antibody Information

Other Information

Discoverer

Etymology

Identification

Position Effect Variegation Data

Relationship to Other Genes

Source for database identity of

Source for database merge of

Source for merge of: CG31961 BcDNA:LD34582 Source for merge of CG31961 BcDNA:LD34582 was a shared cDNA (date:030728).

(FlyBase, 1996-)

Additional comments

Comments About Role

Comments About Molecular Function

Other Comments

Annotation CG3381 was eliminated in the July 2000 Celera release of annotated sequence and was restored as CG31961 in release 3 of the genome annotation.

(FlyBase Genome Annotators, 2002-2003)

External Crossreferences & Linkouts

Sequence Crossreferences

RefSeq (Transcripts)

•

RefSeq (Proteins)

•

DDBJ / EMBL / GenBank

•

UniProtKB/TrEMBL

•

Q95TP0

Other Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

CARP motif (IPR006599)

Tubulin binding cofactor C (IPR012945)

Linkouts

BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions

•

77327

DEDB - Drosophila exon database: splicing graphs

•

5384

DRSC - RNAi screening (Harvard): high-throughput cell culture data and design

•

FBgn0051961

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0051961

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

•

FBgn0051961

FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans

•

FBgn0051961

GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies

•

FBgn0051961

GenomeRNAi - RNAi phenotypes (Heidelberg): high-throughput cell culture data

•

FBgn0051961

InParanoid orthologs - Eukaryotic orthologs

•

ENSANGP00000011106
Anopheles gambiae (Ensembl)
ENSBTAP00000001245
Bos taurus (Ensembl)
ENSCAFP00000002507
Canis familiaris (Ensembl)
NEWSINFRUP00000144410
Takifugu rubripes (Ensembl)
ENSGALP00000016099
Gallus gallus (Ensembl)
ENSP00000244625
Homo sapiens (Ensembl)
ENSMMUP00000001740
Macaca mulatta (Ensembl)
ENSMODP00000023695
Monodelphis domestica (Ensembl)
ENSPTRP00000031050
Pan troglodytes (Ensembl)
ENSRNOP00000021555
Rattus norvegicus (Ensembl)
GSTENP00025535001
Tetraodon nigroviridis (Ensembl)
ENSXETP00000000453
Xenopus tropicalis (Ensembl)
Q6YVY3
Oryza sativa (Gramene)
AT4G39920.1
Arabidopsis thaliana (Arabidopsis)
WBGene00031340
Caenorhabditis briggsae (Wormbase)
WBGene00044609
Caenorhabditis elegans (Wormbase)
MGI:1919976
Mus musculus (Informatics)
SPAC328.08c
Schizosaccharomyces pombe (Sanger)

PANTHER - Protein classification by function, families, and pathways

•

FBgn0051961

Synonyms & Secondary IDs ( 3 )

Reported As

Symbol Synonym

BcDNA:LD34582

CG3381

CG31961

Name Synonym

CG31961

Secondary FlyBase IDs

FBgn0031587
FBgn0046772

References ( 10 )

Supplementary material

Giot et al., 2003, Science 302(5651):: Tables S1 to S7. [FBrf0166452]

Personal communication to FlyBase

Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center: RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327]
Bloomington Drosophila Stock Center, 2004.11.6, Exelixis insertion alleles that are not in FlyBase.: Exelixis insertion alleles that are not in FlyBase. [FBrf0179797]
FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms.: Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215]

FlyBase analysis

FlyBase Genome Annotators, 2004, Changes affecting gene model number or type in release 3.2 of the annotated D.melanogaster genome.: Changes affecting gene model number or type in release 3.2 of the annotated D.melanogaster genome. [FBrf0166453]
FlyBase Genome Annotators, 2002-2003, Changes affecting gene model number or type in releases 3.0 and 3.1 of the annotated D.melanogaster genome.: Changes affecting gene model number or type in releases 3.0 and 3.1 of the annotated D.melanogaster genome. [FBrf0148886]
FlyBase, 1996-, FlyBase inference based on genome sequence analysis.: FlyBase inference based on genome sequence analysis. [FBrf0104946]

Computer file

Gene Disruption Project members and Exelixis, 2005, Genomic mapping of Exelixis insertion collection.: Genomic mapping of Exelixis insertion collection. [FBrf0184340]
Gene Disruption Project members, 2001-, [title not yet available]: [title not yet available] [FBrf0132177]
BDGP Project Members, 2000-, Berkeley Drosophila Genome Project.: Berkeley Drosophila Genome Project. [FBrf0125078]