Gene Dmel\Tango11

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General Information

Symbol

Dmel\Tango11

Species

D. melanogaster

Name

Transport and Golgi organization

Annotation symbol

CG30404

Feature type

protein_coding_gene

FlyBase ID

FBgn0050404

Created / Updated

2003-12-01/2003-12-01

Genomic Location

Chromosome (arm)

Recombination map

Cytogenetic map

57F10-57F10

Sequence location

2R:17,604,280..17,607,466 [-]

Map ( GBrowse )

Summary Information

Automatically generated summary

See sections below for more information

The gene Transport and Golgi organization is referred to in FlyBase by the symbol Tango11 (CG30404, FBgn0050404). It has the cytological map location 57F10. Its sequence location is 2R:17604280..17607466. Its molecular function is unknown. The biological processes in which it is involved are not known. 5 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides.

Detailed Mapping Data

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

57F10-57F10

Limits computationally determined from genome sequence between P{EP}Tim10^EP541&P{lacW}l(2)k09617^k09617 and P{PZ}l(2)07837⁰⁷⁸³⁷

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

Left of (cM)

Right of (cM)

Notes

Molecular Map Data

Gene Order (in direction of increasing cytology)

References

Gene Order (overall orientation not stated)

References

Gene Model & Products

Please see the GBrowse view of Dmel\Tango11 for information on other features

Comments on Gene Model

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Associated CDS (aa)

Tango11-RA

FBtr0071746

NM_166481

1632

277

Tango11-RB

FBtr0071747

NM_166482

1687

277

Additional Transcript Data & Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kD)

Length (aa)

Theoretical pI

RefSeq ID

GenBank protein

Tango11-PA

FBpp0071660

31.5

277

6.13

NP_726111

AAM71012

Tango11-PB

FBpp0071661

31.5

277

6.13

NP_726112

AAM71013

Additional Polypeptide Data & Comments

Reported size (kD)

Comments

External Data

Linkouts

PANTHER - Protein classification by function, families, and pathways

•

FBgn0050404

Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

Protein of unknown function DUF800 (IPR008518)

Sequences Consistent with the Gene Model

DDBJ /
EMBL /
GenBank

DNA sequence

Protein sequence

Name

Q961C9

Maps to

Does NOT map to

Identified with

(Oliver, 2001.8.16)

LD22567

(BDGP Project Members, 2000-)

Mapped Features & Mutations

Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here

Type

Symbol & Location

Additional Notes

References

External Data

Linkouts

DEDB - Drosophila exon database: splicing graphs

•

1263

Crossreferences

Expression Data

FlyBase-Curated Data

Transcript and
Protein data

Please see the FlyBase Gene Expression Report for details of gene expression from the literature.

Summary of Transcript Expression

Stage

Tissue/Position

Reference

Marker for

Subcellular Localization

CV Term

Summary of Polypeptide Expression

Stage

Tissue/Position

Reference

Marker for

Subcellular Localization

CV Term

External Data & Images

Linkouts

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0050404

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

•

FBgn0050404

Alleles & Phenotypes

Summary of Allele Phenotypes

Phenotype manifest in

Allele

Classical Alleles ( 3 )

For All Classical Alleles Show

Allele of Tango11	Mutagen	Stocks	Known lesion
Tango11^GS2162		0	--
Tango11^c02574	piggyBac transposase	1	--
Tango11^f03353	piggyBac transposase	1	--

Alleles Carried on Transgenic Constructs ( 2 )

For All Alleles Carried on Transgenic Constructs Show

Allele of Tango11	Class	Mutagen	Stocks	Known lesion
Tango11^GD14824		in vitro construct \| RNAi in vitro construct \| regulatory fusion	1	Yes
Tango11^T:SV5\V5		in vitro construct \| coding region fusion	0	Yes

Aneuploid Aberrations

Useful deficiency

Df(2R)XE-2900

Useful duplication

Dp(2;2)l-32

Disrupted in

Df(2R)Exel6077

(Ryder, 2004.4.26)

Transgenic Constructs & Insertions

Transgenic Constructs

Type of construct

Name

Expression data

UAS construct

P{GD14824}

Insertions

Type of insertions

Name

Expression data

miscellaneous insertions

PBac{PB}Tango11^c02574

PBac{WH}Tango11^f03353

insertion of enhancer trap

P{lacW}l(2)SH0978^SH0978

insertion of mobile activating element

P{GSV1}EP-439^EP-439

P{GSV1}LBR^GS2162

Related Comments

Please look at the allele reports for the complete phenotype data

dsRNA directed against Tango11 inhibits protein secretion in S2 cells, but has no apparent effect on Golgi organisation.

(Bard et al., 2006)

Gene Ontology: Function, Process & Cellular Component ( 3 )

Molecular Function

CV term

Evidence

References

molecular_function

no biological data available

(FlyBase Curators, 2002-)

Biological Process

CV term

Evidence

References

biological_process

no biological data available

(FlyBase Curators, 2002-)

Cellular Component

CV term

Evidence

References

endoplasmic reticulum

inferred from direct assay

(Bard et al., 2006)

Sequence Ontology: Class of Gene

protein_coding_gene

nuclear_gene

Interactions & Pathways

Summary of Genetic Interactions

Interacts with

Please look at the allele data for full details of the genetic interactions

Tango11 allele

Gene

References

External Data

Linkouts

BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions

•

73152

Drosophila PIMRider - The Drosophila Protein Interaction map

•

522397

Orthologs

Genome-wide drosophilid orthologs

Dana\GF11620

Dere\GG20746

Dgri\GH20782

Dmoj\GI20865

Dper\GL17521

Dpse\GA15821

Dsec\GM15690

Dsim\GD25169

Dvir\GJ20601

Dwil\GK15656

Dyak\GE13678

Curated drosophilid orthologs

Dpse\GA15821

Linkouts

InParanoid orthologs - Eukaryotic orthologs

•

ENSANGP00000012821
Anopheles gambiae (Ensembl)
ENSBTAP00000028421
Bos taurus (Ensembl)
ENSCAFP00000015350
Canis familiaris (Ensembl)
NEWSINFRUP00000158323
Takifugu rubripes (Ensembl)
ENSGALP00000004861
Gallus gallus (Ensembl)
ENSP00000302037
Homo sapiens (Ensembl)
ENSMMUP00000024961
Macaca mulatta (Ensembl)
ENSMODP00000026509
Monodelphis domestica (Ensembl)
ENSPTRP00000022220
Pan troglodytes (Ensembl)
ENSRNOP00000046637
Rattus norvegicus (Ensembl)
GSTENP00015004001
Tetraodon nigroviridis (Ensembl)
ZDB-CDNA-040425-2444
Danio rerio (Zfin)
ZDB-GENE-040426-1510
Danio rerio (Zfin)
MGI:1922984
Mus musculus (Informatics)

Functional Complementation between Species

Inter-Species Misexpression Data

Produces phenotype in

Produces NO phenotype in

Stocks & Reagents

Stocks Listed in FlyBase ( 4 )

Harvard

PBac{PB}Tango11^c02574

PBac{WH}Tango11^f03353

Szeged

P{lacW}l(2)SH0978^SH0978

VDRC

v29385

w¹¹¹⁸; P{GD14824}v29385/TM3

Genomic Clones ( 2 )

cDNA Clones ( 48 )

Please Note

This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA Clones, Fully Sequenced

BDGP DGC clones

LD22567

Other clones

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi & Array Information

Affy Oligo

Linkouts

DRSC - RNAi screening (Harvard): high-throughput cell culture data and design

•

FBgn0050404

GenomeRNAi - RNAi phenotypes (Heidelberg): high-throughput cell culture data

•

FBgn0050404

Antibody Information

Other Information

Discoverer

Etymology

Identification

Position Effect Variegation Data

Relationship to Other Genes

Source for database identity of

Source for identity of: Tango11 CG30404

(Bard et al., 2006)

Source for database merge of

Source for merge of: CG30404 BEST:LD33633

(Rana, 2004.7.8)

Source for merge of: CG30404 anon-EST:fe1F11 Source for merge of: CG30404 BcDNA:LD22567 Source for merge of CG30404 anon-EST:fe1F11 was sequence comparison (date:030707). Source for merge of CG30404 BcDNA:LD22567 was a shared cDNA (date:030728).

(FlyBase, 1996-)

Additional comments

Comments About Role

Comments About Molecular Function

Other Comments

New annotation (CG30404) in release 3 of the genome annotation.

(FlyBase Genome Annotators, 2002-2003)

dsRNA directed against this gene has been used in a screen for genes required for constitutive protein secretion.

(Bard et al., 2006)

External Crossreferences & Linkouts

Sequence Crossreferences

RefSeq (Transcripts)

•

RefSeq (Proteins)

•

DDBJ / EMBL / GenBank

•

UniProtKB/TrEMBL

•

Q961C9

Other Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

Protein of unknown function DUF800 (IPR008518)

Linkouts

BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions

•

73152

DEDB - Drosophila exon database: splicing graphs

•

1263

DRSC - RNAi screening (Harvard): high-throughput cell culture data and design

•

FBgn0050404

Drosophila PIMRider - The Drosophila Protein Interaction map

•

522397

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0050404

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

•

FBgn0050404

FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans

•

FBgn0050404

GenomeRNAi - RNAi phenotypes (Heidelberg): high-throughput cell culture data

•

FBgn0050404

InParanoid orthologs - Eukaryotic orthologs

•

ENSANGP00000012821
Anopheles gambiae (Ensembl)
ENSBTAP00000028421
Bos taurus (Ensembl)
ENSCAFP00000015350
Canis familiaris (Ensembl)
NEWSINFRUP00000158323
Takifugu rubripes (Ensembl)
ENSGALP00000004861
Gallus gallus (Ensembl)
ENSP00000302037
Homo sapiens (Ensembl)
ENSMMUP00000024961
Macaca mulatta (Ensembl)
ENSMODP00000026509
Monodelphis domestica (Ensembl)
ENSPTRP00000022220
Pan troglodytes (Ensembl)
ENSRNOP00000046637
Rattus norvegicus (Ensembl)
GSTENP00015004001
Tetraodon nigroviridis (Ensembl)
ZDB-CDNA-040425-2444
Danio rerio (Zfin)
ZDB-GENE-040426-1510
Danio rerio (Zfin)
MGI:1922984
Mus musculus (Informatics)

PANTHER - Protein classification by function, families, and pathways

•

FBgn0050404

Synonyms & Secondary IDs ( 8 )

Reported As

Symbol Synonym

anon-EST:fe1F11

BcDNA:LD22567

BEST:LD33633

CG30404

(Bard et al., 2006, Giot et al., 2003, Laviolette et al., 2005, Molnar et al., 2006)

TANGO11

(Bard et al., 2006)

Tango11

Name Synonym

anon-fast-evolving-1F11

Transport and Golgi organization

(Bard et al., 2006)

Secondary FlyBase IDs

FBgn0025252
FBgn0045785
FBgn0046223

References ( 18 )

Research paper

Bard et al., 2006, Nature 439(7076): 604--607: Functional genomics reveals genes involved in protein secretion and Golgi organization. [FBrf0191232]
Molnar et al., 2006, Genetics 174(3): 1635--1659: A gain-of-function screen identifying genes required for vein formation in the Drosophila melanogaster wing. [FBrf0195387]
Laviolette et al., 2005, Genetics 170(2): 779--792: A genetic screen for suppressors of Drosophila NSF2 neuromuscular junction overgrowth. [FBrf0187645]
Schmid and Tautz, 1997, Proc. Natl. Acad. Sci. USA 94(18): 9746--9750: A screen for fast evolving genes from Drosophila. [FBrf0098343]

Supplementary material

Giot et al., 2003, Science 302(5651):: Tables S1 to S7. [FBrf0166452]
Oh et al., 2003, Genetics 163(1):: Table S1. [FBrf0157097]

Personal communication to FlyBase

Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center: RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327]
Rana, 2004.7.8, BLAST analysis.: BLAST analysis. [FBrf0178762]
Ryder, 2004.4.26, Exelixis CG deletion data.: Exelixis CG deletion data. [FBrf0184335]
Oliver, 2001.8.16, File from B. Oliver containing information on ESTs expressed in the Drosophila testis, described in Andrews et al., 2000, Genome Res. 10(12): 2030-2043 (FBrf0132348).: File from B. Oliver containing information on ESTs expressed in the Drosophila testis, described in Andrews et al., 2000, Genome Res. 10(12): 2030-2043 (FBrf0132348). [FBrf0137492]
Bayraktaroglu, 2000.11.2, Current list of possibly CG-able known genes.: Current list of possibly CG-able known genes. [FBrf0131225]

FlyB