Gene Dmel\mir-11

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General Information

Symbol

Dmel\mir-11

Species

D. melanogaster

Name

mir-11

Annotation symbol

CR32929

Feature type

miRNA_gene

FlyBase ID

FBgn0046832

Created / Updated

2003-12-01/2003-12-01

Genomic Location

Chromosome (arm)

Recombination map

Cytogenetic map

93E9-93E9

Sequence location

3R:17,448,226..17,448,246 [-]

Map ( GBrowse )

Summary Information

Automatically generated summary

See sections below for more information

This gene is referred to in FlyBase by the symbol mir-11 (CR32929, FBgn0046832). It has the cytological map location 93E9. Its sequence location is 3R:17448226..17448246. Its molecular function is unknown. The biological processes in which it is involved are not known. One allele is reported. No phenotypic data is available. It has one annotated transcript.

Detailed Mapping Data

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

93E9-93E9

Limits computationally determined from genome sequence between P{PZ}InR⁰⁵⁵⁴⁵ and P{PZ}tsl⁰⁰⁶¹⁷

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

Left of (cM)

Right of (cM)

Notes

Molecular Map Data

Gene Order (in direction of increasing cytology)

References

Gene Order (overall orientation not stated)

References

Gene Model & Products

Please see the GBrowse view of Dmel\mir-11 for information on other features

Comments on Gene Model

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

mir-11-RA

FBtr0084120

NR_002070

Additional Transcript Data & Comments

Reported size (kB)

Comments

External Data

Crossreferences

miRBase - the home of microRNA data

•

MI0000131

Sequences Consistent with the Gene Model

DDBJ /
EMBL /
GenBank

DNA sequence

Name

AJ421771

Maps to

Does NOT map to

Identified with

Mapped Features & Mutations

Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here

Type

Symbol & Location

Additional Notes

References

External Data

Linkouts

Crossreferences

Expression Data

FlyBase-Curated Data

Transcript data

Please see the FlyBase Gene Expression Report for details of gene expression from the literature.

Summary of Transcript Expression

Stage

Tissue/Position

Reference

embryonic stage-adult stage

(Sempere et al., 2003)

Marker for

Subcellular Localization

CV Term

External Data & Images

Linkouts

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0046832

Alleles & Phenotypes

Summary of Allele Phenotypes

Phenotype manifest in

Allele

Classical Alleles ( 0 )

For All Classical Alleles Show

Allele of mir-11	Class	Mutagen	Stocks	Known lesion

Alleles Carried on Transgenic Constructs ( 1 )

For All Alleles Carried on Transgenic Constructs Show

Allele of mir-11	Class	Mutagen	Stocks	Known lesion
mir-11^{Scer\UAS.T:Disc\RFP-DsRed2}		in vitro construct \| regulatory fusion	0	Yes

Aneuploid Aberrations

Useful deficiency

Df(3R)e-H4

Useful duplication

Dp(3;3)M95A⁺13

Transgenic Constructs & Insertions

Transgenic Constructs

Type of construct

Name

Expression data

UAS construct

P{UAS-DsRed2-mir-11}

Insertions

Type of insertions

Name

Expression data

Related Comments

Please look at the allele reports for the complete phenotype data

Gene Ontology: Function, Process & Cellular Component ( 0 )

Molecular Function

CV term

Evidence

References

Biological Process

CV term

Evidence

References

Cellular Component

CV term

Evidence

References

Sequence Ontology: Class of Gene

miRNA_gene

(Lagos-Quintana et al., 2001)

nuclear_gene

(Lagos-Quintana et al., 2001)

Interactions & Pathways

Summary of Genetic Interactions

Interacts with

Please look at the allele data for full details of the genetic interactions

mir-11 allele

Gene

References

External Data

Linkouts

BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions

•

533584

Orthologs

Genome-wide drosophilid orthologs

Curated drosophilid orthologs

Dpse\mir-11

Linkouts

Functional Complementation between Species

Inter-Species Misexpression Data

Produces phenotype in

Produces NO phenotype in

Stocks & Reagents

Stocks Listed in FlyBase ( 0 )

Genomic Clones ( 2 )

cDNA Clones ( 0 )

cDNA Clones, Fully Sequenced

BDGP DGC clones

Other clones

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi & Array Information

Affy Oligo

Linkouts

GenomeRNAi - RNAi phenotypes (Heidelberg): high-throughput cell culture data

•

FBgn0046832

Other Information

Discoverer

Etymology

Identification

Position Effect Variegation Data

Relationship to Other Genes

Source for database identity of

Source for database merge of

Additional comments

Comments About Role

Comments About Molecular Function

Other Comments

New annotation (CR32929) in release 3 of the genome annotation.

(FlyBase Genome Annotators, 2002-2003)

External Crossreferences & Linkouts

Sequence Crossreferences

RefSeq (Transcripts)

•

NR_002070

DDBJ / EMBL / GenBank

•

Other Crossreferences

miRBase - the home of microRNA data

•

MI0000131

Linkouts

BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions

•

533584

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0046832

FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans

•

FBgn0046832

GenomeRNAi - RNAi phenotypes (Heidelberg): high-throughput cell culture data

•

FBgn0046832

Synonyms & Secondary IDs ( 4 )

Reported As

Symbol Synonym

CR32929

dme-mir-11

(Gesellchen and Boutros, 2004)

miR-11

(Leaman, 2005, Carthew, 2006, Miska, 2005, Brennecke, 2005, Boutla et al., 2003, Lai et al., 2003, Sempere et al., 2003, Lai, 2002, Lee et al., 2001, Lagos-Quintana et al., 2001, Stark et al., 2003, Stark et al., 2003, Stark et al., 2005)

mir-11

Name Synonym

mir-11

Secondary FlyBase IDs

References ( 19 )

Research paper

Aboobaker et al., 2005, Proc. Natl. Acad. Sci. USA 102(50): 18017--18022: Drosophila microRNAs exhibit diverse spatial expression patterns during embryonic development. [FBrf0191424]
Brennecke, 2005, PLoS Biol. 3(3): 404--418: Principles of MicroRNA-Target Recognition. [FBrf0188411]
Lai et al., 2005, Genes Dev. 19(9): 1067--1080: Pervasive regulation of Drosophila Notch target genes by GY-box-, Brd-box-, and K-box-class microRNAs. [FBrf0187594]
Stark et al., 2005, Cell 123(6): 1133--1146: Animal MicroRNAs confer robustness to gene expression and have a significant impact on 3'UTR evolution. [FBrf0189926]
Aravin et al., 2003, Dev. Cell 5(2): 337--350: The small RNA profile during Drosophila melanogaster development. [FBrf0162058]
Boutla et al., 2003, Nucleic Acids Res. 31(17): 4973--4980: Developmental defects by antisense-mediated inactivation of micro-RNAs 2 and 13 in Drosophila and the identification of putative target genes. [FBrf0162268]
Lai et al., 2003, GenomeBiol. 4(7): R42: Computational identification of Drosophila microRNA genes. [FBrf0160711]
Sempere et al., 2003, Dev. Biol. 259(1): 9--18: Temporal regulation of microRNA expression in Drosophila melanogaster mediated by hormonal signals and Broad-Complex gene activity. [FBrf0160938]
Lai, 2002, Nature Genetics 30(4): 363--364: Micro RNAs are complementary to 3' UTR sequence motifs that mediate negative post-transcriptional regulation. [FBrf0151441]
Lagos-Quintana et al., 2001, Science 294(5543): 853--858: Identification of novel genes coding for small expressed RNAs. [FBrf0141757]

Supplementary material

Leaman, 2005, Cell 121(7):: [title not yet available] [FBrf0191779]
Stark et al., 2003, PLoS Biol. 1(3): DOI:10.1371/journal.pbio.0000060.sd001: Dataset S1. Complete Lists. [FBrf0173091]
Stark et al., 2003, PLoS Biol. 1(3): DOI:10.1371/journal.pbio.0000060.sd002: Dataset S2. Top 100 List. [FBrf0173092]
Lee et al., 2001, Science 294(5543):: Supplemental Table 1. [FBrf0141817]

Review

Carthew, 2006, Curr. Opin. Genet. Dev. 16(2): 203--208: [title not yet available] [FBrf0191600]
Alvarez-Garcia, 2005, Development 132(21): 4653--4662: [title not yet available] [FBrf0191590]
Miska, 2005, Curr. Opin. Genet. Dev. 15(5): 563--568: [title not yet available] [FBrf0191572]
Gesellchen and Boutros, 2004, Differentiation 72(2-3): 74--80: Managing the genome: microRNAs in Drosophila. [FBrf0174593]

FlyBase analysis

FlyBase Genome Annotators, 2002-2003, Changes affecting gene model number or type in releases 3.0 and 3.1 of the annotated D.melanogaster genome.: Changes affecting gene model number or type in releases 3.0 and 3.1 of the annotated D.melanogaster genome. [FBrf0148886]