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Gene Dmel\mir-13a

General Information
Symbol	Dmel\mir-13a	Species	D. melanogaster
Name	mir-13a	Annotation symbol	CR32931
Feature type	miRNA_gene	FlyBase ID	FBgn0046830
Created / Updated	2003-12-01/2003-12-01
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	88F4-88F4	Sequence location	3R:11,243,270..11,243,291 [-]
Map ( GBrowse )	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol mir-13a (CR32931, FBgn0046830). It has the cytological map location 88F4. Its sequence location is 3R:11243270..11243291. Its molecular function is unknown. The biological processes in which it is involved are not known. No alleles are reported. It has one annotated transcript.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 88F4-88F4   Limits computationally determined from genome sequence between P{lacW}MRG15j6A3 and P{PZ}l(3)0653606536
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Molecular Map Data
Gene Order (in direction of increasing cytology) References Gene Order (overall orientation not stated) References Overall orientation not stated: mir-13a? mir-13b-1? (Lagos-Quintana et al., 2001)
Gene Model & Products
Please see the GBrowse view of Dmel\mir-13a for information on other features
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt)   mir-13a-RA FBtr0083103  NR_002027   22
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences	miRBase - the home of microRNA data • MI0000133
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence   Name AJ421773
Maps to
Does NOT map to
Identified with
Mapped Features & Mutations
Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
FlyBase-Curated Data
Transcript data	Please see the FlyBase Gene Expression Report for details of gene expression from the literature.
Summary of Transcript Expression
Stage Tissue/Position Reference  embryonic stage-adult stage   (Sempere et al., 2003)
Marker for
Subcellular Localization
CV Term
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0046830
Alleles & Phenotypes
Summary of Allele Phenotypes
Phenotype manifest in Allele
Classical Alleles ( 0 )
For All Classical Alleles Show
Allele of mir-13a Class Mutagen Stocks Known lesion
Alleles Carried on Transgenic Constructs ( 0 )
For All Alleles Carried on Transgenic Constructs Show
Allele of mir-13a Class Mutagen Stocks Known lesion
Aneuploid Aberrations
Useful duplication	Dp(3;3)C123.3
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data
Insertions
	Type of insertions Name Expression data
Related Comments
	Please look at the allele reports for the complete phenotype data
Gene Ontology: Function, Process & Cellular Component ( 1 )
Molecular Function
CV term Evidence References
Biological Process
CV term Evidence References
Cellular Component
CV term Evidence References
polysome non-traceable author statement (Caudy et al., 2002)
Sequence Ontology: Class of Gene
	miRNA_gene (Lagos-Quintana et al., 2001) nuclear_gene (Lagos-Quintana et al., 2001)
Interactions & Pathways
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions mir-13a allele Gene References
External Data
Linkouts	BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions • 533847
Orthologs
Genome-wide drosophilid orthologs
Curated drosophilid orthologs	Dpse\mir-13a
Linkouts
Functional Complementation between Species
Inter-Species Misexpression Data
Produces phenotype in
Produces NO phenotype in
Stocks & Reagents
Stocks Listed in FlyBase ( 0 )
Genomic Clones ( 1 )
	BACR17K19
cDNA Clones ( 0 )
cDNA Clones, Fully Sequenced
BDGP DGC clones
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones
RNAi & Array Information
Affy Oligo
Linkouts	GenomeRNAi - RNAi phenotypes (Heidelberg): high-throughput cell culture data • FBgn0046830
Other Information
Discoverer
Etymology
Identification
Position Effect Variegation Data
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Comments About Role
Comments About Molecular Function
	mir-2c, mir-13a and mir-13b-1 are clustered within 400bp in 87E7--88F4. (Sempere et al., 2003)
Other Comments
	New annotation (CR32931) in release 3 of the genome annotation. (FlyBase Genome Annotators, 2002-2003)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NR_002027 DDBJ / EMBL / GenBank • AE003708 AJ421773
Other Crossreferences
	miRBase - the home of microRNA data • MI0000133
Linkouts
	BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions • 533847 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0046830 FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0046830 GenomeRNAi - RNAi phenotypes (Heidelberg): high-throughput cell culture data • FBgn0046830
Synonyms & Secondary IDs ( 5 )
Reported As
Symbol Synonym	CR32931   miR-13 (Alvarez-Garcia, 2005, Gesellchen and Boutros, 2004, Sempere et al., 2003, Behura, 2007) miR-13a (Boutla et al., 2003, Lai et al., 2003, Schwarz et al., 2003, Stark et al., 2003, Stark et al., 2003) miR13a (Caudy et al., 2002) mir-13a
Name Synonym	mir-13a
Secondary FlyBase IDs
References ( 16 )
Research paper	Landthaler et al., 2004, Curr. Biol. 14(23): 2162--2167 The human DiGeorge syndrome critical region gene 8 and its D. melanogaster homolog are required for miRNA biogenesis. [FBrf0183815] Aravin et al., 2003, Dev. Cell 5(2): 337--350 The small RNA profile during Drosophila melanogaster development. [FBrf0162058] Boutla et al., 2003, Nucleic Acids Res. 31(17): 4973--4980 Developmental defects by antisense-mediated inactivation of micro-RNAs 2 and 13 in Drosophila and the identification of putative target genes. [FBrf0162268] Lai et al., 2003, GenomeBiol. 4(7): R42 Computational identification of Drosophila microRNA genes. [FBrf0160711] Schwarz et al., 2003, Cell 115(2): 199--208 Asymmetry in the assembly of the RNAi enzyme complex. [FBrf0173162] Sempere et al., 2003, Dev. Biol. 259(1): 9--18 Temporal regulation of microRNA expression in Drosophila melanogaster mediated by hormonal signals and Broad-Complex gene activity. [FBrf0160938] Caudy et al., 2002, Genes Dev. 16(19): 2491--2496 Fragile X-related protein and VIG associate with the RNA interference machinery. [FBrf0152005] Lai, 2002, Nature Genetics 30(4): 363--364 Micro RNAs are complementary to 3' UTR sequence motifs that mediate negative post-transcriptional regulation. [FBrf0151441] Lagos-Quintana et al., 2001, Science 294(5543): 853--858 Identification of novel genes coding for small expressed RNAs. [FBrf0141757]
Supplementary material	Stark et al., 2003, PLoS Biol. 1(3): DOI:10.1371/journal.pbio.0000060.sd001 Dataset S1. Complete Lists. [FBrf0173091] Stark et al., 2003, PLoS Biol. 1(3): DOI:10.1371/journal.pbio.0000060.sd002 Dataset S2. Top 100 List. [FBrf0173092] Lee et al., 2001, Science 294(5543): Supplemental Table 1. [FBrf0141817]
Review	Behura, 2007, Insect Biochem. Molec. Biol. 37(1): 3--9 Insect microRNAs: Structure, function and evolution. [FBrf0194885] Alvarez-Garcia, 2005, Development 132(21): 4653--4662 [title not yet available] [FBrf0191590] Gesellchen and Boutros, 2004, Differentiation 72(2-3): 74--80 Managing the genome: microRNAs in Drosophila. [FBrf0174593]
FlyBase analysis	FlyBase Genome Annotators, 2002-2003, Changes affecting gene model number or type in releases 3.0 and 3.1 of the annotated D.melanogaster genome. Changes affecting gene model number or type in releases 3.0 and 3.1 of the annotated D.melanogaster genome. [FBrf0148886]