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Gene Dmel\mir-2b-1

General Information
Symbol	Dmel\mir-2b-1	Species	D. melanogaster
Name	mir-2b-1	Annotation symbol	CR32990
Feature type	miRNA_gene	FlyBase ID	FBgn0046824
Created / Updated	2003-12-01/2003-12-01
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	29A1-29A1	Sequence location	2L:8,258,623..8,258,645 [-]
Map ( GBrowse )	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol mir-2b-1 (CR32990, FBgn0046824). It has the cytological map location 29A1. Its sequence location is 2L:8258623..8258645. Its molecular function is unknown. It is involved in the biological process negative regulation of translational initiation. No alleles are reported. It has one annotated transcript.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 29A1-29A1   Limits computationally determined from genome sequence between P{lacW}l(2)k16919k16919&P{lacW}Bsgk09030 and P{lacW}Btk29Ak00206&P{EP}Btk29AEP715
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Molecular Map Data
Gene Order (in direction of increasing cytology) References Gene Order (overall orientation not stated) References
Gene Model & Products
Please see the GBrowse view of Dmel\mir-2b-1 for information on other features
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt)   mir-2b-1-RA FBtr0079619  NR_001624   23
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences	miRBase - the home of microRNA data • MI0000119
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence   Name AJ421759
Maps to
Does NOT map to
Identified with
Mapped Features & Mutations
Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
FlyBase-Curated Data
Transcript data	Please see the FlyBase Gene Expression Report for details of gene expression from the literature.
Summary of Transcript Expression
Stage Tissue/Position Reference  embryonic stage-adult stage   (Sempere et al., 2003)
Marker for
Subcellular Localization
CV Term
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0046824
Alleles & Phenotypes
Summary of Allele Phenotypes
Phenotype manifest in Allele
Classical Alleles ( 0 )
For All Classical Alleles Show
Allele of mir-2b-1 Class Mutagen Stocks Known lesion
Alleles Carried on Transgenic Constructs ( 0 )
For All Alleles Carried on Transgenic Constructs Show
Allele of mir-2b-1 Class Mutagen Stocks Known lesion
Aneuploid Aberrations
Useful deficiency	Df(2L)TE29Aa-11
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data
Insertions
	Type of insertions Name Expression data
Related Comments
	Please look at the allele reports for the complete phenotype data
Gene Ontology: Function, Process & Cellular Component ( 1 )
Molecular Function
CV term Evidence References
Biological Process
CV term Evidence References
negative regulation of translational initiation inferred from direct assay (Thermann and Hentze, 2007)
Cellular Component
CV term Evidence References
Sequence Ontology: Class of Gene
	miRNA_gene (Lagos-Quintana et al., 2001) nuclear_gene (Lagos-Quintana et al., 2001)
Interactions & Pathways
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions mir-2b-1 allele Gene References
External Data
Linkouts	BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions • 533819
Orthologs
Genome-wide drosophilid orthologs
Curated drosophilid orthologs	Dpse\mir-2b-1
Linkouts
Functional Complementation between Species
Inter-Species Misexpression Data
Produces phenotype in
Produces NO phenotype in
Stocks & Reagents
Stocks Listed in FlyBase ( 0 )
Genomic Clones ( 1 )
	BACR15P08
cDNA Clones ( 0 )
cDNA Clones, Fully Sequenced
BDGP DGC clones
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones
RNAi & Array Information
Affy Oligo
Linkouts	GenomeRNAi - RNAi phenotypes (Heidelberg): high-throughput cell culture data • FBgn0046824
Other Information
Discoverer
Etymology
Identification
Position Effect Variegation Data
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Comments About Role
Comments About Molecular Function
	"mir-2" inhibits translation initiation without affecting mRNA stability. (Thermann and Hentze, 2007)
Other Comments
	New annotation (CR32990) in release 3 of the genome annotation. (FlyBase Genome Annotators, 2002-2003)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NR_001624 DDBJ / EMBL / GenBank • AE003620 AJ421759
Other Crossreferences
	miRBase - the home of microRNA data • MI0000119
Linkouts
	BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions • 533819 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0046824 FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0046824 GenomeRNAi - RNAi phenotypes (Heidelberg): high-throughput cell culture data • FBgn0046824
Synonyms & Secondary IDs ( 9 )
Reported As
Symbol Synonym	CR32990   dme-mir-2b-1 (Gesellchen and Boutros, 2004) miR-2 (Carthew, 2006, Miska, 2005, Landthaler et al., 2004, He and Hannon, 2004, Bartel, 2004, Grosshans and Slack, 2002, Sempere et al., 2003) miR2 (Thermann and Hentze, 2007) miR-2b (Alvarez-Garcia, 2005, Miska, 2005, Okamura et al., 2004, Gesellchen and Boutros, 2004, Boutla et al., 2003, Lai, 2003, Carthew, 2002, Ishizuka et al., 2002, Lee et al., 2001, Lagos-Quintana et al., 2001, Stark et al., 2003, Stark et al., 2003, Stark et al., 2005, Behura, 2007) miR2b (Tang, 2005, Caudy et al., 2002, Thermann and Hentze, 2007) mir-2b (Stark et al., 2003, Sempere et al., 2003) miR-2b-1 (Lai et al., 2003, Lai, 2002) mir-2b-1
Name Synonym	mir-2b-1
Secondary FlyBase IDs
References ( 29 )
Generate a list of	All references relating to this gene ( 29 )
List References by type	Research paper  ( 14 ) Supplementary material  ( 3 ) Review  ( 11 ) FlyBase analysis  ( 1 )
Recent research papers ( 1 )
	Thermann and Hentze, 2007, Nature 447(7146): 875--878 Drosophila miR2 induces pseudo-polysomes and inhibits translation initiation. [FBrf0202080] Show all research papers ...
Recent reviews ( 2 )
	Behura, 2007, Insect Biochem. Molec. Biol. 37(1): 3--9 Insect microRNAs: Structure, function and evolution. [FBrf0194885] Carthew, 2006, Curr. Opin. Genet. Dev. 16(2): 203--208 [title not yet available] [FBrf0191600] Show all reviews ...