A Database of Drosophila Genes & Genomes

 

Gene Dmel\mir-2b-2

General Information
SymbolDmel\mir-2b-2SpeciesD. melanogaster
Namemir-2b-2Annotation symbolCR32964
Feature typemiRNA_geneFlyBase IDFBgn0046823
Created / Updated2003-12-01/2003-12-01
Genomic Location
Chromosome (arm)2LRecombination map
Cytogenetic map 37F2-37F2 Sequence location2L:19,570,188..19,570,211 [-]
Map ( GBrowse ) detailed view
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Automatically generated summary

See sections below for more information
This gene is referred to in FlyBase by the symbol mir-2b-2 (CR32964, FBgn0046823). It has the cytological map location 37F2. Its sequence location is 2L:19570189..19570211. Its molecular function is unknown. It is involved in the biological process negative regulation of translational initiation. 3 alleles are reported. No phenotypic data is available. It has one annotated transcript.
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FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
37F2-37F2  
Limits computationally determined from genome sequence between P{EP}EP623&P{PZ}spi01068 and P{lacW}l(2)k10239k10239  
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Molecular Map Data
Gene Order (in direction of increasing cytology)
References
Gene Order (overall orientation not stated)
References
Overall orientation not stated: mir-2b-2? mir-2a-1? mir-2a-2?
(Lagos-Quintana et al., 2001)
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Please see the GBrowse view of Dmel\mir-2b-2 for information on other features
detailed view FBtr0081271 FBtr0081272 FBtr0081270 FBtr0081269 FBtr0100597 FBtr0081267 FBtr0081268 FBpp0080810 FBpp0080809 FBpp0080811 FBpp0080808 FBpp0080812 FBpp0100054 FBpp0080813 FBti0002313 FBti0002314 FBti0056289 FBti0016417 FBti0011296 FBti0056417
Comments on Gene Model
hide Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
 
mir-2b-2-RA
FBtr0081273
 NR_001669
  23
 
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
miRBase - the home of microRNA data
•
hide Sequences Consistent with the Gene Model
DDBJ /
EMBL /
GenBank
DNA sequence
 
Name
AJ421760
 
 
Maps to
Does NOT map to
Identified with
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Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here
Type
Symbol & Location
Additional Notes
References
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Linkouts
Crossreferences
hide Expression Data
FlyBase-Curated Data
Transcript data Please see the FlyBase Gene Expression Report for details of gene expression from the literature.
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Stage
Tissue/Position
Reference
 embryonic stage-adult stage
 
(Sempere et al., 2003)
Marker for
    Subcellular Localization
    CV Term
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    Linkouts
    FLIGHT - Cell culture data for RNAi and other high-throughput technologies
    •
    hide Alleles & Phenotypes
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    Phenotype manifest in
    Allele
    hide Classical Alleles ( 0 )
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    Allele of mir-2b-2ClassMutagenStocksKnown lesion
    hide Alleles Carried on Transgenic Constructs ( 3 )
    For All Alleles Carried on Transgenic Constructs Show

    Allele of mir-2b-2ClassMutagenStocksKnown lesion
    mir-2b-2Scer\UAS.T:Disc\RFP-DsRed20 Yes
    mir-2b-2Scer\UAS.cLa0 Yes
    mir-2b-2mir2.Scer\UAS.T:Disc\RFP-DsRed20 Yes
    hide Aneuploid Aberrations
    Useful deficiency
     
    hide Transgenic Constructs & Insertions
    Transgenic Constructs
    Type of construct
    Name
    Expression data
    UAS construct
    P{UAS-DsRed2-mir-2b-2}
    NA
    P{UAS-DsRed2-mir-2}
    NA
    P{UAS-mir-2.L}
    NA
    Insertions
    Type of insertions
    Name
    Expression data
    hide Related Comments
    Please look at the allele reports for the complete phenotype data
    hide Gene Ontology: Function, Process & Cellular Component ( 1 )
    hide Molecular Function
    CV term
    Evidence
    References
    hide Biological Process
    CV term
    Evidence
    References
    negative regulation of translational initiation
    inferred from direct assay
    (Thermann and Hentze, 2007)
    hide Cellular Component
    CV term
    Evidence
    References
    hide Sequence Ontology: Class of Gene
    miRNA_gene
    (Lagos-Quintana et al., 2001)
    nuclear_gene
    (Lagos-Quintana et al., 2001)
    hide Interactions & Pathways
    hide Summary of Genetic Interactions
    Interacts with
    Please look at the allele data for full details of the genetic interactions
    mir-2b-2 allele
    Gene
    References
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    Linkouts
    BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions
    •
    hide Orthologs
    Genome-wide drosophilid orthologs
    Curated drosophilid orthologs
     
    Linkouts
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    Produces phenotype in
    Produces NO phenotype in
    hide Stocks & Reagents
    hide Stocks Listed in FlyBase ( 0 )
    hide Genomic Clones ( 2 )
    hide cDNA Clones ( 0 )
    cDNA Clones, Fully Sequenced
    BDGP DGC clones
    Other clones
    cDNA Clones, End Sequenced (ESTs)
    BDGP DGC clones
    Other clones
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    Affy Oligo
    Linkouts
    GenomeRNAi - RNAi phenotypes (Heidelberg): high-throughput cell culture data
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    Source for database identity of
    Source for database merge of
    Additional comments
    hide Comments About Role
    hide Comments About Molecular Function
    mir-2a-1, mir-2a-2 and mir-2b-2 sequences are clustered within 400bp in 37E3-38A2.
    (Sempere et al., 2003)
    "mir-2" inhibits translation initiation without affecting mRNA stability.
    (Thermann and Hentze, 2007)
    hide Other Comments
    New annotation (CR32964) in release 3 of the genome annotation.
    (FlyBase Genome Annotators, 2002-2003)
    hide External Crossreferences & Linkouts
    Sequence Crossreferences
    RefSeq (Transcripts)
    •
    DDBJ / EMBL / GenBank
    •
    Other Crossreferences
    miRBase - the home of microRNA data
    •
    Linkouts
    BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions
    •
    FLIGHT - Cell culture data for RNAi and other high-throughput technologies
    •
    FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans
    •
    GenomeRNAi - RNAi phenotypes (Heidelberg): high-throughput cell culture data
    •
    hide Synonyms & Secondary IDs ( 9 )
    Reported As
    Symbol Synonym
    CR32964
     
    dme-mir-2b-2
    (Gesellchen and Boutros, 2004)
    miR-2
    (Carthew, 2006, Landthaler et al., 2004, He and Hannon, 2004, Bartel, 2004, Grosshans and Slack, 2002, Sempere et al., 2003)
    miR2
    (Thermann and Hentze, 2007)
    miR-2b
    (Alvarez-Garcia, 2005, Okamura et al., 2004, Gesellchen and Boutros, 2004, Boutla et al., 2003, Lai, 2003, Carthew, 2002, Ishizuka et al., 2002, Lee et al., 2001, Lagos-Quintana et al., 2001, Stark et al., 2003, Stark et al., 2003, Stark et al., 2005, Behura, 2007)
    mir-2b
    (Stark et al., 2003, Sempere et al., 2003)
    miR2b
    (Caudy et al., 2002, Thermann and Hentze, 2007)
    miR-2b-2
    (Brennecke, 2005.7.3, Brennecke, 2005, Lai et al., 2003, Lai, 2002)
    mir-2b-2
     
    Name Synonym
    mir-2b-2
     
    Secondary FlyBase IDs
      hide References ( 30 )
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      hide Recent research papers ( 1 )
      Thermann and Hentze, 2007, Nature 447(7146): 875--878
      Drosophila miR2 induces pseudo-polysomes and inhibits translation initiation. [FBrf0202080]
      Show all research papers ...
      hide Recent reviews ( 2 )
      Behura, 2007, Insect Biochem. Molec. Biol. 37(1): 3--9
      Insect microRNAs: Structure, function and evolution. [FBrf0194885]
      Carthew, 2006, Curr. Opin. Genet. Dev. 16(2): 203--208
      [title not yet available] [FBrf0191600]
      Show all reviews ...