A Database of Drosophila Genes & Genomes

 

Gene Dmel\mir-7

General Information
SymbolDmel\mir-7SpeciesD. melanogaster
Namemir-7Annotation symbolCR33042
Feature typemiRNA_geneFlyBase IDFBgn0046816
Created / Updated2003-12-01/2003-12-01
Genomic Location
Chromosome (arm)2RRecombination map
Cytogenetic map 57A7-57A7 Sequence location2R:16,493,586..16,493,608 [+]
Map ( GBrowse ) detailed view
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Automatically generated summary

See sections below for more information
This gene is referred to in FlyBase by the symbol mir-7 (CR33042, FBgn0046816). It has the cytological map location 57A7. Its sequence location is 2R:16493586..16493608. Its molecular function is unknown. It is involved in the biological processes: compound eye development; epidermal growth factor receptor signaling pathway; compound eye photoreceptor cell differentiation. 5 alleles are reported. The phenotypes of these alleles are annotated with: wing; 1st posterior cell; ommatidium; interommatidial bristle; photoreceptor cell R7. It has one annotated transcript.

hide Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
57A7-57A7  
Limits computationally determined from genome sequence between P{EP}l(2)05510EP2587&P{lacW}rigk07917 and P{lacW}l(2)k02206k02206  
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Molecular Map Data
Gene Order (in direction of increasing cytology)
References
Gene Order (overall orientation not stated)
References
hide Gene Model & Products
Please see the GBrowse view of Dmel\mir-7 for information on other features
detailed view FBtr0086220 FBtr0086221 FBtr0086219 FBtr0086222 FBtr0086256 FBtr0086255 FBpp0089363 FBpp0089365 FBpp0085537 FBpp0089364 FBpp0085567 FBpp0085568
Comments on Gene Model
hide Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
 
mir-7-RA
FBtr0086224
 NR_001897
  23
 
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
miRBase - the home of microRNA data
•
hide Sequences Consistent with the Gene Model
DDBJ /
EMBL /
GenBank
DNA sequence
 
Name
AJ421767
 
 
Maps to
Does NOT map to
Identified with
hide Mapped Features & Mutations
Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here
Type
Symbol & Location
Additional Notes
References
hide External Data
Linkouts
Crossreferences
hide Expression Data
FlyBase-Curated Data
Transcript data Please see the FlyBase Gene Expression Report for details of gene expression from the literature.
hide Summary of Transcript Expression
Stage
Tissue/Position
Reference
 embryonic stage-adult stage
 
(Sempere et al., 2003)
Marker for
    Subcellular Localization
    CV Term
    hide External Data & Images
    Linkouts
    FLIGHT - Cell culture data for RNAi and other high-throughput technologies
    •
    hide Alleles & Phenotypes
    hide Summary of Allele Phenotypes
    Other Phenotypes
    Allele
    visible, with Scer\GAL4dpp.blk1
    visible, with Scer\GAL4ptc-559.1
    Phenotype manifest in
    Allele
    wing, with Scer\GAL4ptc-559.1
    1st posterior cell, with Scer\GAL4ptc-559.1
    wing, with Scer\GAL4dpp.blk1
    1st posterior cell, with Scer\GAL4dpp.blk1
    ommatidium, with Scer\GAL4GMR.PF
    interommatidial bristle, with Scer\GAL4GMR.PF
    photoreceptor cell R7 | ectopic, with Scer\GAL4GMR.PF
    hide Classical Alleles ( 1 )
    For All Classical Alleles Show

    Allele of mir-7ClassMutagenStocksKnown lesion
    mir-7EP954
      		0 Yes
      hide Alleles Carried on Transgenic Constructs ( 4 )
      For All Alleles Carried on Transgenic Constructs Show

      Allele of mir-7ClassMutagenStocksKnown lesion
      mir-7Scer\UAS.T:Disc\RFP-DsRed20 Yes
      mir-7Scer\UAS.cLa0 Yes
      mir-7Scer\UAS.cLb0 Yes
      mir-7αTub84B.PS0 Yes
      hide Aneuploid Aberrations
      Useful deficiency
       
      Useful duplication
       
      Disrupted in
      (Li and Carthew, 2005)
      hide Transgenic Constructs & Insertions
      Transgenic Constructs
      Type of construct
      Name
      Expression data
      UAS construct
      P{UAS-DsRed2-mir-7}
      NA
      P{UAS-mir-7.L}
      NA
      Insertions
      Type of insertions
      Name
      Expression data
      insertion of mobile activating element
      P{EP}blEP954
      NA
      hide Related Comments
      Please look at the allele reports for the complete phenotype data
      hide Gene Ontology: Function, Process & Cellular Component ( 3 )
      hide Molecular Function
      CV term
      Evidence
      References
      hide Biological Process
      CV term
      Evidence
      References
      compound eye development
      inferred from mutant phenotype
      (Li and Carthew, 2005)
      compound eye photoreceptor cell differentiation
      inferred from mutant phenotype
      (Li and Carthew, 2005)
      epidermal growth factor receptor signaling pathway
      inferred from mutant phenotype
      (Li and Carthew, 2005)
      hide Cellular Component
      CV term
      Evidence
      References
      hide Sequence Ontology: Class of Gene
      miRNA_gene
      (Lagos-Quintana et al., 2001)
      nuclear_gene
      (Lagos-Quintana et al., 2001)
      hide Interactions & Pathways
      hide Summary of Genetic Interactions
      Interacts with
      Please look at the allele data for full details of the genetic interactions
      mir-7 allele
      Gene
      References
      unspecified
      Egfr
      (Li and Carthew, 2005)
      aop
      (Li and Carthew, 2005)
      hide External Data
      Linkouts
      BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions
      •
      hide Orthologs
      Genome-wide drosophilid orthologs
      Curated drosophilid orthologs
       
      Linkouts
      hide Functional Complementation between Species
      hide Inter-Species Misexpression Data
      Produces phenotype in
      Produces NO phenotype in
      hide Stocks & Reagents
      hide Stocks Listed in FlyBase ( 1 )
      Szeged
      -
      P{EP}blEP954
      hide Genomic Clones ( 2 )
      hide cDNA Clones ( 0 )
      cDNA Clones, Fully Sequenced
      BDGP DGC clones
      Other clones
      cDNA Clones, End Sequenced (ESTs)
      BDGP DGC clones
      Other clones
      hide RNAi & Array Information
      Affy Oligo
      Linkouts
      GenomeRNAi - RNAi phenotypes (Heidelberg): high-throughput cell culture data
      •
      hide Other Information
      hide Discoverer
      hide Etymology
      hide Identification
      hide Position Effect Variegation Data
      hide Relationship to Other Genes
      Source for database identity of
      Source for database merge of
      Additional comments
      hide Comments About Role
      hide Comments About Molecular Function
      There is reciprocal negative regulation between mir-7 and aop in retinal cells.
      (Li and Carthew, 2005)
      mir-7 transcription may be induced by Egfr through degradation of aop protein.
      (Li and Carthew, 2005)
      hide Other Comments
      New annotation (CR33042) in release 3 of the genome annotation.
      (FlyBase Genome Annotators, 2002-2003)
      hide External Crossreferences & Linkouts
      Sequence Crossreferences
      RefSeq (Transcripts)
      •
      DDBJ / EMBL / GenBank
      •
      Other Crossreferences
      miRBase - the home of microRNA data
      •
      Linkouts
      BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions
      •
      FLIGHT - Cell culture data for RNAi and other high-throughput technologies
      •
      FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans
      •
      GenomeRNAi - RNAi phenotypes (Heidelberg): high-throughput cell culture data
      •
      hide Synonyms & Secondary IDs ( 5 )
      Reported As
      Symbol Synonym
      CR33042
       
      dme-mir-7
      (Gesellchen and Boutros, 2004)
      miR-7
      (Leaman, 2005, Carthew, 2006, Alvarez-Garcia, 2005, Aboobaker et al., 2005, Miska, 2005, Wienholds, 2005, Forstemann et al., 2005, Lai et al., 2005, Brennecke, 2005, Nakahara and Carthew, 2004, Gesellchen and Boutros, 2004, Boutla et al., 2003, Lai et al., 2003, Lai, 2003, Bartel, 2004, Stark et al., 2003, Grosshans and Slack, 2002, Sempere et al., 2003, Lai, 2002, Lee et al., 2001, Lagos-Quintana et al., 2001, Stark et al., 2003, Stark et al., 2003, Reynolds, 2007, Li and Carthew, 2005, Stark et al., 2005, Nurminsky, 2007, Behura, 2007)
      Mir-7
      (Robins et al., 2005)
      mir-7
      (Garcia et al., 2007)
      Name Synonym
      mir-7
       
      Secondary FlyBase IDs
        hide References ( 35 )
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        hide Recent research papers (0)
        All research papers listed in FlyBase were published before 2006
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        hide Recent reviews ( 2 )
        Behura, 2007, Insect Biochem. Molec. Biol. 37(1): 3--9
        Insect microRNAs: Structure, function and evolution. [FBrf0194885]
        Carthew, 2006, Curr. Opin. Genet. Dev. 16(2): 203--208
        [title not yet available] [FBrf0191600]
        Show all reviews ...