Gene Dmel\Ilp1

Help

Close All Open All

General Information

Symbol

Dmel\Ilp1

Species

D. melanogaster

Name

Ilp1

Annotation symbol

CG14173

Feature type

protein_coding_gene

FlyBase ID

FBgn0044051

Created / Updated

2003-12-01/2003-12-01

Genomic Location

Chromosome (arm)

Recombination map

Cytogenetic map

67C8-67C8

Sequence location

3L:9,791,534..9,791,998 [+]

Map ( GBrowse )

Summary Information

Automatically generated summary

See sections below for more information

This gene is referred to in FlyBase by the symbol Ilp1 (CG14173, FBgn0044051). It has the cytological map location 67C8. Its sequence location is 3L:9791534..9791998. Its molecular function is described as: insulin receptor binding; hormone activity. It is involved in the biological process insulin receptor signaling pathway. 2 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide.

Detailed Mapping Data

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

67C8-67C8

Limits computationally determined from genome sequence between P{PZ}fry⁰²²⁴⁰ and P{lacW}l(3)L0539^L0539&P{PZ}Dhh1^rL562

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

Left of (cM)

Right of (cM)

Notes

Molecular Map Data

Gene Order (in direction of increasing cytology)

References

Gene Order (overall orientation not stated)

References

Overall orientation not stated: Ilp1+ Ilp2+ Ilp3- Ilp4- CG32052? Ilp5-

(Brogiolo et al., 2001)

Gene Model & Products

Please see the GBrowse view of Dmel\Ilp1 for information on other features

Comments on Gene Model

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Associated CDS (aa)

Ilp1-RA

FBtr0076328

NM_140102

465

154

Additional Transcript Data & Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kD)

Length (aa)

Theoretical pI

RefSeq ID

GenBank protein

Ilp1-PA

FBpp0076057

16.9

154

6.13

NP_648359

AAF50205

Additional Polypeptide Data & Comments

Reported size (kD)

Comments

External Data

Linkouts

Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

Insulin/IGF/relaxin (IPR004825)

Insulin-like (IPR016179)

Sequences Consistent with the Gene Model

DDBJ /
EMBL /
GenBank

DNA sequence

Protein sequence

Name

AE003550

AAF50205

UniProtKB/Swiss-Prot

Q9VT50

UniProtKB/TrEMBL

Maps to

Does NOT map to

Identified with

Mapped Features & Mutations

Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here

Type

Symbol & Location

Additional Notes

References

External Data

Linkouts

DEDB - Drosophila exon database: splicing graphs

•

4598

Crossreferences

Expression Data

FlyBase-Curated Data

Transcript and
Protein data

Please see the FlyBase Gene Expression Report for details of gene expression from the literature.

Summary of Transcript Expression

Stage

Tissue/Position

Reference

Marker for

Subcellular Localization

CV Term

Summary of Polypeptide Expression

Stage

Tissue/Position

Reference

Marker for

Subcellular Localization

CV Term

External Data & Images

Linkouts

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0044051

Alleles & Phenotypes

Summary of Allele Phenotypes

Phenotype manifest in

Allele

Classical Alleles ( 0 )

For All Classical Alleles Show

Allele of Ilp1	Class	Mutagen	Stocks	Known lesion

Alleles Carried on Transgenic Constructs ( 2 )

For All Alleles Carried on Transgenic Constructs Show

Allele of Ilp1	Class	Mutagen	Stocks	Known lesion
Ilp1^GD2398		in vitro construct \| RNAi in vitro construct \| regulatory fusion	1	Yes
Ilp1^Scer\UAS.cIa		in vitro construct \| regulatory fusion	0	Yes

Aneuploid Aberrations

Useful deficiency

Df(3L)AC1

Useful duplication

Dp(3;3)M67C⁺7

Disrupted in

Df(3L)AC1

(Brogiolo et al., 2001)

Transgenic Constructs & Insertions

Transgenic Constructs

Type of construct

Name

Expression data

UAS construct

P{GD2398}

P{UAS-Ilp1.I}

Insertions

Type of insertions

Name

Expression data

Related Comments

Please look at the allele reports for the complete phenotype data

Gene Ontology: Function, Process & Cellular Component ( 4 )

Molecular Function

CV term

Evidence

References

hormone activity

inferred from electronic annotation with InterPro:IPR004825, InterPro:IPR016179

(FlyBase Curators et al., 2004-)

insulin receptor binding

inferred from sequence or structural similarity

(Swiss-Prot Project Members, 2000.10.1)

inferred from sequence or structural similarity with HGNC_gene:INS; HGNC:6081; OMIM:176730

(Brogiolo et al., 2001)

Biological Process

CV term

Evidence

References

insulin receptor signaling pathway

inferred from sequence or structural similarity with HGNC_gene:INS; HGNC:6081; OMIM:176730

(Brogiolo et al., 2001)

Cellular Component

CV term

Evidence

References

extracellular region

inferred from sequence or structural similarity with HGNC_gene:INS; HGNC:6081; OMIM:176730

(Brogiolo et al., 2001)

Sequence Ontology: Class of Gene

protein_coding_gene

nuclear_gene

Interactions & Pathways

Summary of Genetic Interactions

Interacts with

Please look at the allele data for full details of the genetic interactions

Ilp1 allele

Gene

References

External Data

Linkouts

BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions

•

64537

Orthologs

Genome-wide drosophilid orthologs

Dana\GF24677

Dere\GG15411

Dgri\GH15431

Dmoj\GI13033

Dper\GL16295

Dpse\GA12803

Dsec\GM25185

Dsim\GD14217

Dvir\GJ12128

Dwil\GK10979

Dyak\GE21719

Curated drosophilid orthologs

Dpse\GA12803

Linkouts

Functional Complementation between Species

Inter-Species Misexpression Data

Produces phenotype in

Produces NO phenotype in

Stocks & Reagents

Stocks Listed in FlyBase ( 1 )

VDRC

v5198

w¹¹¹⁸; P{GD2398}v5198/TM3

Genomic Clones ( 2 )

cDNA Clones ( 0 )

Please Note

This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA Clones, Fully Sequenced

BDGP DGC clones

Other clones

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi & Array Information

Affy Oligo

Linkouts

DRSC - RNAi screening (Harvard): high-throughput cell culture data and design

•

FBgn0044051

Antibody Information

Other Information

Discoverer

Etymology

Identification

Position Effect Variegation Data

Relationship to Other Genes

Source for database identity of

Source for database merge of

Source for merge of: Ilp1 CG14173

(Brogiolo et al., 2001)

Additional comments

Comments About Role

Comments About Molecular Function

Other Comments

May be a pseudogene.

(Brogiolo et al., 2001)

External Crossreferences & Linkouts

Sequence Crossreferences

RefSeq (Transcripts)

•

NM_140102

RefSeq (Proteins)

•

NP_648359

DDBJ / EMBL / GenBank

•

UniProtKB/Swiss-Prot

•

Q9VT50

Other Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

Insulin/IGF/relaxin (IPR004825)

Insulin-like (IPR016179)

Linkouts

BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions

•

64537

DEDB - Drosophila exon database: splicing graphs

•

4598

DRSC - RNAi screening (Harvard): high-throughput cell culture data and design

•

FBgn0044051

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0044051

FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans

•

FBgn0044051

Synonyms & Secondary IDs ( 14 )

Reported As

Symbol Synonym

CG14173

(Brogiolo et al., 2001, )

dilp

(Wu et al., 2005, Belawat and Hafen, 2005)

DILP

(Wu et al., 2005, Nijhout, 2003, Nijhout, 2003)

Dilp

(Bradley and Leevers, 2003, Rhea et al., 2007, Ahrens et al., 2007)

dilp-1

(Hwangbo et al., 2004)

dilp1

(Tatar et al., 2003, Ikeya et al., 2002, Rulifson et al., 2002, Brogiolo et al., 2001, Flatt et al., 2005, Libert, 2007, Melcher and Pankratz, 2005)

Dilp 1

(Claeys et al., 2002)

DILP1

(Leevers, 2001)

Dilp-1

(Hoshizaki and Gibbs, 2007)

Ilp

(Edgar, 2006)

Ilp1

(FlyBase Curators et al., 2004-)

unnamed

(vanden Broeck, 2001)

Name Synonym

Drosophila insulin-like peptide 1

(Oldham and Hafen, 2003)

Ilp1

insulin-like peptide

(Flatt et al., 2005)

Secondary FlyBase IDs

FBgn0036045

References ( 26 )

Generate a list of

All references relating to this gene ( 26 )

List References by type

Recent research papers ( 1 )

Ahrens et al., 2007, Fly 1(3): 182--186: A proteome catalog of Drosophila melanogaster: an essential resource for targeted quantitative proteomics. [FBrf0200101]

Show all research papers ...

Recent reviews ( 1 )

Edgar, 2006, Nature Rev. Genet. 7(12): 907--916: How flies get their size: genetics meets physiology. [FBrf0193088]

Show all reviews ...