A Database of Drosophila Genes & Genomes

FB2008_07, released August 8, 2008
 

Gene Dmel\CG18854

General Information
SymbolDmel\CG18854SpeciesD. melanogaster
NameCG18854Annotation symbolCG18854
Feature typeprotein_coding_geneFlyBase IDFBgn0042174
Created / Updated2003-12-01/2003-12-01
Genomic Location
Chromosome (arm)2LRecombination map
Cytogenetic map30D1-30D1Sequence location2L:9,787,279..9,790,745 [-]
Map ( GBrowse ) detailed view
hide Summary Information
Automatically generated summary

See sections below for more information
This gene is referred to in FlyBase by the symbol CG18854 (FBgn0042174). It has the cytological map location 30D1. Its sequence location is 2L:9787279..9790745. Its molecular function is described as inositol trisphosphate 3-kinase activity. The biological processes in which it is involved are not known. 2 alleles are reported. No phenotypic data is available. It has 3 annotated transcripts and 3 annotated polypeptides.

hide Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
30D1-30D1  
Limits computationally determined from genome sequence between P{lacW}zf30Ck02506&P{EP}undEP424 and P{lacW}l(2)k06416k06416&P{lacW}sopk04603  
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
30D-30D
 
(Gray, 2000.3.23)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Molecular Map Data
Gene Order (in direction of increasing cytology)
References
Gene Order (overall orientation not stated)
References
hide Gene Model & Products
Please see the GBrowse view of Dmel\CG18854 for information on other features
detailed view FBtr0079869 FBtr0079920 FBtr0079919 FBtr0079918 FBtr0079870 FBtr0079917 FBpp0079465 FBpp0079510 FBpp0079508 FBpp0079509 FBpp0079466 FBpp0079507 FBti0023398 FBti0026334 FBti0023496 FBti0024073
Comments on Gene Model
Probable pseudogene: Extensive EST data support transcript of ~1.5kb; but, longest ORF is 93 amino acids. Multiple alternative transcripts are represented by the EST data; longest ORF less than 150 amino acids.
hide Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Associated CDS (aa)
CG18854-RA
FBtr0079918
 NM_164872
  2579
  93
CG18854-RB
FBtr0079920
 NM_164873
  2572
  93
CG18854-RC
FBtr0079919
 NM_144442
  2514
  120
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
hide Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kD)
Length (aa)
Theoretical pI
RefSeq ID
GenBank protein
CG18854-PA  
FBpp0079508  
10.3  
93  
3.92  
  NP_723489
  AAG22425
CG18854-PB  
FBpp0079510  
10.3  
93  
3.92  
  NP_723490
  AAF52814
CG18854-PC  
FBpp0079509  
13.7  
120  
5.06  
  NP_652699
  AAN10708
Additional Polypeptide Data & Comments
Reported size (kD)
Comments
External Data
Linkouts
PANTHER - Protein classification by function, families, and pathways
•
Crossreferences
hide Sequences Consistent with the Gene Model
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
AA567562
 
AA568025
 
AA696542
 
AA697345
 
AA697376
 
AA697538
 
AA697730
 
AA698139
 
AA801570
 
AA820395
 
AA949369
 
AA979599
 
AE003626
AAF52814
 
AE003626
AAG22425
 
AE003626
AAN10708
 
AF248501
 
AF248502
 
AI062925
 
AI238729
 
AI258835
 
AI296247
 
AI404006
 
AI404534
 
AI455412
 
AY061008
 
BF496615
 
BG636397
 
BI232973
 
BI372410
 
BI563919
 
BI567700
 
BI572338
 
BI583795
 
BI585813
 
BI587695
 
BI606459
 
BI617658
 
BI618517
 
BI620056
 
BI633346
 
BI634754
 
BI640239
 
BI640378
 
BT001425
AAN71180
 
BT001500
AAN71255
 
BT001500
AAN71255
 
BT021254
AAX33402
 
CK132530
 
CK660053
 
CK661417
 
CO153632
 
CO269578
 
CO302725
 
CO309873
 
CO310740
 
CO316403
 
CO322889
 
EC059855
 
EC064573
 
EC075153
 
EC202111
 
EC203998
 
EC223422
 
EC243570
 
EC246427
 
EC267309
 
LD23982
 
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
    Maps to
    Does NOT map to
    Identified with
    (BDGP Project Members, 2000-)
    (Monnier et al., 2002)
    hide Mapped Features & Mutations
    Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here
    Type
    Symbol & Location
    Additional Notes
    References
    hide External Data
    Linkouts
    DEDB - Drosophila exon database: splicing graphs
    •
    Crossreferences
    hide Expression Data
    FlyBase-Curated Data
    Transcript and
    Protein data     		Please see the FlyBase Gene Expression Report for details of gene expression from the literature.
    hide Summary of Transcript Expression
    Stage
    Tissue/Position
    Reference
    Marker for
      Subcellular Localization
      CV Term
      hide Summary of Polypeptide Expression
      Stage
      Tissue/Position
      Reference
      Marker for
        Subcellular Localization
        CV Term
        hide External Data & Images
        Linkouts
        FLIGHT - Cell culture data for RNAi and other high-throughput technologies
        •
        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
        •
        GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies
        •
        BDGP expression data
        •
        Show all BDGP original images, annotations and embryonic microarray data for CG18854
        FlyExpress - Embryonic expression images (BDGP data)
        •
        Show all FlyExpress processed images for CG18854
        hide Alleles & Phenotypes
        hide Summary of Allele Phenotypes
        Phenotype manifest in
        Allele
        hide Classical Alleles ( 2 )
        For All Classical Alleles Show

        Allele of CG18854ClassMutagenStocksKnown lesion
        CG18854EY00141
          		0 --
          CG18854KG05849
            		0 --
            hide Alleles Carried on Transgenic Constructs ( 0 )
            For All Alleles Carried on Transgenic Constructs Show

            Allele of CG18854ClassMutagenStocksKnown lesion
            hide Aneuploid Aberrations
            Useful deficiency
             
            Disrupted in
            (Ryder, 2004.4.26)
            hide Transgenic Constructs & Insertions
            Transgenic Constructs
            Type of construct
            Name
            Expression data
            UAS construct
            P{GD11193}
            NA
            P{GD8628}
            NA
            Insertions
            Type of insertions
            Name
            Expression data
            miscellaneous insertions
            P{SUPor-P}CG18854KG05849
            NA
            insertion of mobile activating element
            P{EPgy2}CG18854EY00141
            NA
            hide Related Comments
            Please look at the allele reports for the complete phenotype data
            hide Gene Ontology: Function, Process & Cellular Component ( 1 )
            hide Molecular Function
            CV term
            Evidence
            References
            inositol trisphosphate 3-kinase activity
            non-traceable author statement
            (Gray, 2000.3.23)
            inferred from sequence or structural similarity with UniProtKB:P17105
            (FlyBase, 1992-)
            hide Biological Process
            CV term
            Evidence
            References
            hide Cellular Component
            CV term
            Evidence
            References
            hide Sequence Ontology: Class of Gene
            protein_coding_gene
             
            nuclear_gene
             
            hide Interactions & Pathways
            hide Summary of Genetic Interactions
            Interacts with
            Please look at the allele data for full details of the genetic interactions
            CG18854 allele
            Gene
            References
            hide External Data
            Linkouts
            BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions
            •
            hide Orthologs
            Genome-wide drosophilid orthologs
            Curated drosophilid orthologs
            Linkouts
            hide Functional Complementation between Species
            hide Inter-Species Misexpression Data
            Produces phenotype in
            Produces NO phenotype in
            hide Stocks & Reagents
            hide Stocks Listed in FlyBase ( 2 )
            Bloomington
            14810
            y1 w67c23; P{EPgy2}EY00141
            14127
            y1 w67c23; P{SUPor-P}KG05849
            hide Genomic Clones ( 2 )
            hide cDNA Clones ( 47 )
            Please Note
            This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
            cDNA Clones, Fully Sequenced
            BDGP DGC clones
            Other clones
            cDNA Clones, End Sequenced (ESTs)
            BDGP DGC clones
            Other clones
            hide RNAi & Array Information
            Affy Oligo
            Linkouts
            DRSC - RNAi screening (Harvard): high-throughput cell culture data and design
            •
            GenomeRNAi - RNAi phenotypes (Heidelberg): high-throughput cell culture data
            •
            hide Antibody Information
            hide Other Information
            hide Discoverer
            hide Etymology
            hide Identification
            hide Position Effect Variegation Data
            hide Relationship to Other Genes
            Source for database identity of
            Source for database merge of
            Source for merge of: CG18854 CG13122 Source for merge of CG18854 CG13122 was a shared cDNA (date:010720).
            (FlyBase, 1996-)
            Additional comments
            hide Comments About Role
            hide Comments About Molecular Function
            The Hrp59 protein binds preferentially to a subset of mRNAs, including CG18854 mRNA.
            (Kiesler et al., 2005)
            hide Other Comments
            hide External Crossreferences & Linkouts
            Sequence Crossreferences
            RefSeq (Transcripts)
            •
            RefSeq (Proteins)
            •
            DDBJ / EMBL / GenBank
            •
            UniProtKB/TrEMBL
            •
            Other Crossreferences
            Linkouts
            BDGP expression data
            •
            Show all BDGP original images, annotations and embryonic microarray data for CG18854
            BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions
            •
            DEDB - Drosophila exon database: splicing graphs
            •
            DRSC - RNAi screening (Harvard): high-throughput cell culture data and design
            •
            FLIGHT - Cell culture data for RNAi and other high-throughput technologies
            •
            FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
            •
            FlyExpress - Embryonic expression images (BDGP data)
            •
            FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans
            •
            GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies
            •
            GenomeRNAi - RNAi phenotypes (Heidelberg): high-throughput cell culture data
            •
            PANTHER - Protein classification by function, families, and pathways
            •
            hide Synonyms & Secondary IDs ( 2 )
            Reported As
            Symbol Synonym
            CG13122
            (Egger et al., 2002, Tricoire, 2001.3.6, )
            CG18854
            (Kiesler et al., 2005)
            Name Synonym
            CG18854
             
            Secondary FlyBase IDs
            • FBgn0032148
            hide References ( 12 )
            Research paper
            Kiesler et al., 2005, J. Cell Biol. 168(7): 1013--1025
            Hrp59, an hnRNP M protein in Chironomus and Drosophila, binds to exonic splicing enhancers and is required for expression of a subset of mRNAs. [FBrf0184063]
            Egger et al., 2002, Development 129(14): 3295--3309
            Gliogenesis in Drosophila: genome-wide analysis of downstream genes of glial cells missing in the embryonic nervous system. [FBrf0151258]
            Monnier et al., 2002, Free Radical Biol. Med. 33(9): 1250--1259
            Control of oxidative stress resistance by IP3 kinase in Drosophila melanogaster. [FBrf0151984]
            Supplementary material
            Giot et al., 2003, Science 302(5651):
            Tables S1 to S7. [FBrf0166452]
            Personal communication to FlyBase
            Ryder, 2004.4.26, Exelixis CG deletion data.
            Exelixis CG deletion data. [FBrf0184335]
            Tricoire, 2001.3.6, Helping FlyBase: ADRC-10741.
            Helping FlyBase: ADRC-10741. [FBrf0135313]
            FlyBase analysis
            Curators, 2008, Insertion identifiers and alleles based on genomic location of insertions with respect to gene annotations.
            Insertion identifiers and alleles based on genomic location of insertions with respect to gene annotations. [FBrf0202955]
            FlyBase, 1996-, FlyBase inference based on genome sequence analysis.
            FlyBase inference based on genome sequence analysis. [FBrf0104946]
            FlyBase, 1992-, FlyBase curation
            FlyBase curation. [FBrf0105495]
            DNA/RNA sequence record
            Gray, 2000.3.23, GenBank/EMBL/DDBJ: AF248501
            Drosophila melanogaster 1,4,5-trisphosphate 3-kinase-like mRNA, complete sequence. [FBrf0145347]
            Computer file
            Gene Disruption Project members, 2001-, [title not yet available]
            [title not yet available] [FBrf0132177]
            BDGP Project Members, 2000-, Berkeley Drosophila Genome Project.
            Berkeley Drosophila Genome Project. [FBrf0125078]