A Database of Drosophila Genes & Genomes

FB2008_07, released August 8, 2008
 

Gene Dmel\Or19a

General Information
SymbolDmel\Or19aSpeciesD. melanogaster
NameOdorant receptor 19aAnnotation symbolCG18859
Feature typeprotein_coding_geneFlyBase IDFBgn0041626
Created / Updated2003-12-01/2003-12-01
Genomic Location
Chromosome (arm)XRecombination map
Cytogenetic map19B3-19B3Sequence locationX:20,035,852..20,037,221 [-]
Map ( GBrowse ) detailed view
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Automatically generated summary

See sections below for more information
The gene Odorant receptor 19a is referred to in FlyBase by the symbol Or19a (CG18859, FBgn0041626). It has the cytological map location 19B3. Its sequence location is X:20035852..20037221. Its molecular function is described as: olfactory receptor activity; odorant binding. It is involved in the biological process sensory perception of smell. One allele is reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide.
hide Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
19B3-19B3  
Limits computationally determined from genome sequence between P{EP}amnEP1639&P{EP}amnEP367 and P{EP}CG1702EP1525  
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Molecular Map Data
Gene Order (in direction of increasing cytology)
References
Gene Order (overall orientation not stated)
References
hide Gene Model & Products
Please see the GBrowse view of Dmel\Or19a for information on other features
detailed view FBtr0112534 FBtr0070029 FBpp0111446 FBpp0070028 FBti0058013
Comments on Gene Model
hide Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Associated CDS (aa)
Or19a-RB
FBtr0070029
 NM_080274
  1164
  387
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
hide Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kD)
Length (aa)
Theoretical pI
RefSeq ID
GenBank protein
Or19a-PB  
FBpp0070028  
44.2  
387  
9.38  
  NP_525013
  AAG22450
Additional Polypeptide Data & Comments
Reported size (kD)
Comments
External Data
Linkouts
PANTHER - Protein classification by function, families, and pathways
•
Crossreferences
InterPro domains - A database of protein families, domains, and functional sites
•
Olfactory receptor, Drosophila (IPR004117)
hide Sequences Consistent with the Gene Model
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
AE002611
AAG22450
 
EY198783
 
 
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL
    Maps to
    Does NOT map to
    Identified with
    hide Mapped Features & Mutations
    Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here
    Type
    Symbol & Location
    Additional Notes
    References
    hide External Data
    Linkouts
    DEDB - Drosophila exon database: splicing graphs
    •
    Crossreferences
    hide Expression Data
    FlyBase-Curated Data
    Transcript and
    Protein data     		Please see the FlyBase Gene Expression Report for details of gene expression from the literature.
    hide Summary of Transcript Expression
    Stage
    Tissue/Position
    Reference
    Marker for
      Subcellular Localization
      CV Term
      hide Summary of Polypeptide Expression
      Stage
      Tissue/Position
      Reference
      Marker for
        Subcellular Localization
        CV Term
        hide External Data & Images
        Linkouts
        FLIGHT - Cell culture data for RNAi and other high-throughput technologies
        •
        hide Alleles & Phenotypes
        hide Summary of Allele Phenotypes
        Phenotype manifest in
        Allele
        hide Classical Alleles ( 0 )
        For All Classical Alleles Show

        Allele of Or19aClassMutagenStocksKnown lesion
        hide Alleles Carried on Transgenic Constructs ( 1 )
        For All Alleles Carried on Transgenic Constructs Show

        Allele of Or19aClassMutagenStocksKnown lesion
        Or19aScer\UAS.T:Hsap\MYC0 Yes
        hide Aneuploid Aberrations
        Useful deficiency
         
        Useful duplication
         
        hide Transgenic Constructs & Insertions
        Transgenic Constructs
        Type of construct
        Name
        Expression data
        UAS construct
        P{GD17406}
        NA
        P{GD17658}
        NA
        P{GD734}
        NA
        P{UAS-Or19a.MYC}
        NA
        Insertions
        Type of insertions
        Name
        Expression data
        hide Related Comments
        Please look at the allele reports for the complete phenotype data
        hide Gene Ontology: Function, Process & Cellular Component ( 5 )
        hide Molecular Function
        CV term
        Evidence
        References
        odorant binding
        inferred from electronic annotation with InterPro:IPR004117
        (FlyBase Curators et al., 2004-)
        olfactory receptor activity
        inferred from sequence or structural similarity
        (Robertson, 2000.10.17)
        inferred from sequence or structural similarity
        (Swiss-Prot Project Members, 2000.10.1)
        inferred from direct assay
        (Hallem and Carlson, 2006)
        hide Biological Process
        CV term
        Evidence
        References
        sensory perception of smell
        inferred from sequence or structural similarity
        (Robertson, 2000.10.17)
        inferred from sequence or structural similarity
        (Swiss-Prot Project Members, 2000.10.1)
        inferred from electronic annotation with InterPro:IPR004117
        (FlyBase Curators et al., 2004-)
        hide Cellular Component
        CV term
        Evidence
        References
        integral to membrane
        inferred from sequence or structural similarity
        (Robertson, 2000.10.17)
        inferred from sequence or structural similarity
        (Swiss-Prot Project Members, 2000.10.1)
        membrane
        inferred from electronic annotation with InterPro:IPR004117
        (FlyBase Curators et al., 2004-)
        hide Sequence Ontology: Class of Gene
        protein_coding_gene
         
        nuclear_gene
         
        hide Interactions & Pathways
        hide Summary of Genetic Interactions
        Interacts with
        Please look at the allele data for full details of the genetic interactions
        Or19a allele
        Gene
        References
        hide External Data
        Linkouts
        BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions
        •
        hide Orthologs
        Genome-wide drosophilid orthologs
        Curated drosophilid orthologs
         
        Linkouts
        InParanoid orthologs - Eukaryotic orthologs
        •
        hide Functional Complementation between Species
        hide Inter-Species Misexpression Data
        Produces phenotype in
        Produces NO phenotype in
        hide Stocks & Reagents
        hide Stocks Listed in FlyBase ( 0 )
        hide Genomic Clones ( 1 )
        hide cDNA Clones ( 1 )
        Please Note
        This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
        cDNA Clones, Fully Sequenced
        BDGP DGC clones
        Other clones
        cDNA Clones, End Sequenced (ESTs)
        BDGP DGC clones
        Other clones
        hide RNAi & Array Information
        Affy Oligo
        Linkouts
        DRSC - RNAi screening (Harvard): high-throughput cell culture data and design
        •
        GenomeRNAi - RNAi phenotypes (Heidelberg): high-throughput cell culture data
        •
        hide Antibody Information
        hide Other Information
        hide Discoverer
        hide Etymology
        hide Identification
        hide Position Effect Variegation Data
        hide Relationship to Other Genes
        Source for database identity of
        Source for database merge of
        Source for merge of: Or19a CG18859
        (Robertson, 2000.10.17)
        Additional comments
        Source for split of: CG18859 Annotation CG18859 split into CG32824 and Or19a in release 3 of the genome annotation.
        (FlyBase Genome Annotators, 2002-2003)
        hide Comments About Role
        hide Comments About Molecular Function
        hide Other Comments
        hide External Crossreferences & Linkouts
        Sequence Crossreferences
        RefSeq (Transcripts)
        •
        RefSeq (Proteins)
        •
        DDBJ / EMBL / GenBank
        •
        UniProtKB/Swiss-Prot
        •
        Other Crossreferences
        InterPro domains - A database of protein families, domains, and functional sites
        •
        Olfactory receptor, Drosophila (IPR004117)
        Linkouts
        BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions
        •
        DEDB - Drosophila exon database: splicing graphs
        •
        DRSC - RNAi screening (Harvard): high-throughput cell culture data and design
        •
        FLIGHT - Cell culture data for RNAi and other high-throughput technologies
        •
        FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans
        •
        GenomeRNAi - RNAi phenotypes (Heidelberg): high-throughput cell culture data
        •
        InParanoid orthologs - Eukaryotic orthologs
        •
        PANTHER - Protein classification by function, families, and pathways
        •
        hide Synonyms & Secondary IDs ( 6 )
        Reported As
        Symbol Synonym
        19a
        (Vogt et al., 2002)
        19A.1
        (Warr and Vosshall, 2000.5.19)
        CG18859
        (Robertson, 2000.10.17, )
        DOR37
        (Warr and Vosshall, 2000.5.19)
        Or19a
        (Hallem and Carlson, 2006, Kreher et al., 2005, Reiter et al., 2007)
        Name Synonym
        Odorant receptor 19a
        (Warr and Vosshall, 2000.5.19)
        Secondary FlyBase IDs
        • FBgn0042176
        hide References ( 19 )
        Research paper
        Reiter et al., 2007, Fly 1(3): 164--171
        Accentuate the Negative. [FBrf0200136]
        Hallem and Carlson, 2006, Cell 125(1): 143--160
        Coding of odors by a receptor repertoire. [FBrf0189911]
        Couto et al., 2005, Curr. Biol. 15(17): 1535--1547
        Molecular, anatomical, and functional organization of the Drosophila olfactory system. [FBrf0187305]
        Fishilevich and Vosshall, 2005, Curr. Biol. 15(17): 1548--1553
        Genetic and functional subdivision of the Drosophila antennal lobe. [FBrf0187306]
        Kreher et al., 2005, Neuron 46(3): 445--456
        The molecular basis of odor coding in the Drosophila larva. [FBrf0188180]
        Hallem et al., 2004, Cell 117(7): 965--979
        The molecular basis of odor coding in the Drosophila antenna. [FBrf0179238]
        Robertson et al., 2003, Proc. Natl. Acad. Sci. USA 100(Supplement 2): 14537--14542
        Molecular evolution of the insect chemoreceptor gene superfamily in Drosophila melanogaster. [FBrf0168007]
        Vogt et al., 2002, J. exp. Biol. 205(6): 719--744
        A comparative study of odorant binding protein genes: differential expression of the PBP1-GOBP2 gene cluster in Manduca sexta (Lepidoptera) and the organization of OBP genes in Drosophila melanogaster (Diptera). [FBrf0147124]
        Vosshall et al., 2000, Cell 102(2): 147--159
        An olfactory sensory map in the fly brain. [FBrf0130146]
        Review
        Hallem and Carlson, 2004, Trends Genet. 20(9): 453--459
        The odor coding system of Drosophila. [FBrf0179899]
        Otaki and Yamamoto, 2003, J. Theor. Biol. 223(1): 27--37
        Length analyses of Drosophila odorant receptors. [FBrf0160830]
        Personal communication to FlyBase
        FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms.
        Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215]
        Robertson, 2002.7.5, More on Or19a duplication.
        More on Or19a duplication. [FBrf0150776]
        Robertson, 2001.5.16, FlyBase error report on Wed Mar 16 12:13:50 2001.
        FlyBase error report on Wed Mar 16 12:13:50 2001. [FBrf0136024]
        Robertson, 2000.10.17, FlyBase error report for CG18859 on Tue Oct 17 11:55:39 2000.
        FlyBase error report for CG18859 on Tue Oct 17 11:55:39 2000. [FBrf0131206]
        Warr and Vosshall, 2000.5.19, Odorant receptors.
        Odorant receptors. [FBrf0128191]
        FlyBase analysis
        FlyBase Genome Annotators, 2002-2003, Changes affecting gene model number or type in releases 3.0 and 3.1 of the annotated D.melanogaster genome.
        Changes affecting gene model number or type in releases 3.0 and 3.1 of the annotated D.melanogaster genome. [FBrf0148886]
        Protein sequence record
        Swiss-Prot Project Members, 2000.10.1, UniProtKB: Q9I816
        PUTATIVE ODORANT RECEPTOR 19A. [FBrf0136619]
        Letter
        Warr et al., 2000, Cell 102(2): 145--146
        A unified nomenclature system for the Drosophila odorant receptors. [FBrf0130157]