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Gene Dmel\bft

General Information
Symbol	Dmel\bft	Species	D. melanogaster
Name	bereft	Annotation symbol	CR31863
Feature type	non_protein_coding_gene	FlyBase ID	FBgn0041606
Created / Updated	2003-12-01/2003-12-01
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	33B2-33B3	Sequence location	2L:11,956,221..11,971,094 [-]
Map ( GBrowse )	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene bereft is referred to in FlyBase by the symbol bft (CR31863, FBgn0041606). It has the cytological map location 33B2-33B3. Its sequence location is 2L:11956221..11971094. Its molecular function is unknown. It is involved in the biological process bristle morphogenesis. 9 alleles are reported. The phenotypes of these alleles are annotated with: interommatidial bristle; orbital bristle; vertical bristle; postvertical bristle; humeral bristle; dorsocentral bristle; postalar bristle; scutellar bristle; sensillum trichodeum. It has 2 annotated transcripts.
External Summaries
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 33B2-33B3   Limits computationally determined from genome sequence between P{PZ}crol04418&P{EP}crolEP1183 and P{EP}MESK1EP980
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Molecular Map Data
Gene Order (in direction of increasing cytology) References Gene Order (overall orientation not stated) References
Gene Model & Products
Please see the GBrowse view of Dmel\bft for information on other features
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt)   bft-RA FBtr0080319  NR_001644   3428   bft-RB FBtr0080320  NR_001643   6576
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence   Name AF234639   AF234640   AF313801   AF486813   AI293558   CL705794   CZ478879
Maps to
Does NOT map to
Identified with
Mapped Features & Mutations
Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
FlyBase-Curated Data
Transcript data	Please see the FlyBase Gene Expression Report for details of gene expression from the literature.
Summary of Transcript Expression
Stage Tissue/Position Reference
Marker for
Subcellular Localization
CV Term
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0041606
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable bftEY04690 viable (with bft225) bft122 viable (with bft122) bft225 lethal (with Df(2L)esc-P3-0) bft97 lethal (with Df(2L)esc10) bft97 lethal (with Df(2L)prd1.7) bft122 bft24 lethal (with bft97) bft227 lethal (with bft227) bft97 lethal (with bft122) bft116 lethal (with bft116) bft122 lethal | recessive bft225 bft97 lethal | partially (with Df(2L)esc-P3-0) bft116 bft122 bft225 bft227 bft24 bft6 lethal | partially (with Df(2L)esc10) bft116 bft122 bft225 bft227 bft24 bft6 lethal | partially (with Df(2L)prd1.7) bft116 bft225 bft227 bft6 bft97 lethal | partially (with bft97) bft116 bft122 bft225 bft24 bft6 lethal | partially (with bft6) bft116 bft122 bft225 bft227 bft24 bft97 lethal | partially (with bft24) bft116 bft122 bft225 bft227 bft6 bft97 lethal | partially (with bft227) bft116 bft122 bft225 bft24 bft6 lethal | partially (with bft225) bft116 bft227 bft24 bft6 bft97 lethal | partially (with bft122) bft227 bft24 bft6 bft97 lethal | partially (with bft116) bft225 bft227 bft24 bft6 bft97 lethal | partially | recessive bft227 bft24 bft6 Sterility Allele fertile bftEY04690 Phenotype manifest in Allele interommatidial bristle bft116 bft122 bft225 bft227 bft24 bft6 interommatidial bristle (with bft6) bft116 bft225 bft227 bft24 bft97 interommatidial bristle (with bft24) bft116 bft225 bft227 bft6 bft97 interommatidial bristle (with bft97) bft116 bft122 bft225 bft24 bft6 interommatidial bristle (with bft225) bft116 bft24 bft6 bft97 interommatidial bristle (with bft227) bft116 bft24 bft6 interommatidial bristle (with Df(2L)esc10) bft116 bft122 bft24 bft6 interommatidial bristle (with Df(2L)esc-P3-0) bft116 bft227 bft24 bft6 interommatidial bristle (with Df(2L)prd1.7) bft116 bft225 bft227 bft6 bft97 interommatidial bristle (with bft116) bft225 bft227 bft24 bft6 bft97 orbital bristle bft225 bft24 bft6 vertical bristle bft225 bft24 bft6 postvertical bristle bft225 bft24 bft6 humeral bristle bft225 bft24 bft6 dorsocentral bristle bft225 bft24 bft6 scutellar bristle bft225 bft24 bft6 interommatidial bristle & socket bft225 bft24 sensillum trichodeum bft24 sensillum trichodeum & trichogen cell bft24 postalar bristle bft6 interommatidial bristle (with bft122) bft97
Classical Alleles ( 9 )
For All Classical Alleles Show
Allele of bft Class Mutagen Stocks Known lesion bft116 Δ2-3 0 -- bft122 Δ2-3 0 -- bft225 Δ2-3 0 -- bft227 Δ2-3 0 -- bft24 Δ2-3 0 Yes bft6 Δ2-3 0 Yes bft97 Δ2-3 0 -- bftEY04690 P-element activity 1 Yes bfte01057 piggyBac transposase 1 --
Alleles Carried on Transgenic Constructs ( 0 )
For All Alleles Carried on Transgenic Constructs Show
Allele of bft Class Mutagen Stocks Known lesion
Aneuploid Aberrations
Useful deficiency	Df(2L)esc10
Useful duplication	Dp(2;2)da+20
Disrupted in	Df(2L)esc-P3-0 (Hardiman et al., 2002) Df(2L)esc10 (Hardiman et al., 2002) Df(2L)prd1.7 (Hardiman et al., 2002)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data
Insertions
	Type of insertions Name Expression data miscellaneous insertions PBac{RB}bfte01057 NA P{SUPor-P}KG08390 NA insertion of enhancer trap P{lacW}E8-2-46 No P{lacW}l(2)SH0489SH0489 No insertion of mobile activating element P{EPgy2}bftEY04690 NA P{EP}MESK1EP980 NA P{GSV1}EP-M32EP-M32 NA P{Mae-UAS.6.11}B0079B0079 NA
Related Comments
	Please look at the allele reports for the complete phenotype data
Gene Ontology: Function, Process & Cellular Component ( 1 )
Molecular Function
CV term Evidence References
Biological Process
CV term Evidence References
bristle morphogenesis non-traceable author statement (Hardiman, 2000.2.14) inferred from mutant phenotype (Hardiman et al., 2002) non-traceable author statement (Hardiman, 2002.2.22)
Cellular Component
CV term Evidence References
Sequence Ontology: Class of Gene
	non_protein_coding_gene (Hardiman, 2000.2.14, Hardiman, 2000.10.17) nuclear_gene (Hardiman, 2000.2.14, Hardiman, 2000.10.17)
Interactions & Pathways
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions bft allele Gene References bft225 ct (Hardiman et al., 2002) bft6 ct (Hardiman et al., 2002) ttk (Hardiman et al., 2002)
External Data
Linkouts	BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions • 533768
Orthologs
Genome-wide drosophilid orthologs
Curated drosophilid orthologs
Linkouts
Functional Complementation between Species
Inter-Species Misexpression Data
Produces phenotype in
Produces NO phenotype in
Stocks & Reagents
Stocks Listed in FlyBase ( 5 )
Szeged	- P{EP}MESK1EP980 - P{lacW}l(2)SH0489SH0489
Harvard	- PBac{RB}bfte01057
Bloomington	14721 y1 w67c23; P{SUPor-P}KG08390 19844 y1 w67c23; P{EPgy2}bftEY04690
Genomic Clones ( 1 )
	BACR37P12
cDNA Clones ( 1 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	LP06727
Other clones
RNAi & Array Information
Affy Oligo
Linkouts	DRSC - RNAi screening (Harvard): high-throughput cell culture data and design • FBgn0041606
Other Information
Discoverer
Etymology
Identification
Position Effect Variegation Data
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments	"MESK1" may correspond to "bft". (Levis, 2003.1.9)
Comments About Role
Comments About Molecular Function
	bft transcripts do not obviously code for a protein product, thus bft either encodes a very small protein or may act as an RNA. Overall orientation not stated: bft+ BEST:LP06727+ bft+ (Hardiman et al., 2002)
Other Comments
	New annotation (CR31863) in release 3 of the genome annotation. (FlyBase Genome Annotators, 2002-2003)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NR_001644 NR_001643 DDBJ / EMBL / GenBank • AE003634 AF234639 AF234640 AF313801 AF486813 CL705794 CZ478879
Other Crossreferences
Linkouts
	BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions • 533768 DRSC - RNAi screening (Harvard): high-throughput cell culture data and design • FBgn0041606 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0041606 FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0041606 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /hjmuller/bereft1.htm
Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	bft (Molnar et al., 2006) CR31863 (Molnar et al., 2006, Grieder et al., 2006)
Name Synonym	bereft (Hardiman, 2000.10.17, Hardiman, 2000.2.14)
Secondary FlyBase IDs
	FBgn0051863
References ( 13 )
Research paper	Molnar et al., 2006, Genetics 174(3): 1635--1659 A gain-of-function screen identifying genes required for vein formation in the Drosophila melanogaster wing. [FBrf0195387] Hardiman et al., 2002, Genetics 161(1): 231--247 The bereft gene, a potential target of the neural selector gene cut, contributes to bristle morphogenesis. [FBrf0149016] Misra et al., 2002, GenomeBiol. 3(12): RESEARCH0083 Annotation of the Drosophila melanogaster euchromatic genome: a systematic review. [FBrf0155827]
Supplementary material	Grieder et al., 2006, Genetics 175(4): Supplemental Data. [FBrf0204785] Oh et al., 2003, Genetics 163(1): Table S1. [FBrf0157097]
Personal communication to FlyBase	Levis, 2003.1.9, Genes bft and MESK1 are probably allelic. Genes bft and MESK1 are probably allelic. [FBrf0155360]
FlyBase analysis	FlyBase Genome Annotators, 2002-2003, Changes affecting gene model number or type in releases 3.0 and 3.1 of the annotated D.melanogaster genome. Changes affecting gene model number or type in releases 3.0 and 3.1 of the annotated D.melanogaster genome. [FBrf0148886] FlyBase, 1992-, FlyBase curation FlyBase curation. [FBrf0105495]
DNA/RNA sequence record	Hardiman, 2002.2.22, GenBank/EMBL/DDBJ: AF486813 Drosophila melanogaster bereft long form (bft) mRNA, complete sequence, alternatively spliced. [FBrf0147264] Hardiman, 2000.10.17, GenBank/EMBL/DDBJ: AF313801 Drosophila melanogaster bereft (bft) mRNA, complete sequence. [FBrf0132824] Hardiman, 2000.2.14, GenBank/EMBL/DDBJ: AF234639 Drosophila melanogaster bereft gene, exon 1. [FBrf0127897]
Computer file	Gene Disruption Project members and Exelixis, 2005, Genomic mapping of Exelixis insertion collection. Genomic mapping of Exelixis insertion collection. [FBrf0184340] Gene Disruption Project members, 2001-, [title not yet available] [title not yet available] [FBrf0132177]