Gene Dmel\lilli

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General Information

Symbol

Dmel\lilli

Species

D. melanogaster

Name

lilliputian

Annotation symbol

CG8817

Feature type

protein_coding_gene

FlyBase ID

FBgn0041111

Created / Updated

2003-12-01/2003-12-01

Genomic Location

Chromosome (arm)

Recombination map

Cytogenetic map

23C1-23C3

Sequence location

2L:2,885,952..2,953,077 [+]

Map ( GBrowse )

Summary Information

Automatically generated summary

See sections below for more information

The gene lilliputian is referred to in FlyBase by the symbol lilli (CG8817, FBgn0041111). It has the cytological map location 23C1-23C3. Its sequence location is 2L:2885952..2953077. Its molecular function is described as: DNA binding; transcription factor activity. It is involved in the biological processes: periodic partitioning; compound eye photoreceptor development; regulation of cell size; cytokinesis, contractile ring formation; segment specification; olfactory behavior. 58 alleles are reported. The phenotypes of these alleles are annotated with 21 unique terms, many of which group under: organ system; peripheral nervous system; nervous system; embryonic tagma; egg; embryonic segment; embryonic head; cuticle; yolk; integumentary system. It has 7 annotated transcripts and 7 annotated polypeptides.

External Summaries

Detailed Mapping Data

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

23C1-23C3

Limits computationally determined from genome sequence between P{PZ}oho23B⁰³⁵⁷⁵ and P{PZ}lilli⁰⁰⁶³²

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

23C1-23C2

(Wittwer, 2000.8.7)

23C1-23C2

(Tang, 2000.3.5)

23C1-23C2

(determined by in situ hybridisation)

(Spradling et al., 1999)

23C1-23C2

(determined by in situ hybridisation)

(Perrimon et al., 1996)

23C1-23C2

(BDGP Project Members, 1994-1999)

Experimentally Determined Recombination Data

Location

(Neufeld et al., 1998)

Left of (cM)

Right of (cM)

Notes

Molecular Map Data

Gene Order (in direction of increasing cytology)

References

Gene Order (overall orientation not stated)

References

Overall orientation not stated: βggt-II+ NTPase- lilli+ Rbp9+

(Wittwer et al., 2001)

Gene Model & Products

Please see the GBrowse view of Dmel\lilli for information on other features

Comments on Gene Model

EST data support existence of multiple transcripts due to variable use of 5' exons.

EST data support existence of multiple transcripts due to variable use of mini-exons.

DGC clones appear problematic (LD18077 and LD28949): incomplete CDS; GM02019 may be okay.

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Associated CDS (aa)

lilli-RA

FBtr0077632

NM_164516

8019

1673

lilli-RB

FBtr0077633

NM_078740

8331

1673

lilli-RC

FBtr0077634

NM_164517

7243

1673

lilli-RD

FBtr0290038

5794

1614

lilli-RE

FBtr0290039

6134

1614

lilli-RF

FBtr0290040

5874

1614

lilli-RG

FBtr0290041

7438

1673

Additional Transcript Data & Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kD)

Length (aa)

Theoretical pI

RefSeq ID

GenBank protein

lilli-PA

FBpp0077317

180.1

1673

9.69

NP_722863

AAF51180

lilli-PB

FBpp0077318

180.1

1673

9.69

NP_523464

AAN10399

lilli-PC

FBpp0077319

180.1

1673

9.69

NP_722864

AAN10400

lilli-PD

FBpp0288477

173.0

1614

9.76

lilli-PE

FBpp0288478

173.0

1614

9.76

lilli-PF

FBpp0288479

173.0

1614

9.76

lilli-PG

FBpp0288480

180.1

1673

9.69

Additional Polypeptide Data & Comments

Reported size (kD)

Comments

External Data

Linkouts

PANTHER - Protein classification by function, families, and pathways

•

FBgn0041111

Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

HMG-I and HMG-Y, DNA-binding (IPR000637)

AF-4 proto-oncoprotein (IPR007797)

Sequences Consistent with the Gene Model

DDBJ /
EMBL /
GenBank

DNA sequence

Protein sequence

Name

Maps to

Does NOT map to

Identified with

(Oliver, 2001.8.16)

(Wittwer et al., 2001)

(BDGP Project Members, 2000-)

LD18077

(BDGP Project Members, 2000-, Wittwer et al., 2001, Oliver, 2001.8.16)

Mapped Features & Mutations

Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here

Type

Symbol & Location

Additional Notes

References

point mutation

lilli[22E1]
2L:2,948,320..2,948,320

evidence=experimental
na_change=C2948320T
pr_change=Q500|lilli-PB,Q500|lilli-PA,Q500@|lilli-PC
reported_na_change=C?T
reported_pr_change=Q500@|FBrf0134580

(Wittwer et al., 2001)

point mutation

lilli[4P5]
2L:2,949,229..2,949,229

reported_pr_change=R803@|FBrf0134580
evidence=experimental
na_change=C2949229T
pr_change=R803|lilli-PB,R803|lilli-PA,R803@|lilli-PC
reported_na_change=C?T

(Wittwer et al., 2001)

point mutation

lilli[5X5]
2L:2,950,120..2,950,120

evidence=experimental
na_change=C2950120T
pr_change=Q1100|lilli-PB,Q1100|lilli-PA,Q1100@|lilli-P C
reported_na_change=C?T
reported_pr_change=Q1100@|FBrf0134580

(Wittwer et al., 2001)

point mutation

lilli[3E8]
2L:2,950,396..2,950,396

evidence=experimental
na_change=C2950396T
pr_change=Q1192|lilli-PB,Q1192|lilli-PA,Q1192@|lilli-P C
reported_na_change=C?T
reported_pr_change=Q1192@|FBrf0134580

(Wittwer et al., 2001)

point mutation

lilli[16F1]-1
2L:2,951,277..2,951,277

comment=One of two nucleotide substitutions associated with this allele.
evidence=experimental
na_change=A2951277T
pr_change=Y1459F|lilli-PB,Y1459F|lilli-PA,Y1459F|lilli-P C
reported_na_change=A?T
reported_pr_change=Y1459F|FBrf0134580

(Wittwer et al., 2001)

point mutation

lilli[16F1]-2
2L:2,951,283..2,951,283

comment=One of two nucleotide substitutions associated with this allele.
evidence=experimental
na_change=A2951283T
pr_change=E1461V|lilli-PB,E1461V|lilli-PA,E1461V|lilli-P C
reported_na_change=A?T
reported_pr_change=E1461V|FBrf0134580

(Wittwer et al., 2001)

point mutation

lilli[17G1]
2L:2,952,097..2,952,097

evidence=experimental
na_change=C2952097T
pr_change=R1632|lilli-PB,R1632|lilli-PA,R1632@|lilli-P C
reported_na_change=C?T
reported_pr_change=R1632@|FBrf0134580

(Wittwer et al., 2001)

External Data

Linkouts

DEDB - Drosophila exon database: splicing graphs

•

5502

Crossreferences

Expression Data

FlyBase-Curated Data

Transcript and
Protein data

Please see the FlyBase Gene Expression Report for details of gene expression from the literature.

Summary of Transcript Expression

Stage

Tissue/Position

Reference

Marker for

Subcellular Localization

CV Term

Summary of Polypeptide Expression

Stage

Tissue/Position

Reference

Marker for

Subcellular Localization

CV Term

Microarray Data

Developmental timecourse, Costello et al., 2008 (Original data from Arbeitman et al., 2002)

Untitled Document detailed view

AA950408
AI113593
AI404098

External Data & Images

Linkouts

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0041111

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

•

FBgn0041111

GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies

•

FBgn0041111

Alleles & Phenotypes

Summary of Allele Phenotypes

Lethality

Allele

viable

lethal (with Df(2L)C144)

lilli^a16

lethal | recessive

lethal | embryonic stage | maternal effect | poor

lilli⁰⁰⁶³²

lethal | embryonic stage | recessive

lilli^unspecified

lethal | embryonic stage | germ-line clone | maternal effect | recessive

lethal | embryonic stage | germ-line clone | non-rescuable maternal effect | recessive

lethal | larval stage | recessive

lilli⁰⁰⁶³²

Other Phenotypes

Allele

visible | recessive

lilli^unspecified

visible | recessive | somatic clone

small body | recessive | somatic clone

lilli^4U5

reduced cell size | recessive | somatic clone

olfaction defective

lilli^BG02206

Sterility

Allele

fertile

Phenotype manifest in

Allele

embryonic/first instar larval cuticle | maternal effect

lilli⁰⁰⁶³²

segment | maternal effect

lilli⁰⁰⁶³²

eye photoreceptor cell | somatic clone

denticle belt | germ-line clone | maternal effect | terminal

embryonic head | germ-line clone | maternal effect

embryonic segment | germ-line clone | maternal effect

cephalopharyngeal skeleton | anterior | germ-line clone

lilli^3E8

filzkorper | germ-line clone

lilli^3E8

embryonic epidermis | germ-line clone

lilli^3E8

eye disc | somatic clone

lilli^4U5

eye | somatic clone

lilli^4U5

adult head | somatic clone

lilli^4U5

ommatidium | somatic clone

lilli^4U5

embryo | germ-line clone | pair rule

embryonic abdominal segment | germ-line clone

lilli^XS575

denticle belt | germ-line clone

lilli^XS575

embryonic/first instar larval cuticle | germ-line clone

lilli^XS575

cephalic furrow | germ-line clone

lilli^XS575

extended germ band embryo | germ-line clone

lilli^XS575

actin filament & embryo | germ-line clone

lilli^XS575

yolk | germ-line clone

lilli^XS575

lipid droplet | germ-line clone

lilli^XS575

wing margin bristle | somatic clone

lilli^XS575

embryonic head (with Df(2L)C144)

lilli^a16

filzkorper (with Df(2L)C144)

lilli^a16

denticle belt (with Df(2L)C144)

lilli^a16

rhabdomere | somatic clone

Classical Alleles ( 53 )

For All Classical Alleles Show

Allele of lilli	Mutagen	Stocks	Known lesion
lilli⁰⁰⁶³²	P-element activity	1	Yes
lilli^11L1	ethyl methanesulfonate	0	--
lilli^14C6	ethyl methanesulfonate	0	--
lilli^15D1	ethyl methanesulfonate	0	--
lilli^16F1	ethyl methanesulfonate	0	--
lilli^16Q1	ethyl methanesulfonate	0	Yes
lilli^17G1	ethyl methanesulfonate	0	--
lilli^17K2	ethyl methanesulfonate	0	--
lilli^189Y		0	Yes
lilli^22E1	ethyl methanesulfonate	0	--
lilli^2L-193-35	ethyl methanesulfonate	0	--
lilli^2L-75-1	ethyl methanesulfonate	0	--
lilli^3E8	ethyl methanesulfonate	0	--