A Database of Drosophila Genes & Genomes

FB2008_07, released August 8, 2008
 

Gene Dmel\HGTX

General Information
SymbolDmel\HGTXSpeciesD. melanogaster
NameHGTXAnnotation symbolCG13475
Feature typeprotein_coding_geneFlyBase IDFBgn0040318
Created / Updated2003-12-01/2007-10-03
Genomic Location
Chromosome (arm)3LRecombination map
Cytogenetic map70E3-70E3Sequence location3L:14,576,315..14,593,071 [-]
Map ( GBrowse ) detailed view
hide Summary Information
Automatically generated summary

See sections below for more information
This gene is referred to in FlyBase by the symbol HGTX (CG13475, FBgn0040318). It has the cytological map location 70E3. Its sequence location is 3L:14576315..14593071. Its molecular function is described as: transcription factor activity; sequence-specific DNA binding. It is involved in the biological processes: nervous system development; regulation of transcription; regulation of transcription, DNA-dependent. 8 alleles are reported. The phenotypes of these alleles are annotated with: RP2 neuron; U neuron; EL neuron; EW neuron; motor neuron. It has 2 annotated transcripts and 2 annotated polypeptides.

External Summaries

hide Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
70E3-70E3  
Limits computationally determined from genome sequence between P{PZ}Mpcp00564 and P{PZ}l(3)rO220rO220  
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
70E4-70E5
 
(Garbern, 1999.12.30)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Molecular Map Data
Gene Order (in direction of increasing cytology)
References
Gene Order (overall orientation not stated)
References
hide Gene Model & Products
Please see the GBrowse view of Dmel\HGTX for information on other features
detailed view FBtr0075720 FBtr0114619 FBpp0075463 FBpp0113111 FBti0066912 FBti0042728
Comments on Gene Model
hide Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Associated CDS (aa)
HGTX-RA
FBtr0075720
 NM_144357
  3049
  513
HGTX-RB
FBtr0114619
 
  2470
  605
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
hide Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kD)
Length (aa)
Theoretical pI
RefSeq ID
GenBank protein
HGTX-PA  
FBpp0075463  
54.6  
513  
8.60  
  NP_652614
  AAF49729
HGTX-PB  
FBpp0113111  
64.3  
605  
8.84  
 
 
Additional Polypeptide Data & Comments
Reported size (kD)
Comments
External Data
Linkouts
PANTHER - Protein classification by function, families, and pathways
•
Crossreferences
InterPro domains - A database of protein families, domains, and functional sites
•
Helix-turn-helix motif, lambda-like repressor (IPR000047)
Homeobox (IPR001356)
Homeodomain-like (IPR009057)
Homeodomain-related (IPR012287)
hide Sequences Consistent with the Gene Model
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
AE003534
AAF49729
 
AF220236
AAF33780
 
AY089592
AAL90330
 
BI172643
 
BI213161
 
BI232767
 
BI483735
 
BI579799
 
BT015992
AAV36877
 
CO295953
 
CO328710
 
CO341408
 
CZ480958
 
EC084011
 
EC201683
 
EC211364
 
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
    Maps to
    Does NOT map to
    Identified with
    (BDGP Project Members, 2000-)
    (Cheesman et al., 2004)
    (Hoskins et al., 2005)
    hide Mapped Features & Mutations
    Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here
    Type
    Symbol & Location
    Additional Notes
    References
    hide External Data
    Linkouts
    DEDB - Drosophila exon database: splicing graphs
    •
    Crossreferences
    hide Expression Data
    FlyBase-Curated Data
    Transcript and
    Protein data     		Please see the FlyBase Gene Expression Report for details of gene expression from the literature.
    hide Summary of Transcript Expression
    Stage
    Tissue/Position
    Reference
    Marker for
      Subcellular Localization
      CV Term
      hide Summary of Polypeptide Expression
      Stage
      Tissue/Position
      Reference
      Marker for
        Subcellular Localization
        CV Term
        hide External Data & Images
        Linkouts
        FLIGHT - Cell culture data for RNAi and other high-throughput technologies
        •
        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
        •
        GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies
        •
        BDGP expression data
        •
        Show all BDGP original images, annotations and embryonic microarray data for HGTX
        FlyExpress - Embryonic expression images (BDGP data)
        •
        Show all FlyExpress processed images for HGTX
        hide Alleles & Phenotypes
        hide Summary of Allele Phenotypes
        Other Phenotypes
        Allele
        neuroanatomy defective | embryonic stage
        neuroanatomy defective, with Scer\GAL4sca.PU
        Phenotype manifest in
        Allele
        anterior fascicle & stage 16 embryo
        interneuron & axon & longitudinal connective
        RP neuron & axon & embryo
        anterior fascicle & stage 16 embryo (with HGTXP-JG)
        anterior fascicle & stage 16 embryo (with Df(3L)fz-D21)
        anterior fascicle & stage 16 embryo (with HGTXD25)
        anterior fascicle & embryo, with Scer\GAL4elav.PLu
        RP2 neuron | ectopic, with Scer\GAL4sca.PU
        U neuron, with Scer\GAL4sca.PU
        EL neuron, with Scer\GAL4sca.PU
        EW neuron, with Scer\GAL4sca.PU
        motor neuron, with Scer\GAL4sca.PU
        hide Classical Alleles ( 5 )
        For All Classical Alleles Show

        Allele of HGTXClassMutagenStocksKnown lesion
        HGTXD250 Yes
        HGTXGAL40 --
        HGTXP-JGhypomorph
          		0 Yes
          HGTXd00083
            		2 --
            HGTXe031901 --
            hide Alleles Carried on Transgenic Constructs ( 3 )
            For All Alleles Carried on Transgenic Constructs Show

            Allele of HGTXClassMutagenStocksKnown lesion
            HGTXGD40981 Yes
            HGTXScer\UAS.cBa1 Yes
            HGTXScer\UAS.cCa0 Yes
            hide Aneuploid Aberrations
            Useful deficiency
               
            Useful duplication
             
            Disrupted in
            (Ryder, 2004.4.26)
            (Broihier et al., 2004)
            Partially disrupted in
            (Broihier et al., 2004)
            hide Transgenic Constructs & Insertions
            Transgenic Constructs
            Type of construct
            Name
            Expression data
            UAS construct
            P{GD4098}
            NA
            P{UAS-HGTX.B}
            NA
            P{UAS-Nkx6.C}
            NA
            Insertions
            Type of insertions
            Name
            Expression data
            miscellaneous insertions
            PBac{RB}HGTXe03190
            NA
            insertion of enhancer trap binary system
            P{GAL4}HGTXGAL4
            No
            insertion of enhancer trap
            P{lacZ}HGTXP-JG
            No
            insertion of mobile activating element
            P{XP}HGTXd00083
            NA
            hide Related Comments
            Please look at the allele reports for the complete phenotype data
            Misexpression of HGTX severely disrupts neuronal fates.
            (Broihier et al., 2002)
            hide Gene Ontology: Function, Process & Cellular Component ( 6 )
            hide Molecular Function
            CV term
            Evidence
            References
            sequence-specific DNA binding
            inferred from electronic annotation with InterPro:IPR001356
            (FlyBase Curators et al., 2004-)
            transcription factor activity
            inferred from sequence or structural similarity with EMBL:AY437556
            (FlyBase, 1992-)
            hide Biological Process
            CV term
            Evidence
            References
            nervous system development
            inferred from mutant phenotype
            (Broihier et al., 2002)
            regulation of transcription
            inferred from sequence or structural similarity with EMBL:AY437556
            (FlyBase, 1992-)
            regulation of transcription, DNA-dependent
            inferred from electronic annotation with InterPro:IPR000047, InterPro:IPR001356
            (FlyBase Curators et al., 2004-)
            hide Cellular Component
            CV term
            Evidence
            References
            nucleus
            inferred from sequence or structural similarity with EMBL:AY437556
            (FlyBase, 1992-)
            hide Sequence Ontology: Class of Gene
            protein_coding_gene
             
            nuclear_gene
             
            hide Interactions & Pathways
            hide Summary of Genetic Interactions
            Interacts with
            Please look at the allele data for full details of the genetic interactions
            HGTX allele
            Gene
            References
            HGTXD25
            exex
            (Broihier et al., 2004)
            hide External Data
            Linkouts
            BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions
            •
            hide Orthologs
            Genome-wide drosophilid orthologs
            Curated drosophilid orthologs
             
            Linkouts
            InParanoid orthologs - Eukaryotic orthologs
            •
            hide Functional Complementation between Species
            hide Inter-Species Misexpression Data
            Produces phenotype in
            Produces NO phenotype in
            hide Stocks & Reagents
            hide Stocks Listed in FlyBase ( 5 )
            Harvard
            -
            P{XP}HGTXd00083
            -
            PBac{RB}HGTXe03190
            Bloomington
            9932
            w*; P{UAS-HGTX.B}26
            19133
            w1118; P{XP}HGTXd00083/TM6B, Tb1
            VDRC
            v12608
            w1118; P{GD4098}v12608
            hide Genomic Clones ( 2 )
            hide cDNA Clones ( 9 )
            Please Note
            This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
            cDNA Clones, Fully Sequenced
            BDGP DGC clones
            Other clones
            cDNA Clones, End Sequenced (ESTs)
            BDGP DGC clones
            Other clones
            hide RNAi & Array Information
            Affy Oligo
            Linkouts
            DRSC - RNAi screening (Harvard): high-throughput cell culture data and design
            •
            GenomeRNAi - RNAi phenotypes (Heidelberg): high-throughput cell culture data
            •
            hide Antibody Information
            hide Other Information
            hide Discoverer
            hide Etymology
            hide Identification
            hide Position Effect Variegation Data
            hide Relationship to Other Genes
            Source for database identity of
            Source for database merge of
            Source for merge of: HGTX CG13475 CG4745
            (Bayraktaroglu, 2000.8.7)
            Source for merge of: HGTX Nkx6
            (Broihier et al., 2004)
            Additional comments
            hide Comments About Role
            hide Comments About Molecular Function
            hide Other Comments
            Identification: Comparative genomic approach to identify and screen potential regulators of eve and exex.
            (Broihier et al., 2002)
            hide External Crossreferences & Linkouts
            Sequence Crossreferences
            RefSeq (Transcripts)
            •
            RefSeq (Proteins)
            •
            DDBJ / EMBL / GenBank
            •
            UniProtKB/TrEMBL
            •
            Other Crossreferences
            InterPro domains - A database of protein families, domains, and functional sites
            •
            Helix-turn-helix motif, lambda-like repressor (IPR000047)
            Homeobox (IPR001356)
            Homeodomain-like (IPR009057)
            Homeodomain-related (IPR012287)
            Linkouts
            BDGP expression data
            •
            Show all BDGP original images, annotations and embryonic microarray data for HGTX
            BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions
            •
            DEDB - Drosophila exon database: splicing graphs
            •
            DRSC - RNAi screening (Harvard): high-throughput cell culture data and design
            •
            FLIGHT - Cell culture data for RNAi and other high-throughput technologies
            •
            FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
            •
            FlyExpress - Embryonic expression images (BDGP data)
            •
            FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans
            •
            GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies
            •
            GenomeRNAi - RNAi phenotypes (Heidelberg): high-throughput cell culture data
            •
            InParanoid orthologs - Eukaryotic orthologs
            •
            Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
            •
            PANTHER - Protein classification by function, families, and pathways
            •
            hide Synonyms & Secondary IDs ( 6 )
            Reported As
            Symbol Synonym
            CG4745
            (Popovici et al., 2001, Coulier et al., 2000, )
            CG13475
            (Cheesman et al., 2004)
            dNkx6
            (Broihier et al., 2002)
            HGTX
            (Skeath, 2007.3.20, Hoskins et al., 2005)
            Nk6
            (Uhler et al., 2002, Seibert et al., 2008, Uhler et al., 2002)
            Nkx6
            (Broihier et al., 2004, Layden et al., 2006, Cheesman et al., 2004)
            Name Synonym
            HGTX
             
            Secondary FlyBase IDs
            • FBgn0036430
            • FBgn0036431
            • FBgn0062262
            hide References ( 26 )
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            hide Recent research papers ( 1 )
            Layden et al., 2006, Dev. Biol. 291(2): 253--263
            Zfh1, a somatic motor neuron transcription factor, regulates axon exit from the CNS. [FBrf0190136]
            Show all research papers ...