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Gene Dmel\raps

General Information
Symbol	Dmel\raps	Species	D. melanogaster
Name	rapsynoid	Annotation symbol	CG5692
Feature type	protein_coding_gene	FlyBase ID	FBgn0040080
Created / Updated	2003-12-01/2003-12-01
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	98A8-98A8	Sequence location	3R:23,408,527..23,412,099 [+]
Map ( GBrowse )	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene rapsynoid is referred to in FlyBase by the symbol raps (CG5692, FBgn0040080). It has the cytological map location 98A8. Its sequence location is 3R:23408527..23412099. Its molecular function is described as: GTPase activator activity; binding. It is involved in the biological processes described with 12 unique terms, many of which group under: macromolecule localization; anatomical structure development; protein localization; cell fate commitment; cell cycle; cell division; organelle organization and biogenesis; establishment of mitotic spindle localization; cell proliferation; cell cycle process. 17 alleles are reported. The phenotypes of these alleles are annotated with: RP2 neuron; RP2sib neuron; ganglion mother cell GMC4-2a; neuroblast; spindle; wing margin; anterior fascicle. It has one annotated transcript and one annotated polypeptide.
External Summaries
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 98A8-98A8   Limits computationally determined from genome sequence between P{PZ}sda03884 and P{PZ}btzrL203
Experimentally Determined Cytological Location
Cytogenetic map Notes References 98A-98B   (Schaefer, 2000.3.6) 98A-98B   (Parmentier, 2000.2.15) 98A-98B   (Yu, 2000.1.31)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Molecular Map Data
Gene Order (in direction of increasing cytology) References Gene Order (overall orientation not stated) References
Gene Model & Products
Please see the GBrowse view of Dmel\raps for information on other features
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) raps-RA FBtr0085189  NM_080260   3315   658
Additional Transcript Data & Comments
Reported size (kB)	3.3 (northern blot) (Yu et al., 2000)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kD) Length (aa) Theoretical pI RefSeq ID GenBank protein raps-PA   FBpp0084559   71.5   658   6.73     NP_524999   AAF56721
Additional Polypeptide Data & Comments
Reported size (kD)	658 (aa); 72 (kD predicted) (Yu et al., 2000)
Comments
External Data
Linkouts	PANTHER - Protein classification by function, families, and pathways • FBgn0040080
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Tetratricopeptide TPR-1 (IPR001440) GoLoco (IPR003109) Tetratricopeptide-like helical (IPR011990) Tetratricopeptide region (IPR013026) Tetratricopeptide TPR2 (IPR013105)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA141339   AA201866   AA201963   AA246454   AA246483   AA246961   AA263406   AA264779   AA264941   AA391174   AA438798   AA439647   AA441535   AA538796   AA539912   AA540075   AA540752   AA695130   AA736057   AA950460   AA979142   AA979309   AE003761 AAF56721   AF230071 AAF36967   AF242203 AAF64499   AI405187   AI518275   AI519893   AI520272   AJ272067 CAB75734   AQ254704   AW943195   AY094817 AAM11170   BI168474   BI168532   BI231660   BI234458   BI234624   BI234736   BI239201   BI240700   BI362717   BI362726   BI366232   BI367135   BI367178   BI368454   BI370260   BI484306   BI580665   BI635921   BI638936   BT003523 AAO39527   CO273333   CO273424   CO290444   CO294845   CO296452   CO299892   CO310139   CO321596   CO325524   CO325765   CO325987   CZ470949   EC063466   EC072105   EC077399   EC083394   EC087494   EC199118   EC199777   EC204274   EC212604   EC220820   EC222211   EC223959   EC230823   EC232877   EC247465
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9NFR7 Q9NH88 Q9VB22
Maps to
Does NOT map to
Identified with	GM02189 (Parmentier et al., 2000) LD33695 RE22964 (BDGP Project Members, 2000-)
Mapped Features & Mutations
Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here Type Symbol & Location Additional Notes References
External Data
Linkouts	DEDB - Drosophila exon database: splicing graphs • 11042
Crossreferences
Expression Data
FlyBase-Curated Data
Transcript and Protein data	Please see the FlyBase Gene Expression Report for details of gene expression from the literature.
Summary of Transcript Expression
Stage Tissue/Position Reference
Marker for
Subcellular Localization
CV Term
Summary of Polypeptide Expression
Stage Tissue/Position Reference  embryonic stage  neuroblast (Yu et al., 2000)  embryonic stage  mitotic domain 9 (Yu et al., 2000)
Marker for
Subcellular Localization
CV Term
Microarray Data
	Developmental timecourse, Costello et al., 2008 (Original data from Arbeitman et al., 2002) AA979309
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0040080 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • FBgn0040080 GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies • FBgn0040080 BDGP expression data • Show all BDGP original images, annotations and embryonic microarray data for raps FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for raps Stage(s) 1-3 Stage(s) 4-6 Stage(s) 9-10 Stage(s) 11-12 Stage(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable rapsΔ24 rapsΔ50 lethal | pupal stage | recessive raps179 raps193 raps83 Other Phenotypes Allele cell polarity defective rapsP62 rapsP89 mitotic cell cycle defective raps193 rapsΔ50 mitotic cell cycle defective (with rapsΔ50) raps193 mitotic cell cycle defective (with raps193) rapsΔ50 mitotic cell cycle defective | embryonic stage rapsP89 neuroanatomy defective rapsP62 neuroanatomy defective | embryonic stage rapsP89 neuroanatomy defective | larval stage, with Scer\GAL4elav-C155 rapsEP3113 neuroanatomy defective, with Scer\GAL4elav-C155 rapsEP3113 tumorigenic (with rapsP89) rapsP62 tumorigenic (with rapsP62) rapsP89 Phenotype manifest in Allele spindle rapsΔ24 rapsΔ50 rapsP62 wing margin (with raps193) rapsΔ50 wing margin rapsΔ50 wing margin (with rapsΔ50) raps193 neuroblast & larva raps193 anterior fascicle, with Scer\GAL4elav-C155 rapsEP3113 anterior fascicle & synapse, with Scer\GAL4elav-C155 rapsEP3113 anterior fascicle & synapse | supernumerary, with Scer\GAL4elav-C155 rapsEP3113 larval brain & neuroblast rapsP62 mitotic cell cycle & spindle rapsP62 rapsP89 mitotic domain 9 & spindle rapsP62 rapsP89 embryonic neuroblast & spindle rapsP62 rapsP89 RP2 neuron rapsP62 rapsP89 RP2 neuron | ectopic rapsP62 rapsP89 RP2sib neuron rapsP62 rapsP89 mitotic domain 9 & epithelial cell rapsP62 ganglion mother cell GMC4-2a rapsP89 neuroblast rapsP89 neuroblast & pupa rapsunspecified
Classical Alleles ( 12 )
For All Classical Alleles Show
Allele of raps Class Mutagen Stocks Known lesion raps179 hypomorph Δ2-3 0 Yes raps193 hypomorph Δ2-3 1 Yes raps83 hypomorph Δ2-3 1 Yes rapsEP3113 P-element activity 1 Yes rapsP120 Δ2-3 0 Yes rapsP17 Δ2-3 0 Yes rapsP62 amorph, loss of function Δ2-3 0 Yes rapsP89 loss of function Δ2-3 0 Yes rapsc06721 piggyBac transposase 1 -- rapsunspecified 0 -- rapsΔ24 P-element activity 0 Yes rapsΔ50 P-element activity 0 Yes
Alleles Carried on Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Allele of raps Class Mutagen Stocks Known lesion rapsC.Hsp70Bb.T:Zzzz\FLAG,T:Zzzz\FLAG in vitro construct | regulatory fusion in vitro construct | deletion in vitro construct | coding region fusion 0 Yes rapsC.Scer\UAS.T:Zzzz\FLAG,T:Zzzz\FLAG in vitro construct | regulatory fusion in vitro construct | deletion 0 Yes rapsGD11737 in vitro construct | RNAi in vitro construct | regulatory fusion 1 Yes rapsScer\UAS.cYa in vitro construct | regulatory fusion 0 Yes rapshs.PP in vitro construct | regulatory fusion 1 Yes
Aneuploid Aberrations
Useful duplication	Dp(3;3)M95A+13
Disrupted in	Df(3R)BSC497 (Christensen et al., 2008.4.15) Df(3R)BSC498 (Christensen et al., 2008.4.15) Df(3R)IR16 (Parmentier et al., 2000)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD11737} NA P{UAS-pins.Y} NA P{UAS-raps.C} NA characterization construct P{UAS-pon::raps.C-pon} NA heat-shock construct P{hs-raps.C} NA P{hs-raps.P} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions PBac{PB}rapsc06721 NA P{SUPor-P}wdbKG02977 NA P{UASp-YFP.Rab30.T21N}wdb07 NA insertion of mobile activating element P{EPgy2}EY00550a NA P{EP}rapsEP3113 NA P{EP}wdbEP3106 NA P{EP}wdbEP3211 NA P{EP}wdbEP3316 NA P{EP}wdbEP3385 NA P{EP}wdbEP3559 NA P{GSV1}C442C442 NA
Related Comments
	Please look at the allele reports for the complete phenotype data In raps mutants, the asymmetric divisions of neuroblasts are altered; insc protein is no longer asymmetrically localized in the dividing neuroblast and the neuroblast division produces two daughter cells of similar sizes. However, the morphologically symmetrical divisions of raps mutant neuroblasts still lead to daughter cells with different fates, as shown by differences in gene expression. (Parmentier et al., 2000)
Gene Ontology: Function, Process & Cellular Component ( 17 )
Molecular Function
CV term Evidence References
GTPase activator activity inferred from electronic annotation with InterPro:IPR003109 (FlyBase Curators et al., 2004-)
binding inferred from electronic annotation with InterPro:IPR011990 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
asymmetric cell division non-traceable author statement (Parmentier, 2000.2.15) traceable author statement (Cheah et al., 2000) inferred from mutant phenotype (Parmentier et al., 2000) inferred from mutant phenotype (Yu et al., 2003)
asymmetric neuroblast division inferred from mutant phenotype (Cai et al., 2003)
asymmetric protein localization traceable author statement (Cheah et al., 2000)
asymmetric protein localization during cell fate commitment traceable author statement (Gonczy, 2002)
basal protein localization traceable author statement (Peng et al., 2000)
establishment of mitotic spindle localization traceable author statement (Cheah et al., 2000) traceable author statement (Gonczy, 2002)
establishment of mitotic spindle orientation inferred from mutant phenotype (Yu et al., 2003)
establishment of spindle orientation inferred from mutant phenotype (Siegrist and Doe, 2005)
maintenance of protein location non-traceable author statement (Schaefer and Knoblich, 2001)
neuroblast fate determination traceable author statement (Cheah et al., 2000)
neuroblast proliferation inferred from mutant phenotype (Caussinus and Gonzalez, 2005)
signal transduction inferred from electronic annotation with InterPro:IPR003109 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
apical cortex traceable author statement (Ohshiro et al., 2000) traceable author statement (Schaefer and Knoblich, 2001) inferred from direct assay (Siegrist and Doe, 2005)
apical part of cell non-traceable author statement (Peng et al., 2000)
cell cortex traceable author statement (Bardin et al., 2004)
Sequence Ontology: Class of Gene
	protein_coding_gene   nuclear_gene
Interactions & Pathways
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions raps allele Gene References rapsP62 insc (Cai et al., 2003) rapsP89 baz (Fuse et al., 2003) rapsunspecified insc (Yu et al., 2003)
External Data
Linkouts