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Gene Dmel\CG17691

General Information
Symbol	Dmel\CG17691	Species	D. melanogaster
Name	CG17691	Annotation symbol	CG17691
Feature type	protein_coding_gene	FlyBase ID	FBgn0039993
Created / Updated	2007-03-02/2007-03-02
Genomic Location
Chromosome (arm)	U	Recombination map
Cytogenetic map		Sequence location	U:1,178,801..1,184,794 [+]
Map ( GBrowse )	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol CG17691 (FBgn0039993). Its sequence location is U:1178801..1184794. Its molecular function is described by 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity. It is involved in the biological process acyl-CoA biosynthetic process. No alleles are reported. It has 4 annotated transcripts and 4 annotated polypeptides.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location
Experimentally Determined Cytological Location
Cytogenetic map Notes References h44-h44 (determined by in situ hybridisation)   (Rossi et al., 2007)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Molecular Map Data
Gene Order (in direction of increasing cytology) References Gene Order (overall orientation not stated) References
Gene Model & Products
Please see the GBrowse view of Dmel\CG17691 for information on other features
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG17691-RA FBtr0113759  NM_001015354   1248   394 CG17691-RB FBtr0113758  NM_001110546   486   136 CG17691-RC FBtr0113761  NM_001110548   1264   364 CG17691-RD FBtr0113760  NM_001110547   969   40
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kD) Length (aa) Theoretical pI RefSeq ID GenBank protein CG17691-PA   FBpp0112482   44.0   394   7.97     NP_001015354   EAA46092 CG17691-PB   FBpp0112481   15.7   136   9.40     NP_001104016   EDP27995 CG17691-PC   FBpp0112484   40.3   364   7.45     NP_001104018   EDP27997 CG17691-PD   FBpp0112483   4.7   40   11.25     NP_001104017   EDP27996
Additional Polypeptide Data & Comments
Reported size (kD)
Comments
External Data
Linkouts	PANTHER - Protein classification by function, families, and pathways • FBgn0039993
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Transketolase, central region (IPR005475) Transketolase, C-terminal (IPR005476) Transketolase, C-terminal/Pyruvate-ferredoxin oxidoreductase, domain II (IPR009014) Transketolase C-terminal-like (IPR015941) MitoDrome - A database of annotated Dmel nuclear genes encoding mitochondrial proteins • MTDROME17691
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AABU01002750 EAA46092   AY071212 AAL48834   BI228252   BI228253
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q7PLE6 Q8SZ03
Maps to
Does NOT map to
Identified with	RE25729 RE25730 (BDGP Project Members, 2000-) RE25729 (Rossi et al., 2007)
Mapped Features & Mutations
Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
FlyBase-Curated Data
Transcript and Protein data	Please see the FlyBase Gene Expression Report for details of gene expression from the literature.
Summary of Transcript Expression
Stage Tissue/Position Reference
Marker for
Subcellular Localization
CV Term
Summary of Polypeptide Expression
Stage Tissue/Position Reference
Marker for
Subcellular Localization
CV Term
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0039993 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • FBgn0039993 GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies • FBgn0039993
Alleles & Phenotypes
Summary of Allele Phenotypes
Phenotype manifest in Allele
Classical Alleles ( 0 )
For All Classical Alleles Show
Allele of CG17691 Class Mutagen Stocks Known lesion
Alleles Carried on Transgenic Constructs ( 0 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG17691 Class Mutagen Stocks Known lesion
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data
Insertions
	Type of insertions Name Expression data
Related Comments
	Please look at the allele reports for the complete phenotype data
Gene Ontology: Function, Process & Cellular Component ( 3 )
Molecular Function
CV term Evidence References
3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity inferred from sequence or structural similarity with UniProtKB:P35738 (FlyBase, 1992-) inferred from sequence or structural similarity with UniProtKB:P21953 (Sardiello et al., 2003.6.11)
Biological Process
CV term Evidence References
acyl-CoA biosynthetic process inferred from sequence or structural similarity with UniProtKB:P12694 (Sardiello et al., 2003.6.11)
Cellular Component
CV term Evidence References
3-methyl-2-oxobutanoate dehydrogenase (lipoamide) complex inferred from sequence or structural similarity with UniProtKB:P35738 (FlyBase, 1992-) inferred from sequence or structural similarity with UniProtKB:P21953 (Sardiello et al., 2003.6.11)
Sequence Ontology: Class of Gene
	protein_coding_gene   nuclear_gene
Interactions & Pathways
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG17691 allele Gene References
External Data
Linkouts	BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions • 78194
Orthologs
Genome-wide drosophilid orthologs
Curated drosophilid orthologs
Linkouts	InParanoid orthologs - Eukaryotic orthologs • ENSANGP00000019119 Anopheles gambiae (Ensembl) ENSBTAP00000016044 Bos taurus (Ensembl) ENSCAFP00000004212 Canis familiaris (Ensembl) ENSCINP00000008821 Ciona intestinalis (Ensembl) NEWSINFRUP00000158426 Takifugu rubripes (Ensembl) ENSGALP00000025531 Gallus gallus (Ensembl) ENSP00000318351 Homo sapiens (Ensembl) ENSMMUP00000006415 Macaca mulatta (Ensembl) ENSPTRP00000031400 Pan troglodytes (Ensembl) ENSRNOP00000013249 Rattus norvegicus (Ensembl) GSTENP00013228001 Tetraodon nigroviridis (Ensembl) ENSXETP00000025757 Xenopus tropicalis (Ensembl) Q69LD2 Oryza sativa (Gramene) AT1G55510.1 Arabidopsis thaliana (Arabidopsis) WBGene00023706 Caenorhabditis briggsae (Wormbase) WBGene00006518 Caenorhabditis elegans (Wormbase) DDB0230185 Dictyostelium discoideum (Dictybase) MGI:88137 Mus musculus (Informatics)
Functional Complementation between Species
Inter-Species Misexpression Data
Produces phenotype in
Produces NO phenotype in
Stocks & Reagents
Stocks Listed in FlyBase ( 0 )
Genomic Clones ( 0 )
cDNA Clones ( 1 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones
Other clones	RE25729
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones
RNAi & Array Information
Affy Oligo
Linkouts
Antibody Information
Other Information
Discoverer
Etymology
Identification
Position Effect Variegation Data
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Comments About Role
Comments About Molecular Function
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_001110546 NM_001015354 NM_001110547 NM_001110548 RefSeq (Proteins) • NP_001104016 NP_001015354 NP_001104017 NP_001104018 DDBJ / EMBL / GenBank • AABU01002750 EAA46092 AY071212 AAL48834 BI228252 BI228253 UniProtKB/TrEMBL • Q7PLE6 Q8SZ03
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Transketolase, central region (IPR005475) Transketolase, C-terminal (IPR005476) Transketolase, C-terminal/Pyruvate-ferredoxin oxidoreductase, domain II (IPR009014) Transketolase C-terminal-like (IPR015941) MitoDrome - A database of annotated Dmel nuclear genes encoding mitochondrial proteins • MTDROME17691
Linkouts
	BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions • 78194 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0039993 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • FBgn0039993 FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0039993 GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies • FBgn0039993 InParanoid orthologs - Eukaryotic orthologs • ENSANGP00000019119 Anopheles gambiae (Ensembl) ENSBTAP00000016044 Bos taurus (Ensembl) ENSCAFP00000004212 Canis familiaris (Ensembl) ENSCINP00000008821 Ciona intestinalis (Ensembl) NEWSINFRUP00000158426 Takifugu rubripes (Ensembl) ENSGALP00000025531 Gallus gallus (Ensembl) ENSP00000318351 Homo sapiens (Ensembl) ENSMMUP00000006415 Macaca mulatta (Ensembl) ENSPTRP00000031400 Pan troglodytes (Ensembl) ENSRNOP00000013249 Rattus norvegicus (Ensembl) GSTENP00013228001 Tetraodon nigroviridis (Ensembl) ENSXETP00000025757 Xenopus tropicalis (Ensembl) Q69LD2 Oryza sativa (Gramene) AT1G55510.1 Arabidopsis thaliana (Arabidopsis) WBGene00023706 Caenorhabditis briggsae (Wormbase) WBGene00006518 Caenorhabditis elegans (Wormbase) DDB0230185 Dictyostelium discoideum (Dictybase) MGI:88137 Mus musculus (Informatics) PANTHER - Protein classification by function, families, and pathways • FBgn0039993
Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	CG17691 (Rossi et al., 2007, Drosophila Heterochromatin Genome Project, 2007)
Name Synonym	CG17691
Secondary FlyBase IDs
	FBan0017691
References ( 7 )
Research paper	Rossi et al., 2007, Genetics 175(2): 595--607 Cytogenetic and molecular characterization of heterochromatin gene models in Drosophila melanogaster. [FBrf0192814] Inlow and Restifo, 2004, Genetics 166(2): 835--881 Molecular and comparative genetics of mental retardation. [FBrf0174714]
Personal communication to FlyBase	Drosophila Heterochromatin Genome Project, 2007, Release 5.2 of the annotated Drosophila melanogaster heterochromatin. Release 5.2 of the annotated Drosophila melanogaster heterochromatin. [FBrf0199188] Drosophila Heterochromatin Genome Project, 2004, Release 3.2 of the annotated Drosophila melanogaster heterochromatin. Release 3.2 of the annotated Drosophila melanogaster heterochromatin. [FBrf0173307] Sardiello et al., 2003.6.11, MitoDrome: A database of Drosophila melanogaster nuclear genes encoding proteins targeted to the mitochondrion. MitoDrome: A database of Drosophila melanogaster nuclear genes encoding proteins targeted to the mitochondrion. [FBrf0159903]
FlyBase analysis	FlyBase, 1992-, FlyBase curation FlyBase curation. [FBrf0105495]
Computer file	BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0125078]