A Database of Drosophila Genes & Genomes

FB2008_07, released August 8, 2008
 

Gene Dmel\Slip1

General Information
SymbolDmel\Slip1SpeciesD. melanogaster
NameSlip1Annotation symbolCG1783
Feature typeprotein_coding_geneFlyBase IDFBgn0024728
Created / Updated2003-12-02/2003-12-02
Genomic Location
Chromosome (arm)4Recombination map
Cytogenetic map102C2-102C2Sequence location4:684,214..690,510 [+]
Map ( GBrowse ) detailed view
hide Summary Information
Automatically generated summary

See sections below for more information
This gene is referred to in FlyBase by the symbol Slip1 (CG1783, FBgn0024728). It has the cytological map location 102C2. Its sequence location is 4:684214..690510. Its molecular function is described as: potassium channel regulator activity; protein binding. The biological processes in which it is involved are not known. 2 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide.

hide Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
102C2-102C2  
Limits computationally determined from genome sequence between P{SUPor-P}AsatorKG05051&P{SUPor-P}KG01424 and PBac{3HPy+}C024  
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
102C-102D
(determined by in situ hybridisation)  
(Xia et al., 1998)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Molecular Map Data
Gene Order (in direction of increasing cytology)
References
Gene Order (overall orientation not stated)
References
hide Gene Model & Products
Please see the GBrowse view of Dmel\Slip1 for information on other features
detailed view FBtr0100165 FBtr0089090 FBpp0088159 FBti0024731 FBti0075255
Comments on Gene Model
hide Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Associated CDS (aa)
Slip1-RA
FBtr0089090
 NM_143676
  2851
  767
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
hide Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kD)
Length (aa)
Theoretical pI
RefSeq ID
GenBank protein
Slip1-PA  
FBpp0088159  
85.8  
767  
5.54  
  NP_651933
  AAF59321
Additional Polypeptide Data & Comments
Reported size (kD)
Comments
External Data
Linkouts
Crossreferences
InterPro domains - A database of protein families, domains, and functional sites
•
PDZ/DHR/GLGF (IPR001478)
hide Sequences Consistent with the Gene Model
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
AA263379
 
AA264733
 
AA391529
 
AA438679
 
AA439621
 
AA440860
 
AA567840
 
AA698798
 
AE003843
AAF59321
 
AF433691
AAM17954
 
AF433692
AAM17955
 
AI135439
 
AW942149
 
AY122157
AAM52669
 
BF492057
 
BG637690
 
BI164611
 
BI212576
 
BI229048
 
BI229058
 
BI229089
 
BI232870
 
BI235344
 
BI361973
 
BI364894
 
BI366414
 
BI369120
 
BI373211
 
BI373227
 
BI373969
 
CA807828
 
CO184909
 
CO186006
 
CO186234
 
CO192828
 
CO266015
 
CO278215
 
CO281513
 
CO283891
 
CO285168
 
CO293361
 
CO304857
 
CO305873
 
CO313739
 
CO314325
 
CO316454
 
CO325590
 
CO328010
 
CO328363
 
CO329489
 
CO330133
 
CO330512
 
CO339510
 
CO340442
 
EC063833
 
EC065204
 
EC066503
 
EC067360
 
EC074344
 
EC074915
 
EC088654
 
EC204962
 
EC228922
 
EC233476
 
EC233933
 
EC240658
 
EC244446
 
EC245295
 
EC247143
 
EC249307
 
EC249431
 
EC252752
 
EC254319
 
EC257753
 
EC258172
 
EC260290
 
ES695500
 
ES695507
 
ES695574
 
HL05713
 
 
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL
    Maps to
    Does NOT map to
    Identified with
    (BDGP Project Members, 2000-)
    hide Mapped Features & Mutations
    Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here
    Type
    Symbol & Location
    Additional Notes
    References
    hide External Data
    Linkouts
    DEDB - Drosophila exon database: splicing graphs
    •
    Crossreferences
    hide Expression Data
    FlyBase-Curated Data
    Transcript and
    Protein data     		Please see the FlyBase Gene Expression Report for details of gene expression from the literature.
    hide Summary of Transcript Expression
    Stage
    Tissue/Position
    Reference
    Marker for
      Subcellular Localization
      CV Term
      hide Summary of Polypeptide Expression
      Stage
      Tissue/Position
      Reference
      Marker for
        Subcellular Localization
        CV Term
        hide External Data & Images
        Linkouts
        FLIGHT - Cell culture data for RNAi and other high-throughput technologies
        •
        hide Alleles & Phenotypes
        hide Summary of Allele Phenotypes
        Phenotype manifest in
        Allele
        hide Classical Alleles ( 1 )
        For All Classical Alleles Show

        Allele of Slip1ClassMutagenStocksKnown lesion
        Slip1MB00262
          		1 --
          hide Alleles Carried on Transgenic Constructs ( 1 )
          For All Alleles Carried on Transgenic Constructs Show

          Allele of Slip1ClassMutagenStocksKnown lesion
          Slip1GD94752 Yes
          hide Aneuploid Aberrations
          hide Transgenic Constructs & Insertions
          Transgenic Constructs
          Type of construct
          Name
          Expression data
          UAS construct
          P{GD9475}
          NA
          Insertions
          Type of insertions
          Name
          Expression data
          insertion of enhancer trap binary system
          Mi{ET1}Slip1MB00262
          No
          hide Related Comments
          Please look at the allele reports for the complete phenotype data
          hide Gene Ontology: Function, Process & Cellular Component ( 4 )
          hide Molecular Function
          CV term
          Evidence
          References
          potassium channel regulator activity
          inferred from direct assay
          (Xia et al., 1998)
          protein binding
          inferred from physical interaction with FLYBASE:slo; FB:FBgn0003429
          (Xia et al., 1998)
          hide Biological Process
          CV term
          Evidence
          References
          biological_process
          no biological data available
          (FlyBase Curators, 2002-)
          hide Cellular Component
          CV term
          Evidence
          References
          cellular_component
          no biological data available
          (FlyBase Curators, 2002-)
          hide Sequence Ontology: Class of Gene
          protein_coding_gene
           
          nuclear_gene
           
          hide Interactions & Pathways
          hide Summary of Genetic Interactions
          Interacts with
          Please look at the allele data for full details of the genetic interactions
          Slip1 allele
          Gene
          References
          hide External Data
          Linkouts
          BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions
          •
          hide Orthologs
          Genome-wide drosophilid orthologs
          Curated drosophilid orthologs
           
          Linkouts
          InParanoid orthologs - Eukaryotic orthologs
          •
          hide Functional Complementation between Species
          hide Inter-Species Misexpression Data
          Produces phenotype in
          Produces NO phenotype in
          hide Stocks & Reagents
          hide Stocks Listed in FlyBase ( 3 )
          VDRC
          v33006
          w1118; P{GD9475}v33006
          v33007
          w1118; P{GD9475}v33007
          Bloomington
          22747
          y1; Mi{ET1}Slip1MB00262
          hide Genomic Clones ( 3 )
          hide cDNA Clones ( 51 )
          Please Note
          This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
          cDNA Clones, Fully Sequenced
          BDGP DGC clones
          Other clones
          cDNA Clones, End Sequenced (ESTs)
          BDGP DGC clones
          Other clones
          hide RNAi & Array Information
          Affy Oligo
          Linkouts
          DRSC - RNAi screening (Harvard): high-throughput cell culture data and design
          •
          hide Antibody Information
          hide Other Information
          hide Discoverer
          hide Etymology
          hide Identification
          hide Position Effect Variegation Data
          hide Relationship to Other Genes
          Source for database identity of
          Source for database merge of
          Source for merge of: Slip1 CG1783 Source for merge of Slip1 CG1783 was sequence comparison (date:040521).
          (FlyBase, 1996-)
          Additional comments
          hide Comments About Role
          hide Comments About Molecular Function
          hide Other Comments
          dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
          (Kiger et al., 2003)
          Identification: slo-interacting protein using yeast two-hybrid interaction system with an embryonic cDNA library.
          (Xia et al., 1998)
          hide External Crossreferences & Linkouts
          Sequence Crossreferences
          RefSeq (Transcripts)
          •
          RefSeq (Proteins)
          •
          DDBJ / EMBL / GenBank
          •
          UniProtKB/Swiss-Prot
          •
          Other Crossreferences
          InterPro domains - A database of protein families, domains, and functional sites
          •
          PDZ/DHR/GLGF (IPR001478)
          Linkouts
          BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions
          •
          DEDB - Drosophila exon database: splicing graphs
          •
          DRSC - RNAi screening (Harvard): high-throughput cell culture data and design
          •
          FLIGHT - Cell culture data for RNAi and other high-throughput technologies
          •
          FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans
          •
          InParanoid orthologs - Eukaryotic orthologs
          •
          hide Synonyms & Secondary IDs ( 3 )
          Reported As
          Symbol Synonym
          CG1783
          (Sousa-Neves et al., 2005, Giot et al., 2003, )
          dSLIP1
          (Xia et al., 1998)
          Slip1
           
          Name Synonym
          Slip1
           
          Secondary FlyBase IDs
          • FBgn0039919
          hide References ( 12 )
          Research paper
          Sousa-Neves et al., 2005, Genetics 170(1): 127--138
          High-resolution mapping of the Drosophila fourth chromosome using site-directed terminal deficiencies. [FBrf0187662]
          Wang et al., 2002, Science 295(5552): 134--137
          Nucleotide variation along the Drosophila melanogaster fourth chromosome. [FBrf0141759]
          Xia et al., 1998, J. Neurosci. 18(7): 2360--2369
          dSLo interacting protein 1, a novel protein that interacts with large-conductance calcium-activated potassium channels. [FBrf0102040]
          Supplementary material
          Giot et al., 2003, Science 302(5651):
          Tables S1 to S7. [FBrf0166452]
          Kiger et al., 2003, J. Biol. 2(4):
          Additional data file 1: The gene identity and primer sequences for dsRNAs used in the RNAi screens. [FBrf0174231]
          Personal communication to FlyBase
          Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center
          RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327]
          Bellen, 2006.11.6, Batch702.xml
          Batch702.xml [FBrf0191798]
          FlyBase analysis
          FlyBase Curators, 2002-, Use of the ND evidence code for Gene Ontology (GO) terms in FlyBase.
          Use of the ND evidence code for Gene Ontology (GO) terms in FlyBase. [FBrf0159398]
          FlyBase, 1996-, FlyBase inference based on genome sequence analysis.
          FlyBase inference based on genome sequence analysis. [FBrf0104946]
          FlyBase, 1992-, FlyBase curation
          FlyBase curation. [FBrf0105495]
          Computer file
          BDGP Project Members, 2000-, Berkeley Drosophila Genome Project.
          Berkeley Drosophila Genome Project. [FBrf0125078]
          Automatic genome annotation
          FamiliarityBreedsContempt, 1999.11, [Annotations performed at the Celera Jamboreee.]
          [Annotations performed at the Celera Jamboreee.] [FBrf0126705]