Gene Dmel\CG2196

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General Information

Symbol

Dmel\CG2196

Species

D. melanogaster

Name

CG2196

Annotation symbol

CG2196

Feature type

protein_coding_gene

FlyBase ID

FBgn0039872

Created / Updated

2003-12-01/2003-12-01

Genomic Location

Chromosome (arm)

Recombination map

Cytogenetic map

100D2-100D2

Sequence location

3R:27,577,531..27,580,413 [-]

Map ( GBrowse )

Summary Information

Automatically generated summary

See sections below for more information

This gene is referred to in FlyBase by the symbol CG2196 (FBgn0039872). It has the cytological map location 100D2. Its sequence location is 3R:27577531..27580413. Its molecular function is described as sodium:iodide symporter activity. It is involved in the biological process transport. 2 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide.

Detailed Mapping Data

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

100D2-100D2

Limits computationally determined from genome sequence between P{EP}pygo^EP1076 and P{PZ}ttk⁰²⁶⁶⁷&P{lacW}ttk^j6C7

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

Left of (cM)

Right of (cM)

Notes

Molecular Map Data

Gene Order (in direction of increasing cytology)

References

Gene Order (overall orientation not stated)

References

Gene Model & Products

Please see the GBrowse view of Dmel\CG2196 for information on other features

Comments on Gene Model

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Associated CDS (aa)

CG2196-RA

FBtr0085862

NM_143632

2128

626

Additional Transcript Data & Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kD)

Length (aa)

Theoretical pI

RefSeq ID

GenBank protein

CG2196-PA

FBpp0085221

68.7

626

7.56

NP_651889

AAF57191

Additional Polypeptide Data & Comments

Reported size (kD)

Comments

External Data

Linkouts

PANTHER - Protein classification by function, families, and pathways

•

FBgn0039872

Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

Na+/solute symporter (IPR001734)

Sequences Consistent with the Gene Model

DDBJ /
EMBL /
GenBank

DNA sequence

Protein sequence

Name

Maps to

Does NOT map to

Identified with

GH19680

(BDGP Project Members, 2000-)

Mapped Features & Mutations

Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here

Type

Symbol & Location

Additional Notes

References

External Data

Linkouts

DEDB - Drosophila exon database: splicing graphs

•

11487

Crossreferences

Expression Data

FlyBase-Curated Data

Transcript and
Protein data

Please see the FlyBase Gene Expression Report for details of gene expression from the literature.

Summary of Transcript Expression

Stage

Tissue/Position

Reference

Marker for

Subcellular Localization

CV Term

Summary of Polypeptide Expression

Stage

Tissue/Position

Reference

Marker for

Subcellular Localization

CV Term

Microarray Data

Developmental timecourse, Costello et al., 2008 (Original data from Arbeitman et al., 2002)

Untitled Document detailed view

AI388702

External Data & Images

Linkouts

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0039872

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

•

FBgn0039872

GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies

•

FBgn0039872

Alleles & Phenotypes

Summary of Allele Phenotypes

Phenotype manifest in

Allele

Classical Alleles ( 0 )

For All Classical Alleles Show

Allele of CG2196	Class	Mutagen	Stocks	Known lesion

Alleles Carried on Transgenic Constructs ( 2 )

For All Alleles Carried on Transgenic Constructs Show

Allele of CG2196	Class	Mutagen	Stocks	Known lesion
CG2196^GD12732		in vitro construct \| RNAi in vitro construct \| regulatory fusion	2	Yes
CG2196^GD574		in vitro construct \| RNAi in vitro construct \| regulatory fusion	0	Yes

Aneuploid Aberrations

Useful deficiency

Df(3R)R113

Useful duplication

Dp(3;3)516

Disrupted in

Df(3R)Exel6220

(Ryder, 2004.4.26)

Transgenic Constructs & Insertions

Transgenic Constructs

Type of construct

Name

Expression data

UAS construct

P{GD12732}

P{GD574}

Insertions

Type of insertions

Name

Expression data

Related Comments

Please look at the allele reports for the complete phenotype data

Gene Ontology: Function, Process & Cellular Component ( 3 )

Molecular Function

CV term

Evidence

References

sodium:iodide symporter activity

inferred from sequence or structural similarity with EMBL:D87920; protein_id:BAA24835

(FlyBase, 1992-)

Biological Process

CV term

Evidence

References

transport

inferred from electronic annotation with InterPro:IPR001734

(FlyBase Curators et al., 2004-)

Cellular Component

CV term

Evidence

References

membrane

inferred from electronic annotation with InterPro:IPR001734

(FlyBase Curators et al., 2004-)

Sequence Ontology: Class of Gene

protein_coding_gene

nuclear_gene

Interactions & Pathways

Summary of Genetic Interactions

Interacts with

Please look at the allele data for full details of the genetic interactions

CG2196 allele

Gene

References

External Data

Linkouts

BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions

•

68583

Orthologs

Genome-wide drosophilid orthologs

Dere\GG11856

Dper\GL23436

Dsim\GD16315

Curated drosophilid orthologs

Dpse\GA15294

Linkouts

InParanoid orthologs - Eukaryotic orthologs

•

Q7XBS0
Oryza sativa (Gramene)
Q9FRN4
Oryza sativa (Gramene)
AT5G45380.1
Arabidopsis thaliana (Arabidopsis)

Functional Complementation between Species

Inter-Species Misexpression Data

Produces phenotype in

Produces NO phenotype in

Stocks & Reagents

Stocks Listed in FlyBase ( 2 )

VDRC

v28349

w¹¹¹⁸; P{GD12732}v28349/TM3

v28350

w¹¹¹⁸; P{GD12732}v28350/TM3

Genomic Clones ( 1 )

BACR48C22

cDNA Clones ( 2 )

Please Note

This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA Clones, Fully Sequenced

BDGP DGC clones

GH19680

Other clones

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

LP15253

Other clones

RNAi & Array Information

Affy Oligo

Linkouts

DRSC - RNAi screening (Harvard): high-throughput cell culture data and design

•

FBgn0039872

GenomeRNAi - RNAi phenotypes (Heidelberg): high-throughput cell culture data

•

FBgn0039872

Antibody Information

Other Information

Discoverer

Etymology

Identification

Position Effect Variegation Data

Relationship to Other Genes

Source for database identity of

Source for database merge of

Additional comments

One of the introns of CG2196 has the sequence and structural characteristics of a "mirtron"- mirtrons are encoded as an intron of another gene which accumulate as a lariats after splicing and require debranching enzyme for conversion into a functional miRNA. The mirtron encoded by the CG2196 intron is mir-1014.

(Ruby et al., 2007)

Comments About Role

Comments About Molecular Function

Other Comments

External Crossreferences & Linkouts

Sequence Crossreferences

RefSeq (Transcripts)

•

NM_143632

RefSeq (Proteins)

•

NP_651889

DDBJ / EMBL / GenBank

•

UniProtKB/TrEMBL

•

Other Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

Na+/solute symporter (IPR001734)

Linkouts

BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions

•

68583

DEDB - Drosophila exon database: splicing graphs

•

11487

DRSC - RNAi screening (Harvard): high-throughput cell culture data and design

•

FBgn0039872

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0039872

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

•

FBgn0039872

FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans

•

FBgn0039872

GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies

•

FBgn0039872

GenomeRNAi - RNAi phenotypes (Heidelberg): high-throughput cell culture data

•

FBgn0039872

InParanoid orthologs - Eukaryotic orthologs

•

Q7XBS0
Oryza sativa (Gramene)
Q9FRN4
Oryza sativa (Gramene)
AT5G45380.1
Arabidopsis thaliana (Arabidopsis)

PANTHER - Protein classification by function, families, and pathways

•

FBgn0039872

University of Chicago Dev. Expression

•

FBgn0039872

Synonyms & Secondary IDs ( 1 )

Reported As

Symbol Synonym

CG2196

(Ruby et al., 2007)

Name Synonym

CG2196

Secondary FlyBase IDs

References ( 9 )

Supplementary material

Dietzl et al., 2007, Nature 448(7150):: Supplementary Table 1. [FBrf0202579]
Ruby et al., 2007, Nature 448(7149):: Supplementary information. [FBrf0202573]

Personal communication to FlyBase

Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center: RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327]
FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms.: Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215]
Ryder, 2004.4.26, Exelixis CG deletion data.: Exelixis CG deletion data. [FBrf0184335]

FlyBase analysis

FlyBase, 1992-, FlyBase curation: FlyBase curation. [FBrf0105495]

Computer file

BDGP Project Members, 2000-, Berkeley Drosophila Genome Project.: Berkeley Drosophila Genome Project. [FBrf0125078]

Automatic genome annotation

FamiliarityBreedsContempt, 1999.11, [Annotations performed at the Celera Jamboreee.]: [Annotations performed at the Celera Jamboreee.] [FBrf0126705]

Curated genome annotation

Kodira, 1999.11, [Annotations performed at the Celera Jamboreee.]: [Annotations performed at the Celera Jamboreee.] [FBrf0126678]