Gene Dmel\CG2246

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General Information

Symbol

Dmel\CG2246

Species

D. melanogaster

Name

CG2246

Annotation symbol

CG2246

Feature type

protein_coding_gene

FlyBase ID

FBgn0039790

Created / Updated

2003-12-01/2003-12-01

Genomic Location

Chromosome (arm)

Recombination map

Cytogenetic map

99F10-100A1

Sequence location

3R:26,418,734..26,427,211 [-]

Map ( GBrowse )

Summary Information

Automatically generated summary

See sections below for more information

This gene is referred to in FlyBase by the symbol CG2246 (FBgn0039790). It has the cytological map location 99F10-100A1. Its sequence location is 3R:26418734..26427211. Its molecular function is described as: ribose phosphate diphosphokinase activity; magnesium ion binding. It is involved in the biological processes: nucleotide biosynthetic process; nucleoside metabolic process. 9 alleles are reported. No phenotypic data is available. It has 6 annotated transcripts and 6 annotated polypeptides.

Detailed Mapping Data

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

99F10-100A1

Limits computationally determined from genome sequence between P{PZ}ncd⁰⁵⁸⁸⁴ and P{lacW}l(3)s2500^s2500

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

Left of (cM)

Right of (cM)

Notes

Molecular Map Data

Gene Order (in direction of increasing cytology)

References

Gene Order (overall orientation not stated)

References

Overall orientation not stated: CG2246+ anon-AE003774.1- CG2246+

(Robertson, 2001.7.7)

Gene Model & Products

Please see the GBrowse view of Dmel\CG2246 for information on other features

Comments on Gene Model

EST data support existence of multiple transcripts

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Associated CDS (aa)

CG2246-RA

FBtr0085673

NM_170510

1740

406

CG2246-RB

FBtr0085675

NM_170507

1542

387

CG2246-RC

FBtr0085674

NM_170511

1524

386

CG2246-RD

FBtr0085676

NM_170508

1575

367

CG2246-RE

FBtr0085678

NM_143556

1585

386

CG2246-RF

FBtr0085677

NM_170509

1768

367

Additional Transcript Data & Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kD)

Length (aa)

Theoretical pI

RefSeq ID

GenBank protein

CG2246-PA

FBpp0085035

44.8

406

8.32

NP_733389

AAF57070

CG2246-PB

FBpp0085037

42.9

387

8.55

NP_733386

AAN14244

CG2246-PC

FBpp0085036

42.5

386

7.29

NP_733390

AAN14247

CG2246-PD

FBpp0085038

40.5

367

7.57

NP_733387

AAN14245

CG2246-PE

FBpp0085040

42.5

386

7.29

NP_651813

AAN14248

CG2246-PF

FBpp0085039

40.5

367

7.57

NP_733388

AAN14246

Additional Polypeptide Data & Comments

Reported size (kD)

Comments

External Data

Linkouts

PANTHER - Protein classification by function, families, and pathways

•

FBgn0039790

Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

Phosphoribosyltransferase (IPR000836)

Phosphoribosyl pyrophosphokinase (IPR005946)

Sequences Consistent with the Gene Model

DDBJ /
EMBL /
GenBank

DNA sequence

Protein sequence

Name

Maps to

Does NOT map to

Identified with

GH05377

(BDGP Project Members, 2000-)

Mapped Features & Mutations

Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here

Type

Symbol & Location

Additional Notes

References

External Data

Linkouts

DEDB - Drosophila exon database: splicing graphs

•

11381

Crossreferences

Expression Data

FlyBase-Curated Data

Transcript and
Protein data

Please see the FlyBase Gene Expression Report for details of gene expression from the literature.

Summary of Transcript Expression

Stage

Tissue/Position

Reference

Marker for

Subcellular Localization

CV Term

Summary of Polypeptide Expression

Stage

Tissue/Position

Reference

Marker for

Subcellular Localization

CV Term

Microarray Data

Developmental timecourse, Costello et al., 2008 (Original data from Arbeitman et al., 2002)

Untitled Document detailed view

AI519319
AI403605
AI107608
AI108281

External Data & Images

Linkouts

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0039790

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

•

FBgn0039790

GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies

•

FBgn0039790

FlyExpress - Embryonic expression images (BDGP data)

•

Show all FlyExpress processed images for CG2246

Alleles & Phenotypes

Summary of Allele Phenotypes

Lethality

Allele

viable

Sterility

Allele

fertile

Phenotype manifest in

Allele

Classical Alleles ( 7 )

For All Classical Alleles Show

Allele of CG2246	Mutagen	Stocks	Known lesion
CG2246^DG25703	P-element activity	1	--
CG2246^EY03143	P-element activity	1	--
CG2246^PL00407	P-element activity	1	--
CG2246^c03595	piggyBac transposase	0	--
CG2246^c05287	piggyBac transposase	1	--
CG2246^c06743	piggyBac transposase	0	--
CG2246^f04914	piggyBac transposase	1	--

Alleles Carried on Transgenic Constructs ( 2 )

For All Alleles Carried on Transgenic Constructs Show

Allele of CG2246	Class	Mutagen	Stocks	Known lesion
CG2246^GD16501		in vitro construct \| RNAi in vitro construct \| regulatory fusion	2	Yes
CG2246^GD8643		in vitro construct \| RNAi in vitro construct \| regulatory fusion	2	Yes

Aneuploid Aberrations

Useful deficiency

Df(3R)tll-g

Useful duplication

Dp(3;3)516

Disrupted in

Df(3R)Exel7378

(Ryder, 2004.4.26)

Transgenic Constructs & Insertions

Transgenic Constructs

Type of construct

Name

Expression data

UAS construct

P{GD16501}

P{GD8643}

Insertions

Type of insertions

Name

Expression data

miscellaneous insertions

PBac{PB}CG2246^c03595

PBac{PB}CG2246^c05287

PBac{PB}CG2246^c06743

PBac{WH}CG2246^f04914

P{wHy}CG2246^DG25703

insertion of enhancer trap binary system

PBac{GAL4D,EYFP}CG2246^PL00407

insertion of mobile activating element

P{EPgy2}CG2246^EY03143

Related Comments

Please look at the allele reports for the complete phenotype data

Gene Ontology: Function, Process & Cellular Component ( 4 )

Molecular Function

CV term

Evidence

References

magnesium ion binding

inferred from electronic annotation with InterPro:IPR005946

(FlyBase Curators et al., 2004-)

ribose phosphate diphosphokinase activity

inferred from sequence or structural similarity with EMBL:AB007851; protein_id:BAA25435.1

(FlyBase, 1992-)

Biological Process

CV term

Evidence

References

nucleoside metabolic process

inferred from electronic annotation with InterPro:IPR000836

(FlyBase Curators et al., 2004-)

nucleotide biosynthetic process

inferred from electronic annotation with InterPro:IPR005946

(FlyBase Curators et al., 2004-)

Cellular Component

CV term

Evidence

References

Sequence Ontology: Class of Gene

protein_coding_gene

nuclear_gene

Interactions & Pathways

Summary of Genetic Interactions

Interacts with

Please look at the allele data for full details of the genetic interactions

CG2246 allele

Gene

References

External Data

Linkouts

BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions

•

68488

Orthologs

Genome-wide drosophilid orthologs

Dana\GF23320

Dere\GG11922

Dgri\GH14115

Dmoj\GI10642

Dper\GL14002

Dpse\GA26930

Dsec\GM12142

Dsim\GD16936

Dvir\GJ22998

Dwil\GK13119

Dyak\GE23373

Curated drosophilid orthologs

Dpse\GA15319

Linkouts

InParanoid orthologs - Eukaryotic orthologs

•

ENSANGP00000018618
Anopheles gambiae (Ensembl)
ENSBTAP00000019786
Bos taurus (Ensembl)
ENSCAFP00000026958
Canis familiaris (Ensembl)
ENSCINP00000004419
Ciona intestinalis (Ensembl)
NEWSINFRUP00000147889
Takifugu rubripes (Ensembl)
ENSGALP00000008105
Gallus gallus (Ensembl)
ENSP00000268835
Homo sapiens (Ensembl)
ENSMMUP00000004718
Macaca mulatta (Ensembl)
ENSMODP00000001007
Monodelphis domestica (Ensembl)
ENSPTRP00000015118
Pan troglodytes (Ensembl)
ENSRNOP00000048818
Rattus norvegicus (Ensembl)
GSTENP00021842001
Tetraodon nigroviridis (Ensembl)
ENSXETP00000042287
Xenopus tropicalis (Ensembl)
WBGene00037109
Caenorhabditis briggsae (Wormbase)
WBGene00012258
Caenorhabditis elegans (Wormbase)
ZDB-CDNA-040425-3024
Danio rerio (Zfin)
ZDB-CDNA-040425-3835
Danio rerio (Zfin)
ZDB-GENE-040426-2077
Danio rerio (Zfin)
MGI:2384838
Mus musculus (Informatics)

Functional Complementation between Species

Inter-Species Misexpression Data

Produces phenotype in

Produces NO phenotype in

Stocks & Reagents

Stocks Listed in FlyBase ( 9 )

Harvard

PBac{PB}CG2246^c05287

PBac{WH}CG2246^f04914

VDRC

v24985

w¹¹¹⁸; P{GD8643}v24985

v24987

w¹¹¹⁸; P{GD8643}v24987

v48877

w¹¹¹⁸; P{GD16501}v48877

v48878

w¹¹¹⁸; P{GD16501}v48878

Bloomington

16555

y¹ w^67c23; P{EPgy2}CG2246^EY03143

19485

w^*; P{FRT(w^hs)}2A P{neoFRT}82B PBac{GAL4D,EYFP}CG2246^PL00407

21290

y¹ w^67c23; P{wHy}CG2246^DG25703/TM3, Sb¹ Ser¹

Genomic Clones ( 2 )

cDNA Clones ( 34 )

Please Note

This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA Clones, Fully Sequenced

BDGP DGC clones