A Database of Drosophila Genes & Genomes

FB2008_07, released August 8, 2008
 

Gene Dmel\capa

General Information
SymbolDmel\capaSpeciesD. melanogaster
NamecapabilityAnnotation symbolCG15520
Feature typeprotein_coding_geneFlyBase IDFBgn0039722
Created / Updated2003-12-01/2003-12-01
Genomic Location
Chromosome (arm)3RRecombination map
Cytogenetic map99C6-99C6Sequence location3R:25,738,707..25,740,050 [-]
Map ( GBrowse ) detailed view
hide Summary Information
Automatically generated summary

See sections below for more information
The gene capability is referred to in FlyBase by the symbol capa (CG15520, FBgn0039722). It has the cytological map location 99C6. Its sequence location is 3R:25738707..25740050. Its molecular function is described as: myostimulatory hormone activity; neuropeptide hormone activity; diuretic hormone activity; receptor binding. It is involved in the biological processes: neuropeptide signaling pathway; regulation of heart contraction; epithelial fluid transport; cation transport. One allele is reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide.
hide Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
99C6-99C6  
Limits computationally determined from genome sequence between P{PZ}ncd05884 and P{lacW}l(3)s2500s2500  
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
99D-99D
 
(Davies, 1999.11.10)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Molecular Map Data
Gene Order (in direction of increasing cytology)
References
In direction of increasing cytology: CG31036+ capa- trp-
(Kean et al., 2002)
Gene Order (overall orientation not stated)
References
hide Gene Model & Products
Please see the GBrowse view of Dmel\capa for information on other features
detailed view FBtr0085501 FBtr0114571 FBtr0085514 FBtr0085513 FBpp0113063 FBpp0084867 FBpp0084880 FBpp0084879
Comments on Gene Model
hide Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Associated CDS (aa)
capa-RA
FBtr0085514
 NM_079828
  683
  151
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
hide Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kD)
Length (aa)
Theoretical pI
RefSeq ID
GenBank protein
capa-PA  
FBpp0084880  
16.5  
151  
9.51  
  NP_524552
  AAF56969
Additional Polypeptide Data & Comments
Reported size (kD)
Comments
External Data
Linkouts
PANTHER - Protein classification by function, families, and pathways
•
Crossreferences
InterPro domains - A database of protein families, domains, and functional sites
•
Pyrokinin, conserved site (IPR001484)
hide Sequences Consistent with the Gene Model
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
AE003771
AAF56969
 
AF203878
AAF62876
 
AI389756
 
AI517299
 
AJ291724
CAC17603
 
AW941082
 
AY069234
AAL39379
 
CO340396
 
EC224331
 
EC258164
 
 
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL
    Maps to
    Does NOT map to
    Identified with
    (BDGP Project Members, 2000-, Hewes and Taghert, 2001)
    (Park, 2001.5.22)
    hide Mapped Features & Mutations
    Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here
    Type
    Symbol & Location
    Additional Notes
    References
    hide External Data
    Linkouts
    DEDB - Drosophila exon database: splicing graphs
    •
    Crossreferences
    hide Expression Data
    FlyBase-Curated Data
    Transcript and
    Protein data     		Please see the FlyBase Gene Expression Report for details of gene expression from the literature.
    hide Summary of Transcript Expression
    Stage
    Tissue/Position
    Reference
    Marker for
      Subcellular Localization
      CV Term
      hide Summary of Polypeptide Expression
      Stage
      Tissue/Position
      Reference
      Marker for
        Subcellular Localization
        CV Term
        hide Microarray Data
        Developmental timecourse, Costello et al., 2008 (Original data from Arbeitman et al., 2002)
        Untitled Document detailed view FBtr0085501 FBtr0114571 FBtr0085514 FBtr0085513
        AI517299
        hide External Data & Images
        Linkouts
        FLIGHT - Cell culture data for RNAi and other high-throughput technologies
        •
        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
        •
        GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies
        •
        hide Alleles & Phenotypes
        hide Summary of Allele Phenotypes
        Phenotype manifest in
        Allele
        hide Classical Alleles ( 0 )
        For All Classical Alleles Show

        Allele of capaClassMutagenStocksKnown lesion
        hide Alleles Carried on Transgenic Constructs ( 1 )
        For All Alleles Carried on Transgenic Constructs Show

        Allele of capaClassMutagenStocksKnown lesion
        capaGD46711 Yes
        hide Aneuploid Aberrations
        Useful deficiency
         
        Useful duplication
         
        Disrupted in
        (Ryder, 2004.4.26)
        hide Transgenic Constructs & Insertions
        Transgenic Constructs
        Type of construct
        Name
        Expression data
        UAS construct
        P{GD4671}
        NA
        Insertions
        Type of insertions
        Name
        Expression data
        hide Related Comments
        Please look at the allele reports for the complete phenotype data
        hide Gene Ontology: Function, Process & Cellular Component ( 9 )
        hide Molecular Function
        CV term
        Evidence
        References
        diuretic hormone activity
        non-traceable author statement
        (van den Broeck, 2000.11.27)
        traceable author statement
        (Baggerman et al., 2002)
        myostimulatory hormone activity
        non-traceable author statement
        (Davies, 1999.11.10)
        non-traceable author statement
        (van den Broeck, 2000.11.27)
        neuropeptide hormone activity
        non-traceable author statement
        (Davies et al., 1997)
        non-traceable author statement
        (Dow, 2000.9.7)
        inferred from sequence or structural similarity
        (vanden Broeck, 2001)
        non-traceable author statement
        (Hewes and Taghert, 2001)
        inferred from electronic annotation with InterPro:IPR001484
        (FlyBase Curators et al., 2004-)
        receptor binding
        inferred from sequence or structural similarity
        (Park et al., 2002)
        hide Biological Process
        CV term
        Evidence
        References
        cation transport
        traceable author statement
        (O'Donnell et al., 2003)
        epithelial fluid transport
        inferred from direct assay
        (Kean et al., 2002)
        neuropeptide signaling pathway
        non-traceable author statement
        (Davies, 1999.11.10)
        inferred from sequence or structural similarity
        (vanden Broeck, 2001)
        traceable author statement
        (Baggerman et al., 2002)
        inferred from electronic annotation with InterPro:IPR001484
        (FlyBase Curators et al., 2004-)
        regulation of heart contraction
        non-traceable author statement
        (Davies et al., 1997)
        hide Cellular Component
        CV term
        Evidence
        References
        extracellular region
        non-traceable author statement
        (Davies, 1999.11.10)
        hide Sequence Ontology: Class of Gene
        protein_coding_gene
         
        nuclear_gene
         
        hide Interactions & Pathways
        hide Summary of Genetic Interactions
        Interacts with
        Please look at the allele data for full details of the genetic interactions
        capa allele
        Gene
        References
        hide External Data
        Linkouts
        BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions
        •
        hide Orthologs
        Genome-wide drosophilid orthologs
        Curated drosophilid orthologs
         
        Linkouts
        InParanoid orthologs - Eukaryotic orthologs
        •
        hide Functional Complementation between Species
        hide Inter-Species Misexpression Data
        Produces phenotype in
        Produces NO phenotype in
        hide Stocks & Reagents
        hide Stocks Listed in FlyBase ( 1 )
        VDRC
        v41124
        w1118; P{GD4671}v41124
        hide Genomic Clones ( 2 )
        hide cDNA Clones ( 3 )
        Please Note
        This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
        cDNA Clones, Fully Sequenced
        BDGP DGC clones
        Other clones
        cDNA Clones, End Sequenced (ESTs)
        BDGP DGC clones
        Other clones
        hide RNAi & Array Information
        Affy Oligo
        Linkouts
        DRSC - RNAi screening (Harvard): high-throughput cell culture data and design
        •
        GenomeRNAi - RNAi phenotypes (Heidelberg): high-throughput cell culture data
        •
        hide Antibody Information
        hide Other Information
        hide Discoverer
        hide Etymology
        Etymology: gene is named "capability" because it clearly has the ability to encode two neuropeptides of the CAP2b family.
        (Kean et al., 2002)
        hide Identification
        hide Position Effect Variegation Data
        hide Relationship to Other Genes
        Source for database identity of
        Source for identity of: capa CG15520
        (Dow, 2000.8.16)
        Source for database merge of
        Source for merge of: capa Cap-2b
        (Dow, 2003.2.21)
        Additional comments
        hide Comments About Role
        A peptide with similar properties to CAP2b of M.sexta has been isolated from adult Drosophila. It stimulates fluid secretion by Malpighian tubules.
        (Davies et al., 1995)
        hide Comments About Molecular Function
        Identified as a gene with significant level of mRNA cycling as assessed by expression analysis using high density oligonucleotide arrays with probe generated from adult heads harvested over six time points over the course of a day. Shows alteration in expression in a Clk mutant background.
        (McDonald and Rosbash, 2001)
        The "capa-1" and "capa-2" peptides encoded by capa increase fluid secretion rates, stimulate nitric oxide production and elevate intracellular Ca2+ and cGMP in principal cells in the Malpighian tubule. The actions of capa-1" and "capa-2" are not synergistic.
        (Kean et al., 2002)
        hide Other Comments
        Transcription of Nos in Malpighian tubules is stimulated by cardioacceleratory peptide 2b (capa); this is dependent on the activation of a soluble guanylate cyclase.
        (Rosay et al., 1997)
        hide External Crossreferences & Linkouts
        Sequence Crossreferences
        RefSeq (Transcripts)
        •
        RefSeq (Proteins)
        •
        DDBJ / EMBL / GenBank
        •
        UniProtKB/Swiss-Prot
        •
        Other Crossreferences
        InterPro domains - A database of protein families, domains, and functional sites
        •
        Pyrokinin, conserved site (IPR001484)
        Linkouts
        BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions
        •
        DEDB - Drosophila exon database: splicing graphs
        •
        DRSC - RNAi screening (Harvard): high-throughput cell culture data and design
        •
        FLIGHT - Cell culture data for RNAi and other high-throughput technologies
        •
        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
        •
        FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans
        •
        GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies
        •
        GenomeRNAi - RNAi phenotypes (Heidelberg): high-throughput cell culture data
        •
        InParanoid orthologs - Eukaryotic orthologs
        •
        PANTHER - Protein classification by function, families, and pathways
        •
        University of Chicago Dev. Expression
        •
        hide Synonyms & Secondary IDs ( 37 )
        Reported As
        Symbol Synonym
        CAP2b
        (Dow, 2003.2.21, Dow et al., 2001, Dow and Davies, 1999)
        Cap-2b
        (Yang et al., 2000, Prokop, 1999, Davies et al., 1997, )
        CAP-2b
        (Prokop, 1999)
        CAP2B-1
        (Park et al., 2003)
        CAP2b-1
        (Park et al., 2002)
        CAP2B-2
        (Park et al., 2003)
        CAP2b-2
        (Park et al., 2002)
        CAP2b-3
        (Choi et al., 2003, Park et al., 2002)
        CAP2B-3
        (Park et al., 2003)
        CAP2B/pyrokinin
        (Hewes and Taghert, 2001)
        CAP2b
        (Macpherson et al., 2005, Davies, 2000, O'Donnell and Spring, 2000, Radford et al., 2002, Pollock et al., 2003, Blumenthal, 2001, Pollock et al., 2000, MacPherson et al., 2000, Broderick et al., 2000, Yang et al., 2000, Davies et al., 1997, Rosay et al., 1997, Davies et al., 1997)
        capa
        (Melcher and Pankratz, 2005)
        CAPA
        (Southall et al., 2006)
        capa-1
        (MacPherson et al., 2004, O'Donnell et al., 2003, Rosenkilde et al., 2003, Egerod et al., 2003, Egerod et al., 2003, Cazzamali et al., 2003, Iversen et al., 2002, Iversen et al., 2002, Kean et al., 2002)
        Capa-1
        (Cazzamali et al., 2005, Terhzaz et al., 2006)
        capa-2
        (O'Donnell et al., 2003, Rosenkilde et al., 2003, Egerod et al., 2003, Egerod et al., 2003, Cazzamali et al., 2003, Iversen et al., 2002, Iversen et al., 2002, Kean et al., 2002)
        Capa-2
        (Cazzamali et al., 2005)
        capa-3
        (Rosenkilde et al., 2003, Egerod et al., 2003, Egerod et al., 2003, Iversen et al., 2002, Kean et al., 2002, Cazzamali et al., 2005)
        CG15520
        (Wegener et al., 2002, Choi et al., 2001, Hewes and Taghert, 2001, Park, 2001.5.22, Dow, 2000.9.7, Dow, 2000.8.16, )
        Drm-CAP-1
        (Baggerman et al., 2002, vanden Broeck, 2001)
        Drm-CAP-2
        (Baggerman et al., 2002, vanden Broeck, 2001)
        Drm-CAP2b/MT
        (vanden Broeck, 2001)
        Drm-MT
        (vanden Broeck, 2001)
        Drm-PK-1
        (Rosenkilde et al., 2003, Cazzamali et al., 2005)
        Drm-PVK-1
        (Wegener et al., 2002)
        Drm-PVK-2
        (Wegener et al., 2002)
        pyrokinin/PBAN-like
        (Choi et al., 2001)
        Name Synonym
        cap2b-like
        (Park et al., 2002)
        capability
        (Davies, 1999.11.10)
        Cardioacceleratory peptide-2b
         
        Drm-myotropin
        (Rosenkilde et al., 2003, Cazzamali et al., 2005)
        myotropin
        (Cazzamali et al., 2003)
        myotropin-CAP2b-like
        (van den Broeck, 2000.11.27)
        pyrokinin
        (Cazzamali et al., 2003)
        pyrokinin-1
        (Cazzamali et al., 2005)
        pyrokinin-like
        (Wegener et al., 2002)
        TGPSASSGLWFGPRLamide
        (Rosenkilde et al., 2003)
        Secondary FlyBase IDs
        • FBgn0016129
        hide References ( 51 )
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        hide Recent research papers ( 2 )
        Southall et al., 2006, Physiol. Genomics 26(1): 35--45
        Novel subcellular locations and functions for secretory pathway Ca2+/Mn2+-ATPases. [FBrf0194731]
        Terhzaz et al., 2006, J. Biol. Chem. 281(27): 18849--18858
        Differential gel electrophoresis and transgenic mitochondrial calcium reporters demonstrate spatiotemporal filtering in calcium control of mitochondria. [FBrf0192802]
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