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A Database of Drosophila Genes & Genomes

FB2008_07, released August 8, 2008

Gene Dmel\alph

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General Information

Symbol

Dmel\alph

Species

D. melanogaster

Name

alphabet

Annotation symbol

CG1906

Feature type

protein_coding_gene

FlyBase ID

FBgn0086361

Created / Updated

2007-06-14/2007-06-14

Genomic Location

Chromosome (arm)

3R

Recombination map

Cytogenetic map

99B4-99B5

Sequence location

3R:25,417,544..25,442,879 [+]

Map ( GBrowse )

detailed view

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Summary Information

Automatically generated summary

See sections below for more information

The gene alphabet is referred to in FlyBase by the symbol alph (CG1906, FBgn0086361). It has the cytological map location 99B4-99B5. Its sequence location is 3R:25417544..25442879. Its molecular function is described as: protein serine/threonine phosphatase activity; magnesium ion binding; manganese ion binding. It is involved in the biological processes: response to oxidative stress; compound eye morphogenesis; imaginal disc-derived wing morphogenesis; protein amino acid dephosphorylation; negative regulation of Ras protein signal transduction; positive regulation of R7 cell differentiation; negative regulation of MAP kinase activity. 9 alleles are reported. The phenotypes of these alleles are annotated with: eye; wing; wing vein; photoreceptor cell R7; cone cell; primary pigment cell; secondary pigment cell; tertiary pigment cell. It has 5 annotated transcripts and 5 annotated polypeptides.

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Detailed Mapping Data

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

99B4-99B5

Limits computationally determined from genome sequence between P{PZ}l(3)06743⁰⁶⁷⁴³ and P{PZ}ncd⁰⁵⁸⁸⁴

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

99A-99B

(Therrien et al., 2000)

Experimentally Determined Recombination Data

Location

Left of (cM)

Right of (cM)

Notes

Molecular Map Data

Gene Order (in direction of increasing cytology)

References

Gene Order (overall orientation not stated)

References

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Gene Model & Products

Please see the GBrowse view of Dmel\alph for information on other features

detailed view

Comments on Gene Model

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Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Associated CDS (aa)

FBtr0085442

1657

368

FBtr0085443

2231

371

FBtr0085446

1413

368

FBtr0085445

1489

368

FBtr0085444

1692

374

Additional Transcript Data & Comments

Reported size (kB)

Comments

External Data

Crossreferences

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Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kD)

Length (aa)

Theoretical pI

RefSeq ID

GenBank protein

alph-PA

FBpp0084808

41.0

368

4.95

NP_733295

AAF56905

alph-PB

FBpp0084809

41.4

371

4.77

NP_733298

AAN14179

alph-PC

FBpp0084812

41.0

368

4.95

NP_733296

AAN14177

alph-PD

FBpp0084811

41.0

368

4.95

NP_733297

AAN14178

alph-PE

FBpp0084810

41.6

374

4.88

NP_651701

AAN14176

Additional Polypeptide Data & Comments

Reported size (kD)

Comments

External Data

Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

Protein phosphatase 2C (IPR015655)

Protein serine/threonine phosphatase 2C, C-terminal (IPR012911)

Protein phosphatase 2C-related (IPR001932)

Protein phosphatase 2C, manganese/magnesium aspartate binding site (IPR000222)

Protein phosphatase 2C, N-terminal (IPR014045)

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Sequences Consistent with the Gene Model

DDBJ /
EMBL /
GenBank

DNA sequence

Protein sequence

Name

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Maps to

Does NOT map to

Identified with

(Oliver, 2001.8.16)

LD23542

(BDGP Project Members, 2000-)

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Mapped Features & Mutations

Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here

Type

Symbol & Location

Additional Notes

References

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External Data

Crossreferences

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Expression Data

FlyBase-Curated Data

Transcript and
Protein data

Please see the FlyBase Gene Expression Report for details of gene expression from the literature.

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Summary of Transcript Expression

Stage

Tissue/Position

Reference

Marker for

Subcellular Localization

CV Term

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Summary of Polypeptide Expression

Stage

Tissue/Position

Reference

Marker for

Subcellular Localization

CV Term

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External Data & Images

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Alleles & Phenotypes

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Summary of Allele Phenotypes

Lethality

Allele

semi-viable (with alph^XS-88)

alph^S-355

semi-viable (with alph^S-355)

semi-viable (with alph^S-331)

alph^S-355

lethal | recessive

Other Phenotypes

Allele

visible (with alph^XS-88)

alph^S-355

visible (with alph^S-355)

visible (with alph^S-331)

alph^S-355

Sterility

Allele

alph^c04528

Phenotype manifest in

Allele

eye (with alph^S-355)

wing (with alph^S-355)

wing vein (with alph^S-355)

photoreceptor cell R7 | supernumerary

alph^S-331

primary pigment cell

alph^S-331

secondary pigment cell | supernumerary

alph^S-331

tertiary pigment cell | supernumerary

alph^S-331

eye (with alph^XS-88)

alph^S-355

wing (with alph^XS-88)

alph^S-355

wing vein (with alph^XS-88)

alph^S-355

eye (with alph^S-331)

alph^S-355

wing (with alph^S-331)

alph^S-355

wing vein (with alph^S-331)

alph^S-355

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Classical Alleles ( 8 )

For All Classical Alleles Show

Allele of alph	Class	Mutagen	Stocks	Known lesion
alph^MB01683			0	--
alph^S-292			0	--
alph^S-331			0	Yes
alph^S-355			0	Yes
alph^XS-88			0	Yes
alph^c04528		piggyBac transposase	2	--
alph^f03783		piggyBac transposase	1	--
alph^f05750		piggyBac transposase	0	--

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Alleles Carried on Transgenic Constructs ( 1 )

For All Alleles Carried on Transgenic Constructs Show

Allele of alph	Class	Mutagen	Stocks	Known lesion
alph^GD8826		in vitro construct \| RNAi in vitro construct \| regulatory fusion	1	Yes

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Aneuploid Aberrations

Useful deficienc